Special Issue "Antibiotic Usage in Acute Situations"
Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 35426
Interests: antibiotic administration (particularly pharmacokinetics); pharmacodynamics; clinical trials
Special Issues, Collections and Topics in MDPI journals
Special Issue in Antibiotics: Feature Paper in Antibiotics for 2019
Special Issue in Antibiotics: A Themed Issue in Honor of Professor Jordi Rello—Outstanding Contributions in the Fields of Management of Severe Infections and Sepsis
Antibiotics kill bacteria, depending on how much of the drug reaches and eliminates the susceptible bacteria.
Whenever I prescribe an antibiotic, two issues come to mind.
Firstly, the “O’Neil report”, which suggested that by 2050, 10 million lives a year and a cumulative 100 trillion USD of economic output will be at risk due to the rise of drug-resistant infections if proactive solutions are not found to slow down the rise of drug resistance. It proposed that, by then, more patients will die from resistant infections than from cancer.
The other statement that I am often cognisant of is that attributed to Einstein: doing the same thing over and over and expecting different results is the definition of insanity.
Putting these thoughts into context, we should be using antibiotics when appropriate, at the appropriate dose. The unnecessary use of antibiotics not only subjects patients to drug side-effects, it drives bacterial resistance. Inappropriate dosing allows for bacterial growth, with concomitant poor outcomes.
Keeping these issues in mind, within the acute setting of the Intensive Care Unit, each day, we grapple with various decisions: firstly, when to start antibiotics, i.e., most of our patients will have a temperature and raised white blood cell count, and secondly, how to dose each patient appropriately.
The syndromes of inflammation in ICU are often difficult to differentiate from infections. In this edition of Antibiotics, a number of manuscripts will describe these differences and shed light on not only when to use antibiotics, but when not to use such important drugs unnecessarily. The second section of the edition concentrates on the appropriate dosing of antibiotics in acute settings, getting enough of the drug to the site of the proposed infection.
Prof. Dr. Jeffrey Lipman
Prof. Dr. Jason Roberts
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- critical care