Emerging Topics in Clostridioides difficile Infection: A One Health Problem

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotic Therapy in Infectious Diseases".

Deadline for manuscript submissions: 20 September 2024 | Viewed by 1076

Special Issue Editor


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Guest Editor
Department of Clinical, Pharmaceutical & Biological Science, University of Hertfordshire, Hatfield AL10 9AB, UK
Interests: clostridioides difficile; in vitro/models; gut microbiology

Special Issue Information

Dear Colleagues,

Clostridium difficile infection (CDI) remains a substantial worldwide burden on healthcare systems, despite significant research and investment over the past four decades. We extend a warm invitation for comprehensive studies focusing on C. difficile isolation, characterization, and epidemiology in humans, animals, and the environment.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: AMR transmission and assessment, environmental sampling, animal transmission/infection studies, antimicrobial prescribing studies and their effect on C. difficile infection, transmission and carriage in humans and animals, and assessment of C. difficile contamination of foodstuffs. We also welcome submissions involving fundamental science laboratory studies, in vivo animal and human studies, or modeling studies.

We look forward to receiving your contributions.

Dr. Simon D. Baines
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • clostridium difficile infection (CDI)
  • antimicrobial resistance (AMR)
  • antimicrobial prescribing
  • one health
  • laboratory studies

Published Papers (1 paper)

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Review

14 pages, 654 KiB  
Review
Environmental and Nutritional Parameters Modulating Genetic Expression for Virulence Factors of Clostridioides difficile
by Zoe Masset, Sathursha Gunaratnam, Mathieu Millette, Lynne V. McFarland and Monique Lacroix
Antibiotics 2024, 13(4), 365; https://doi.org/10.3390/antibiotics13040365 - 16 Apr 2024
Viewed by 871
Abstract
Clostridioides difficile infections (CDIs) continue to be a persistent healthcare concern despite newer antibiotic treatments, enhanced infection control practices, and preventive strategies focused on restoring the protective intestinal microbial barrier. Recent strides in gene sequencing research have identified many genes regulating diverse virulence [...] Read more.
Clostridioides difficile infections (CDIs) continue to be a persistent healthcare concern despite newer antibiotic treatments, enhanced infection control practices, and preventive strategies focused on restoring the protective intestinal microbial barrier. Recent strides in gene sequencing research have identified many genes regulating diverse virulence factors for CDIs. These genes may be over- or under-expressed when triggered by various environmental and nutritional factors. The aims of this paper are to review the important genes involved in C. difficile pathogenesis and to identify modifiable environmental, nutritional, and other factors that may trigger the expression of these genes and thus offer new strategies to prevent CDIs. Full article
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