Special Issue "Structures and Functions of Antimicrobial Peptides"
Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 7124
Interests: structural bioinformatics; computational structural biology; quantitative biomedical research; protein mutation interpretation; protein-peptide docking; protein-protein interactions; molecular caging prediction; integrative molecular modelling
Antimicrobial peptides (AMPs) are a diverse group of naturally-occurring molecules involved in the innate immune response of all multicellular organisms, but also produced by microbes to defend their environmental niche. They are potent antibiotics that can directly kill or inhibit the growth of foreign micro-organisms (such as bacteria, viruses, parasites, fungi, or yeasts), but also diseased cells, tumors, or biofilms. AMPs are often referred to as “host defense peptides” because of their various activities in modulating host cellular immunity in higher eukaryotic organisms. Recently, it has even been shown that AMPs can influence the composition of the microbiome in mammals. Interest in AMPs has been strongly renewed by the growing problem of bacterial resistance to conventional antibiotics. AMPs have the potential to become the next generation of prescribed anti-infection molecules, thanks to their more selective effects on pathogens. This Special Issue will focus on the analysis of the structure and function of AMPs and similar peptide-based drugs, as well as the various implications of such studies.
All submission types, including original research articles and comprehensive reviews, are welcome. Topics covered by this Special Issue include, but are not limited to the following:
- Structural diversity of AMPs
- Structural classification of AMPS
- Inter-species comparative studies
- Evolutionary conservation of structural features
- Impact of structure on the mechanisms of action
- AMP binding/docking
- AMP interactions with pathogens
- Relationships between structure and expression/regulation
- Antibiotic specificity/selectivity
- Dynamic properties of AMPs
- Role of flexibility in AMP activity
- Cyclic/branched peptides
- Post-translational modifications in AMPs
- Peptide-based degradation
- Anti-cancer peptides
- Anti-biofilm peptides
Dr. Didier Devaurs
Dr. Dinler Amaral Antunes
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Antimicrobial peptide
- host defense peptide
- peptide-based drug
- host immunity modulation
- antibiotic resistance
- antibiotic specificity
- microbiome regulation
- peptide immunotherapy
- structural modeling
- structure–function relationship