Diagnosis and Antimicrobial Therapy of Osteoarticular Infection

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotic Therapy in Infectious Diseases".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 1031

Special Issue Editor


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Guest Editor
International Center for Limb Lengthening, Rubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore, Baltimore, MD 21215, USA
Interests: bone infection; joint infection; periprosthetic joint infection; limb lengthening; bone reconstruction

Special Issue Information

Dear Colleagues,

Orthopedic infections represent a pivotal and costly facet in the management of bone and joint disorders. Despite substantial efforts to address this issue through the development of diagnostic and therapeutic methods, lingering questions persist, impeding the attainment of favorable outcomes in these operations. We extend a warm invitation for comprehensive studies focusing on the Diagnosis and Antimicrobial Therapy of Osteoarticular Infection. This Special Issue welcomes original research. By fostering a diverse range of studies, we aim to advance our understanding and enhance the effectiveness of interventions in the complex realm of orthopedic infections.

Dr. Janet D. Conway
Guest Editor

Manuscript Submission Information

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Keywords

  • bone infection
  • joint infection
  • periprosthetic joint infection
  • orthopaedic infection
  • orthopedic infection

Published Papers (1 paper)

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Research

15 pages, 1862 KiB  
Article
Differences in the Synovial Fluid Proteome of Septic and Aseptic Implant Failure
by Andrea Sowislok, André Busch, Farnusch Kaschani, Markus Kaiser and Marcus Jäger
Antibiotics 2024, 13(4), 346; https://doi.org/10.3390/antibiotics13040346 - 9 Apr 2024
Viewed by 839
Abstract
Implant loosening is a severe complication after total joint replacement. Here, differential diagnosis between septic and aseptic cases is crucial for further surgical treatment, but low-grade periprosthetic joint infections (PJIs) in particular remain a challenge. In this study, we analyzed the synovial fluid [...] Read more.
Implant loosening is a severe complication after total joint replacement. Here, differential diagnosis between septic and aseptic cases is crucial for further surgical treatment, but low-grade periprosthetic joint infections (PJIs) in particular remain a challenge. In this study, we analyzed the synovial fluid proteome of 21 patients undergoing revision surgery for septic (eight cases) or aseptic (thirteen cases) implant failure using LC-MS/MS to identify potential new biomarkers as future diagnostic tools. Staphylococci were found in four cases, Streptococci in two cases, Serratia marcescens and Cutibacterium acnes in one case. Proteomic analysis of the synovial fluid resulted in the identification of 515 different proteins based on at least two peptides. A statistical comparison revealed 37 differentially abundant proteins (p < 0.05), of which 17 proteins (46%) showed a higher abundance in the septic group. The proteins with the highest fold change included the known marker proteins c-reactive protein (7.57-fold) and the calprotectin components protein S100-A8 (4.41-fold) and protein S100-A9 (3.1-fold). However, the protein with the highest fold change was leucine-rich alpha-2-glycoprotein 1 (LRG1) (9.07-fold), a currently discussed new biomarker for inflammatory diseases. Elevated LRG1 levels could facilitate the diagnosis of PJI in the future, but their significance needs to be further investigated. Full article
(This article belongs to the Special Issue Diagnosis and Antimicrobial Therapy of Osteoarticular Infection)
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