Special Issue "Clostridioides difficile Infection"
A special issue of Antibiotics (ISSN 2079-6382).
Deadline for manuscript submissions: closed (15 May 2021) | Viewed by 24868
A printed edition of this Special Issue is available here.
Interests: immune response; immunodeficiency disorders; host-pathogen interaction; host and microbiota interaction; Clostridioides difficile infection; antimicrobial resistance; antimicrobial treatment
Special Issues, Collections and Topics in MDPI journals
Special Issue in Antibiotics: Clostridioides difficile Infection, 2nd Volume
Special Issue in Life: Targeting the Gut during Infections: From Bench to Bedside
Special Issue in Journal of Clinical Medicine: Clostridium difficile Infection: Unmet Needs and Unsolved Questions: Part II
Special Issue in Antibiotics: Antibiotic Use in Clostridioides difficile Infection, Mechanisms of Resistance and Alternative Treatments
The Gram-positive, anaerobic bacterium Clostridioides difficile (CD) represents the commonest cause of nosocomial diarrhea worldwide and is responsible for increased morbidity, mortality, and prolonged hospital stay. The focus of this Special Issue includes any aspects concerning Clostridioides difficile infection (CDI). Indeed, there is the need for studies to clarify some important aspects of this complex disease.
First, the intestinal burden of CD has a significant impact on its hospital spread. The persistent shedding of CD even after the completion of anti-CDI antimicrobial therapy significantly contributes to CD transmission. Understanding the routes of in-hospital and community CD transmission is crucial to develop specific interventions to reduce the spread of CDI.
A further issue is the definition and validation of antimicrobial stewardship programs on CD prevention, considering that antimicrobial stewardship programs may reduce CDI incidence.
No less important is the high recurrence rate observed with the currently available CDI therapy. The alarming rate of CDI recurrence urges the proposal and the evaluation of innovative therapeutic approaches.
Finally, many advances in our knowledge of CDI pathogenesis and the role of intestinal microbiota have been recently made. Studies on the innate and adaptive immune response towards CD and on the interplay between CD and other microbiota components may further clarify the complex interaction between CD and the host.
Dr. Guido Granata
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Clostridioides difficile
- Clostridioides difficile infection recurrence
- Antimicrobial use
- Host and Microbiota Interaction