Special Issue "Natural Product-Based Antibiotics: Synthesis and Activity against Infections"

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: 31 March 2024 | Viewed by 137

Special Issue Editors

Microbiology, Bioorganic and Macromolecular Chemistry Unit, Faculty of Pharmacy, Université Libre de Bruxelles (ULB), 1050 Bruxelles, Belgium
Interests: Mycobacterium; antibiotics tolerance and resistance; cytotoxicity; antimicrobial assays
Special Issues, Collections and Topics in MDPI journals
Équipe “Pharmacognosie-Chimie des Substances Naturelles” BioCIS, CNRS, Université Paris-Saclay, 92290 Châtenay-Malabry, France
Interests: natural products; chemoinformatics; metabolomics pipelines
Special Issues, Collections and Topics in MDPI journals
Microbiology, Bioorganic and Macromolecular Chemistry Unit, Faculty of Pharmacy, Université Libre de Bruxelles (ULB), 1050 Bruxelles, Belgium
Interests: medicinal chemistry related to pathogens and cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Multidrug-resistant infections are gradually becoming a major concern for global public health. This threat requires urgent multisectoral actions, including the development of novel anti-infectious strategies and new antibacterial compounds.

Natural products represent a major source of treatment, and  have been used by humans for more than 5000 years. Over the last 95 years, purified natural antibiotics, or even their derivatives, obtained by synthesis, have also been used, representing the majority of the drugs approved today. So, nature is clearly a dynamic research field that aims to discover and create new antimicrobial compounds.

When testing natural metabolites, researchers are not only looking for those with interesting antimicrobial activity, but also for the rare pearl that will not have too much cytotoxic activity on mammalian cells. The selective toxicity towards microorganisms is an important matter, helping to save time and money for the most promising drug candidates.

The revealed microbial molecular pathways involved in drug tolerance, resistance, and biofilm formation can also provide innovative screening tools to discover natural inhibitors or derivatives which can target key pathways involved in microbial surviving mechanisms.

We hope that this Special Issue will provide you with new opportunities to present your innovative results. This Special Issue aimed to expand our knowledge on natural products-based antimicrobial compounds and their activities to selectively target pathogens.

Dr. Veronique Fontaine
Prof. Dr. Mehdi A. Beniddir
Dr. Francois Dufrasne
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • natural products
  • chemical synthesis
  • antimicrobial activity
  • selectivity
  • cytotoxicity
  • anti-biofilm activity

Published Papers

This special issue is now open for submission.
Back to TopTop