Intracellular Innate Immunity of Antibodies
A special issue of Antibodies (ISSN 2073-4468).
Deadline for manuscript submissions: closed (30 June 2017) | Viewed by 17783
Interests: study of B-cell response to tumors and B-cell interactions with innate immunity in the tumor microenvironment; development and evaluation of affinity reagents for diagnostic and targeted-imaging of cancer and therapy for ovarian cancer
The immune system provides critical protection against pathogens, both through the adaptive immune system, which is highly specific and endowed of memory but slow to develop on first exposure, and the innate immune system, which can immediately sense any intracellular pathogens through the recognition of molecular patterns associated with pathogens (PAMPs) or damaged cells (DAMPs, danger signals, or alarmins) by germline-encoded pattern recognition receptors (PRRs). Cell single sensing can elicit multiple immune responses to efficiently reduce spreading infection. Adaptive immune responses are carried out by activated B and T cells, which produce antigen-specific antibodies or cytotoxic T cells, respectively. Antibodies that patrol the extracellular spaces bind to pathogens, which directly inactivate pathogen functions or prime them for destruction by complement (complement-dependent cytotoxicity, CDC) or phagocytosis (antibody-dependent cell-mediated cytotoxicity, ADCC). In addition to these mechanisms, antibodies also activate intracellular innate immunity when they are carried in the cell during pathogen entry. Once in the cell, pathogen-attached antibodies bind to a cytosolic antibody receptor (Tripartite motif-containing 21, TRIM21) that mediates antibody-dependent intracellular neutralization (ADIN). While ADIN has only been observed to act against adenovirus thus far, it is likely to also be effective against other pathogens. This Special Issue of Antibodies focuses on intracellular innate immunity of antibodies, with specific emphasis on different pathogenic mechanisms, potential therapeutic options and critical information that can be derived from the study of intracellular innate immunity.
Dr. Nathalie Scholler
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibodies is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
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