Antibody Repertoire Mining for Immune Profiling, Antibody Discovery and Vaccine Design
A special issue of Antibodies (ISSN 2073-4468).
Deadline for manuscript submissions: closed (28 February 2019) | Viewed by 20204
Interests: antibody discovery; immunoinformatics; protein/antibody engineering; computational biology
Special Issues, Collections and Topics in MDPI journals
Interests: next-generation sequencing of immune repertoires for biologics/vaccine discovery; infectious disease prevention, vaccine design, protein/antibody design and engineering; bioinformatics; immunology
Immunogenetic mechanisms underlying the complex processes of antibody V(D)J gene rearrangement, junctional modification, and somatic mutation, which appear to randomly create repertoires of vast diversity. However, detailed analyses of antibody repertories in different stages of ontogeny, development, immunological condition and responses have demonstrated that normal and immune repertoires can be constrained and shaped by natural selection, immune checkpoints, and exposure to autoantigens, microbes and vaccines. Recently, comparative deep sequencing studies of antibody repertoires between individuals have revealed the existence of public and private repertoires. Exploring genetic diversity of these repertoires and their impacts on the humoral immune response is the subject of active investigations that have tremendous applications, such as antibody discovery, immune profiling in disease conditions (ex., autoimmunity, cancer and viral infection) and following vaccination, and B-cell lineage-based approach to vaccine design.
This Special Issue of Antibodies focuses on recent advances in antibody repertoire mining from human and other organisms, including, high-throughput single B cell technologies for antibody discovery, NGS data mining pipeline and in silico analysis for clone selection and improved antibody library generation, evolutionary and developmental aspects of B-cell receptor repertoires, maturation pathway analysis for vaccine design, and understanding immunogenetic and molecular basis of antibody responses at the repertoire level to pathogens, vaccines and autoantigens.
Dr. Prabakaran Ponraj
Dr. Brandon J Dekosky
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibodies is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Next-generation sequencing of antibodies
- B-cell receptor repertoire