Evaluation of the Use of Antimicrobial Intravenous Limb Perfusion to Treat Septic Digital Lesions in Cattle: Why and How to Reduce the Use of These Drugs in Systemic and Local Therapy
A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Cattle".
Deadline for manuscript submissions: 12 February 2025 | Viewed by 1736
Special Issue Editors
Interests: equine surgery; farm animal surgery; equine emergency; laparoscopy; endoscopy
Interests: equine surgery; farm animal surgery; equine emergency; endoscopy; laparoscopy
Interests: farm animal surgery; digital dermatitis
Interests: equine surgery; equine laparoscopy; lameness; equine urogenital surgery
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Deep digital septic conditions and soft tissue infections of the bovine foot, such as interdigital phlegmon, are responsible for severe lameness, a consequent decrease in milk production and possible premature culling. Antimicrobial intravenous regional limb perfusion (IVRLP) is a well-established technique for treating or preventing orthopedic infections of equine distal limbs. Several clinical studies have investigated its use for the treatment of digital septic lesions that are also found in cattle. Currently, there are no antimicrobial drugs labeled for IVRLP in large animals.
The IVRLP method of antimicrobial delivery offers many advantages over systemic administration. Local administration provides particularly high antimicrobial concentrations at the site of infection and minimizes systemic diffusion and potential side effects. A reduction of the total dose compared with animal bodyweight and minimal systemic plasma concentrations of antimicrobial agents are suitable for decreasing milk levels in lactating dairy cattle. To preserve antimicrobial function, the responsible use of antimicrobial drugs and the procedure of local antimicrobial therapy such as IVRLP in the management of digital septic lesions in cattle are strongly recommended.
Different from systemic administration, IVRLP delivers high antimicrobial concentrations to the digital region with minimal systemic diffusion.
Furthermore, antimicrobial concentrations achieved by systemic administration are often nontherapeutic in a highly septic environment.
Dr. Vincenzo Varasano
Dr. Gianluca Celani
Prof. Dr. Carlo Maria Mortellaro
Dr. Lucio Petrizzi
Guest Editors
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Keywords
- interdigital phlegmon
- deep digital septic condition
- cattle
- intravenous regional limb perfusion
- antibiotics
