Design, Synthesis and Biological Evaluation of Antibacterial Compounds

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: 15 October 2024 | Viewed by 1218

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School of Cancer & Pharmaceutical Sciences, King's College London, London, UK
Interests: drug discovery; medicinal chemistry; antimicrobial resistance
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Special Issue Information

Dear Colleagues,

Antimicrobial resistance (AMR) represents a significant challenge to future healthcare provision. The pipeline of antibiotics is essentially empty, and very few compounds are even in early-stage clinical trials. The development of novel antimicrobial agents for treating infections caused by multidrug-resistant (MDR) Gram-negative pathogens is an urgent priority. The high cost of drug development, coupled with a relatively short window of use to gain a return on investment, has resulted in a waning interest in antibiotic discovery among many pharmaceutical companies. The lack of new chemical scaffolds with antibiotic activity has further compounded the problem, leading to a discovery void. Therefore, it is important to innovate and disseminate information about antimicrobial chemical scaffolds to the wider scientific community. With this in mind, we have launched a Special Issue on the “Design, Synthesis and Biological Evaluation of Antimicrobial Compounds” with a submission deadline of June 2023. This Special Issue will focus on primary research articles describing the synthesis and microbiological evaluation of new chemical scaffolds with antimicrobial activities; however, we will also welcome review articles that provide critical analysis of antimicrobial drug discovery efforts and the current state of the field.

Prof. Dr. Khondaker Miraz Rahman
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

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Keywords

  • antibacterial agents
  • antifungal agents
  • antibiotics
  • antimicrobial resistance
  • drug discovery
  • medicinal chemistry

Published Papers (1 paper)

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Research

24 pages, 5852 KiB  
Article
Antimicrobial Efficacy of 7-Hydroxyflavone Derived from Amycolatopsis sp. HSN-02 and Its Biocontrol Potential on Cercospora Leaf Spot Disease in Tomato Plants
by Halaswamy Hire Math, Raju Suresh Kumar, Bidhayak Chakraborty, Abdulrahman I. Almansour, Karthikeyan Perumal, Girish Babu Kantli and Sreenivasa Nayaka
Antibiotics 2023, 12(7), 1175; https://doi.org/10.3390/antibiotics12071175 - 11 Jul 2023
Cited by 1 | Viewed by 949
Abstract
The actinomycete strain HSN-02 was isolated from the soil of a mining field in the Sandur region, Bellary, Karnataka, India. According to the morphological, cultural, physiological, and biochemical characteristics and the 16S rDNA sequence analysis, the strain HSN-02 was identified as Amycolatopsis sp. [...] Read more.
The actinomycete strain HSN-02 was isolated from the soil of a mining field in the Sandur region, Bellary, Karnataka, India. According to the morphological, cultural, physiological, and biochemical characteristics and the 16S rDNA sequence analysis, the strain HSN-02 was identified as Amycolatopsis sp. The antimicrobial activity strain HSN-02 presented stable and moderate inhibitory activity against human pathogens. In pot experiments in the greenhouse, the development of Cercospora leaf spot was markedly suppressed by treatment with the purified compound from the strain HSN-02, and the control efficacy was 45.04 ± 1.30% in Septoria lycopersici-infected tomato plants. A prominent compound was obtained from the fermentation broth of the strain HSN-02 using column chromatography and HPLC. The chemical structural analyses using UV, FTIR, HR-ESI-MS, and NMR confirmed that the compound produced by the strain HSN-02 is 7-hydroxyflavone. This investigation showed the role which the actinomycete strain can play in controlling leaf spots caused by S. lycopersici to reduce treatments with chemical fungicides. Full article
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