SIgA in Mucosal Immunity
A special issue of Antibodies (ISSN 2073-4468).
Deadline for manuscript submissions: closed (31 July 2015) | Viewed by 6746
Interests: plant and bacterial toxins; antibodies; vaccines; pathophysiology; biodefense
Special Issues, Collections and Topics in MDPI journals
Secretory IgA (SIgA) is frequently described as serving as the first line of defense against mucosal pathogens, especially in the gastrointestinal tract where IgA concentrations can exceed milligrams per milliliter in secretions. However, despite a widespread appreciation of the importance of SIgA in mucosal immunity, very little is actually known about the details of how secretory antibodies function in preventing pathogens from colonizing and invading the mucosal compartments. The concept of immune exclusion still holds, but it is increasingly apparent that SIgA does more than physically entrap bacteria (and viruses) in external environment. It is also increasing evident that SIgA plays a critical role in keeping the microbiota in check and thereby preventing the onset of potentially chronic inflammatory diseases. This Special Issue of Antibodies is dedicated to all things SIgA, and in illuminating the importance of secretory antibodies in mucosal protection. I invite you to contribute to this issue and stimulate the discourse and to aide in advancing our understanding of SIgA.
Dr. Nicholas J. Mantis
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibodies is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- secretory component
- antibody transport
- antibody effector function
- mucus, breast milk