Special Issue "Design and Synthesis of Antimicrobial Compounds"
Deadline for manuscript submissions: 29 February 2024 | Viewed by 3671
Interests: syntheses of biologically active compounds; heterocycles (benzimidazoles, octahydroacridines, pyrimidines, pyrazoles); DFT; the correlation between the structure of the compounds and their antimicrobial activity; syntheses of compounds with nonlinear optical properties (NLO)
Interests: synthesis; spectral characterization; anti-tumor activity of some pyrazole derivatives
Interests: antibiotics; ribosome structure and function; protein biosynthesis; antibiotics development and evaluation; Chloramphenicol Derivatives
Special Issues, Collections and Topics in MDPI journals
Since the discovery and clinical application of penicillin, microbial natural products have played a critical role in protecting public health. However, the emergence and wide spread of drug-resistant pathogens pose a new grave threat to humankind and make it one of the world’s most severe public health problems. New chemical entries with antimicrobial activities, new mechanisms, or novel therapy methods are urgently needed for drug development. By exploring new sources, new technology in separation and structure elucidation, genome mining and synthetic biology, natural product research is entering a new golden age.
This Special Issue on natural products with antimicrobial activity will cover, though is not limited to, the discovery of new secondary metabolites, new mechanisms and new therapy methods related to potential applications in antimicrobial drug screening and development.
The synthesis, characterization and evaluation of the antimicrobial properties of organic or coordination compounds is the first step in realizing new antimicrobial agents. Bioinformatic analysis and the study of redox properties and reaction mechanisms help in understanding, redesigning and optimizing the characteristics of potential active molecules for fighting microorganisms (bacteria, fungi, and viruses).
At the moment, infection by the virus SARS-CoV-2 is a threat clearly perceived all over the world. Less widespread and broadcasted is the concern regarding microorganisms such as bacteria and fungi, especially for those with depleted immune systems. According to the European Centre for Disease Control, 3.8 million people acquire healthcare-associated infections and ca. 90,000 people die from them per year (data from 2018) in the EU.
The aim of this Special Issue is to put together relevant research on molecules that have the potential to contribute to reducing the number of fatalities caused by bacteria or fungi, as well as controlling microorganisms on agricultural crops and food.
Dr. Maria Marinescu
Dr. Christina Marie Zalaru
Dr. George Dinos
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- heterocyclic compounds
- antimicrobial activity
- antibiotic resistance
- antimicrobial mechanisms
- antibiotic targetsclinical applications
- antibiotic development