Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.5
4.8
Journals
Antibiotics
Special Issues
Antimicrobial Properties of Green Synthesized Nanomaterials
share announcement

Antimicrobial Properties of Green Synthesized Nanomaterials

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antimicrobial Materials and Surfaces".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 7832

Special Issue Editor

Dr. Ernestina Castro-Longoria

E-Mail Website
Guest Editor
Department of Microbiology, Center for Scientific Research and Higher Education of Ensenada (CICESE), Carr. Tijuana-Ensenada 3918, Zona Playitas, Ensenada 22860, Baja California, Mexico
Interests: biosynthesis of metallic nanoparticles; antimicrobial properties of nanomaterials

Special Issue Information

Dear Colleagues,

Antimicrobial resistance is a global health problem; in recent decades, nanotechnology has contributed with possible alternatives to control the ability of microorganisms to withstand conventional antimicrobial treatments. It is well documented that metallic nanoparticles (NPs) possess antifungal, antiviral, antiparasitic, and antibacterial properties. However, their application to fight antimicrobial resistance may be limited by the cytotoxic effect they may have on animal cells. Therefore, more research is needed to determine safe concentrations for host cells, while maintaining the antimicrobial effect. The properties of metallic NPs will depend on the precursor metal, the synthesis process, size, shape and its surface capping. Due to the potential application of NPs in the biomedical area, the so-called green methods have been extensively studied. Green methods use biological sources such as plants, bacteria, fungi, yeasts and algae, among others, to produce nanomaterials. For many years, the most studied NPs for biomedical applications have been gold and silver. However, in the last decade, research has been extended to different nanomaterials in order to find alternatives with greater biocompatibility, less cytotoxicity and immunogenicity effects. This Special Issue seeks manuscript submissions that further explore and document the potential applications of green synthesized nanomaterials as antimicrobial agents. Submissions on the response of microorganisms to green synthesized nanomaterials and their corresponding cytotoxicity evaluation in animal cells are especially encouraged.

Dr. Ernestina Castro-Longoria
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • nanoparticles
  • green synthesis
  • biosynthesis
  • antimicrobial properties
  • antimicrobial resistance

Published Papers (4 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

17 pages, 5547 KiB  
Article
Antibacterial Activity of Biosynthesized Copper Oxide Nanoparticles (CuONPs) Using Ganoderma sessile
by Karla M. Flores-Rábago, Daniel Rivera-Mendoza, Alfredo R. Vilchis-Nestor, Karla Juarez-Moreno and Ernestina Castro-Longoria
Antibiotics 2023, 12(8), 1251; https://doi.org/10.3390/antibiotics12081251 - 29 Jul 2023
Cited by 7 | Viewed by 1874
Abstract
Copper oxide nanoparticles (CuONPs) were synthesized using an eco-friendly method and their antimicrobial and biocompatibility properties were determined. The supernatant and extract of the fungus Ganoderma sessile yielded small, quasi-spherical NPs with an average size of 4.5 ± 1.9 nm and 5.2 ± [...] Read more.
Copper oxide nanoparticles (CuONPs) were synthesized using an eco-friendly method and their antimicrobial and biocompatibility properties were determined. The supernatant and extract of the fungus Ganoderma sessile yielded small, quasi-spherical NPs with an average size of 4.5 ± 1.9 nm and 5.2 ± 2.1 nm, respectively. Nanoparticles were characterized by UV−Vis spectroscopy, transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), dynamic light scattering (DLS), and zeta potential analysis. CuONPs showed antimicrobial activity against Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), and Pseudomonas aeruginosa (P. aeruginosa). The half-maximal inhibitory concentration (IC50) for E. coli was 8.5 µg/mL, for P. aeruginosa was 4.1 µg/mL, and for S. aureus was 10.2 µg/mL. The ultrastructural analysis of bacteria exposed to CuONPs revealed the presence of small CuONPs all through the bacterial cells. Finally, the toxicity of CuONPs was analyzed in three mammalian cell lines: hepatocytes (AML-12), macrophages (RAW 264.7), and kidney (MDCK). Low concentrations (<15 µg/mL) of CuONPs-E were non-toxic to kidney cells and macrophages, and the hepatocytes were the most susceptible to CuONPs-S. The results obtained suggest that the CuONPs synthesized using the extract of the fungus G. sessile could be further evaluated for the treatment of superficial infectious diseases. Full article
(This article belongs to the Special Issue Antimicrobial Properties of Green Synthesized Nanomaterials)
►▼ Show Figures

Graphical abstract

14 pages, 3878 KiB  
Article
Controlled Size Oils Based Green Fabrication of Silver Nanoparticles for Photocatalytic and Antimicrobial Application
by Seemab Pervaiz, Iram Bibi, Wajid Rehman, Hadil Faris Alotaibi, Ahmad J. Obaidullah, Liaqat Rasheed and Mohammed M. Alanazi
Antibiotics 2023, 12(7), 1090; https://doi.org/10.3390/antibiotics12071090 - 22 Jun 2023
Viewed by 1355
Abstract
The particle size at the nanometric level allows the manifestation of remarkable properties, chiefly due to changes in surface-to-volume ratio. This study is attributed to the novel green synthesis of nano silver by using essential oils as a capping and reducing agent. Clove [...] Read more.
The particle size at the nanometric level allows the manifestation of remarkable properties, chiefly due to changes in surface-to-volume ratio. This study is attributed to the novel green synthesis of nano silver by using essential oils as a capping and reducing agent. Clove oil, cinnamon oil, and cardamom oil were selected for the eco-friendly and low-cost fabrication of silver nanoparticles. The prepared nanoparticles were characterized by photoluminescence spectroscopy, FT-IR spectroscopy, X-Ray diffraction, energy dispersive X-ray spectroscopy, dynamic laser light scattering, thermogravimetric analysis, and transmission electron microscopy. It was found that samples prepared by using cinnamon oil (20 nm) and cardamom oil (12 nm) had smaller particle sizes as compared to those synthesized by using clove oil (45 nm). All the prepared samples exhibited very strong antimicrobial activities with a clear zone of inhibition (6–24 mm) against Staphylococcus aureus, Klebsiella pneumoniae, and Candida albicans. Very resilient photocatalytic activities of the samples were observed against Allura red and fast green dyes. It was concluded that the cinnamon oil-based system is the best size reducer and size homogenizer (less chances of agglomeration) as compared to clove oil and cardamom oil (more chances of agglomeration) for the synthesis of silver nanoparticles. Full article
(This article belongs to the Special Issue Antimicrobial Properties of Green Synthesized Nanomaterials)
►▼ Show Figures

Figure 1

17 pages, 4757 KiB  
Article
Fungal-Mediated Silver Nanoparticle and Biochar Synergy against Colorectal Cancer Cells and Pathogenic Bacteria
by Moath Alqaraleh, Khaled M. Khleifat, Maha N. Abu Hajleh, Husni S. Farah and Khaled Abdul-Aziz Ahmed
Antibiotics 2023, 12(3), 597; https://doi.org/10.3390/antibiotics12030597 - 16 Mar 2023
Cited by 4 | Viewed by 1900
Abstract
Background: Silver nanoparticles (AgNPs) are attractive substrates for new medicinal treatments. Biochar is pyrolyzed biomass. Its porous architecture allows it to hold and gather minuscule particles, through which nanoparticles can accumulate in its porous structure. This study examined AgNPs’ antibacterial and anticancer properties [...] Read more.
Background: Silver nanoparticles (AgNPs) are attractive substrates for new medicinal treatments. Biochar is pyrolyzed biomass. Its porous architecture allows it to hold and gather minuscule particles, through which nanoparticles can accumulate in its porous structure. This study examined AgNPs’ antibacterial and anticancer properties alone and combined with biochar. Methods: The fungus Emericella dentata was responsible for biosynthesis of AgNPs. The characterization of AgNPs using STEM images and a Zetasizer was carried out. Accordingly, the antibacterial and antiproliferation activity of AgNPs and biochar was studied using MIC and MTT assays, respectively. To evaluate the antiangiogenic and anti-inflammatory effects of AgNPs with biochar, VEGF and cytokines including TNF alpha, IL-6 and IL-beta were tested using an ELISA assay. Results: The size of the AgNPs ranged from 10 to 80 nm, with more than 70% of them being smaller than 40 nm. The combination of AgNPs and biochar enhanced the antibacterial activity against all tested bacteria. Furthermore, this combination showed antiproliferative properties against HT29 cancer cells with high selectivity to fibroblasts at low concentrations. AgNPs with biochar significantly reduced VEGF and proinflammatory cytokine expression levels. Conclusions: Biochar and AgNPs may be novel treatments for bacteria and colorectal cancer cells, according to the current findings. Full article
(This article belongs to the Special Issue Antimicrobial Properties of Green Synthesized Nanomaterials)
►▼ Show Figures

Figure 1

23 pages, 11747 KiB  
Article
Myco-Nanofabrication of Silver Nanoparticles by Penicillium brasilianum NP5 and Their Antimicrobial, Photoprotective and Anticancer Effect on MDA-MB-231 Breast Cancer Cell Line
by Muthuraj Rudrappa, Raju Suresh Kumar, Shashiraj Kareyellappa Nagaraja, Halaswamy Hiremath, Pooja Vidyasagar Gunagambhire, Abdulrahman I. Almansour, Karthikeyan Perumal and Sreenivasa Nayaka
Antibiotics 2023, 12(3), 567; https://doi.org/10.3390/antibiotics12030567 - 13 Mar 2023
Cited by 19 | Viewed by 2345
Abstract
Currently, the exploration of fungal organisms for novel metabolite production and its pharmacological applications is much appreciated in the biomedical field. In the present study, the fungal strains were isolated from soil of unexplored Yellapura regions. The potent isolate NP5 was selected based [...] Read more.
Currently, the exploration of fungal organisms for novel metabolite production and its pharmacological applications is much appreciated in the biomedical field. In the present study, the fungal strains were isolated from soil of unexplored Yellapura regions. The potent isolate NP5 was selected based on preliminary screening and identified as Penicillium brasilianum NP5 through morphological, microscopic, and molecular characterizations. Synthesis of silver nanoparticles from P. brasilianum was confirmed by the color change of the reaction mixture and UV-visible surface plasmon resonance (SPR) spectra of 420 nm. Fourier transform infrared (FTIR) analysis revealed the functional groups involved in synthesis. Atomic force microscopy (AFM) and transmission electron microscope (TEM) analysis showed aggregation of the NPs, with sizes ranged from 10 to 60 nm, an average particle size of 25.32 nm, and a polydispersity index (PDI) of 0.40. The crystalline nature and silver as the major element in NP5-AgNPs was confirmed by X-ray diffraction (XRD) and energy dispersive X-ray (EDX) analysis. The negative value −15.3 mV in Zeta potential exhibited good stability, and thermostability was recorded by thermogravimetric analysis (TGA). NP5-AgNPs showed good antimicrobial activity on selected human pathogens in a concentration-dependent manner. The MTT assay showed concentration-dependent anticancer activity with an IC50 of 41.93 µg/mL on the MDA-MB-231 cell line. Further, apoptotic study was carried out by flow cytometry to observe the rate of apoptosis. The calculated sun protection factor (SPF) value confirms good photoprotection capacity. From the results obtained, NP5-AgNPs can be used in the pharmaceutical field after successful in vitro clinical studies. Full article
(This article belongs to the Special Issue Antimicrobial Properties of Green Synthesized Nanomaterials)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-4
Back to TopTop