Current Trends, Recent Advances and Applications of Outpatient Parenteral Antimicrobial Therapy (OPAT)

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotic Therapy in Infectious Diseases".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 2012

Special Issue Editors


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Guest Editor
1. Department of Infection and Tropical Medicine, Royal Hallamshire Hospital, Sheffield, UK
2. Department of Microbiology, Royal Derby Hospital, Derby, UK
Interests: outpatient parenteral antimicrobial therapy (OPAT); infectious diseases; viral hepatitis; bone and joint infections

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Guest Editor
Department of Infection, Immunity & Cardiovascular Diseases, University of Sheffield and Sheffield Teaching Hospitals, Sheffield, UK
Interests: infectious diseases; COVID medicines delivery unit (CMDU)

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Guest Editor
1. School of Medicine, University of Crete, Crete, Greece
2. School of Health and Related Research, University of Sheffield, Sheffield, UK
Interests: medical statistics; epidemiological methods; healthcare epidemiology; infection control; antimicrobial resistance; surveillance; public health
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Special Issue Information

Dear Colleagues,

Over the past few decades, we have seen significant changes in the delivery of healthcare from hospitals to community and home settings due to technological advancements, changes in medical culture, and efforts to manage costs and patient preferences. A major advancement to this changing environment has been the development of outpatient parenteral antimicrobial therapy (OPAT) programs to treat, in a safe and efficient manner, a wide variety of infections in selected patients.

This Special Issue welcomes high-quality papers that highlight advances, innovations, and new applications of OPAT. Original research, systematic reviews, scoping reviews, short communications, case series, and perspectives will be invited.

Topics may include but are not limited to:

  • National and international surveys of OPAT practices;
  • Safety, effectiveness, and clinical utility of new antimicrobial agents, models, and bundles for OPAT;
  • Health-related quality of life (HRQoL) assessments for patients receiving OPAT;
  • Changes in modes of OPAT delivery;
  • Head-to-head studies comparing OPAT with other related models such as hospital in the home services;
  • OPAT for new populations, including incurable infection or infections at the end of life and difficult-to-reach groups such as people who inject drugs and those who are homeless;
  • Challenges of antimicrobial stewardship in the context of OPAT;
  • Quality indicators for antibiotic prescribing in OPAT; and
  • Drug stability of antibiotic agents used for extended infusions.

Dr. Oyewole Christopher Durojaiye
Dr. Joby Cole
Dr. Evangelos I. Kritsotakis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • OPAT
  • outpatient parenteral antibiotics
  • home intravenous antibiotics
  • antimicrobial stewardship
  • intravenous therapy
  • outpatients
  • antimicrobials

Published Papers (1 paper)

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Research

11 pages, 1292 KiB  
Article
Real-Life Experience of Continuously Infused Ceftolozane/Tazobactam in Patients with Bronchiectasis and Multidrug-Resistant Pseudomonas aeruginosa Infection in the Outpatient Setting
by Francesco Venuti, Alberto Gaviraghi, Amedeo De Nicolò, Giacomo Stroffolini, Bianca Maria Longo, Alessia Di Vincenzo, Fabio Antonino Ranzani, Matilde Quaranta, Francesca Romano, Eleonora Catellani, Carlotta Marchiaro, Giacoma Cinnirella, Antonio D’Avolio, Stefano Bonora and Andrea Calcagno
Antibiotics 2023, 12(7), 1214; https://doi.org/10.3390/antibiotics12071214 - 21 Jul 2023
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Abstract
(1) Background: Ceftolozane/tazobactam (C/T) is a novel β-lactam/β-lactamase inhibitor with excellent activity against the multidrug-resistant (MDR) P. aeruginosa. Continuous infusion (CI) dosing allows the optimization of pharmacokinetic and pharmacodynamic (PK/PD) properties of β-lactam antibiotics and may support patients’ treatment as outpatients. (2) [...] Read more.
(1) Background: Ceftolozane/tazobactam (C/T) is a novel β-lactam/β-lactamase inhibitor with excellent activity against the multidrug-resistant (MDR) P. aeruginosa. Continuous infusion (CI) dosing allows the optimization of pharmacokinetic and pharmacodynamic (PK/PD) properties of β-lactam antibiotics and may support patients’ treatment as outpatients. (2) Methods: Adult patients receiving their entire course of C/T as a CI in the outpatient setting were retrospectively included in the study. The primary outcome evaluated was clinical resolution. The secondary outcomes evaluated were PK/PD target attainment (ƒT > 4 × MIC) and microbiologic clearance at the end of treatment. Therapeutic drug monitoring to assess C/T concentration was performed. (3) Results: Three patients were enrolled in the study and received 9 g of C/T in CI every 24 h. One patient received an additional course of antimicrobial therapy due to disease exacerbation six months after initial treatment, accounting for four evaluated treatments. The primary outcome was achieved in 3/4 treatments and the secondary outcome was achieved in 4/4 and 3/3, respectively. In all patients, free ceftolozane concentrations were >10 times higher than the EUCAST breakpoint (4 mg/L). (4) Conclusions: Elastomeric infusion of C/T delivered in CI can be an effective and convenient way to treat acute diseases caused by MDR-P. aeruginosa, avoid hospital admission, and contribute to infection control strategies. Despite the small number of enrolled patients, clinical and microbiological results support this strategy. Full article
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