Half-Life Extension of Therapeutic Antibodies
A special issue of Antibodies (ISSN 2073-4468).
Deadline for manuscript submissions: closed (10 April 2022) | Viewed by 308
Interests: therapeutic proteins; antibodies; Fc receptor biology; FcRn; antibody recycling mechanism; mechanism of action; affinity determination technologies; surface plasmon response; affinity column chromatography; protein folding
The number of therapeutic antibodies in clinical development has been continuously increasing over the last several decades. Monoclonal therapeutic antibodies are established as classical immunoglobulin G (IgG)-like scaffolds such as more complex formats with novel functions and differentiated mechanisms of action. IgG1, the most abundant isotype, has the longest half-life amongst the immunoglobulins due to the pH-dependent active FcRn-mediated recycling mechanism. This Special Issue of Antibodies aims to collect original manuscripts and reviews covering the attempts made so far to engineer IgG-based formats for significant half-life extensions, including the research activity that was needed to understand this mechanism in more detail to repair unexpected fast clearance of complex novel IgG-based formats.
Dr. Tilman Schlothauer
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibodies is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- FcRn recycling;
- half-life extension;
- complex Fc based formats;
- modulating clearance