Multidrug-Resistant Organisms (MDROs) in Solid Organ Transplants and the Use of New Beta-lactam Antibiotics

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotic Therapy in Infectious Diseases".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 94

Special Issue Editor


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Guest Editor
Department of Molecular Medicine, University of Padua, 35122 Padova, Italy
Interests: anti-infectives; antibiotic treatment

Special Issue Information

Dear Colleagues,

Solid organ transplantation (SOT) has revolutionized the treatment of end-stage organ failure, offering hope and extended life to thousands of patients worldwide. However, the success of transplantation is threatened by the emergence and spread of multidrug-resistant organisms (MDROs), which can cause increased morbidity and mortality. These infections can lead to graft loss, sepsis, longer hospital stays, and reduced long-term graft and patient survival. MDROs may also complicate immunosuppressive therapy by limiting antibiotic options and necessitate the application of broad-spectrum agents, which can affect the microbiome and promote further resistance.

Addressing this challenge requires a multifaceted approach, including stringent infection control measures, programs of antimicrobial stewardship, and the development of new antibiotics with novel mechanisms of action. The recent development of novel B-lactam antibiotics, such as ceftazidime-avibactam, cefolozane/tazobactam, and cefiderocol, represents a valuable addition to the antibiotic armamentarium in the treatment of MDRO infections, especially in critically ill patients.

However, these agents need to be thoroughly evaluated and largely experienced in the context of SOT.

This Special Issue aims to explore and improve knowledge regarding the efficacy and safety profiles of these new drugs, considering (i) the drug interactions, side effects, and potential complications associated with immunosuppression; (ii) optimal drug combinations; and (iii) the choice of a first-line empiric therapy.

The scope of this Special Issue includes, but is not limited to, the following topics:

  1. Epidemiology of MDROs in SOT;
  2. Risk factors and outcomes of MDROs in SOT;
  3. Antibiotic stewardship in the SOT setting;
  4. Management of Carbapenem-resistant Enterobacteriaceae in SOT;
  5. Monotherapy and association therapy using new beta-lactamase antibiotics;
  6. New (other than the last beta-lactamase) therapeutic options against MDROs in SOTs.

Dr. Annamaria Cattelan
Guest Editor

Manuscript Submission Information

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Keywords

  • solid organ transplant
  • multidrug-resistant pathogens
  • carbapenem-resistant gram-negative bacilli
  • vancomycin-resistant enterococci
  • novel β-lactam antibiotics

Published Papers

There is no accepted submissions to this special issue at this moment.
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