Special Issue "Optimizing Antibiotics’ Pharmacokinetic/Pharmacodynamic (PK/PD) and Tissue Concentrations"
Deadline for manuscript submissions: 20 February 2024 | Viewed by 16994
Interests: infection control in the critically ill; multi-resistant bacteria; rapid detection; antibiotic therapy
Low target tissue concentrations of antibiotics are associated with incomplete clinical response and the emergence of multi-drug-resistant (MDR) pathogenic bacteria. Treating increasingly resistant bacteria cannot be based only on the development of new drugs. Optimization of dosage regimen of old drugs and drug combinations offer interesting alternatives to costly new drugs. Pharmacokinetic/pharmacodynamic (PK/PD) parameters can optimize tissue concentrations and predict the clinical antibacterial efficacy. Conceptually, the appropriate application of PK/PD principles has potential to improve the outcomes, extending the usage life of available antibiotics.
Some infected tissues are studied today with more specific methods of measurement of tissue concentrations such as microdialysis, and the blood–brain barrier is intensively investigated to optimize central nervous system concentration of antibiotics.
Authors are invited to submit manuscripts of narrative and systematic reviews/meta-analysis within their area of interest including (but not limited to) the topics highlighted below:
- Betalactam optimization using pharmacokinetic/pharmacodynamic (PK/PD) properties.
- Aminoglycosides optimization using pharmacokinetic/pharmacodynamic (PK/PD) properties.
- Pharmacokinetic/pharmacodynamic (PK/PD) of antibiotics in obese patients.
- Pharmacokinetics of antibiotics in subjects with renal impairment.
- Pharmacokinetics of antimicrobial therapy in elderly patients.
- Optimizing antibiotics pharmacokinetic-pharmacodynamic parameters in pediatric patients.
- Measurement of Free Plasma Concentrations of antibiotics.
- Measuring tissue antibiotic concentrations using microdialysis.
- Blood–brain barrier and pharmacokinetic/pharmacodynamic optimization of antibiotics.
- Pharmacokinetics and Tissue Penetration of antibiotics in diabetic patients.
- Nebulized antibiotics (aminoglycosides and colistin) in respiratory infections.
Dr. Mehran Monchi
Dr. Sylvain Diamantis
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- antimicrobial therapy
- pharmacokinetic/pharmacodynamic (PK/PD)
- free plasma concentrations
- blood-brain barrier
- renal impairment
- nebulized antibiotics