Infection, Immune Escape, and Pathogenic Mechanism of African Swine Fever Virus

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 1381

Special Issue Editor

Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China
Interests: virus; pathogenicity; innate immune; signaling pathway; host–virus interaction
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

African swine fever (ASF) is a notifiable animal disease of the World Organization for Animal Health. African swine fever virus (ASFV)-infected pigs have a high mortality approaching 100%, and ASF has dealt a heavy blow to the global pig industry since it was introduced into China in 2018. ASF has spread rapidly worldwide due to the lack of safe, effective, and quality-controlled vaccines. However, the pathogenesis, immune evasion, and immune protection mechanism of ASFV is not fully understood, which brings great difficulties to the research and development of a safe and efficient ASF vaccine. Therefore, it is urgent to study the infection and pathogenesis of ASFV as well as the molecular and cellular mechanisms of how ASFV escapes the host innate and adaptive immune responses. The aim of this Special Issue is to study the infection and pathogenesis of ASFV as well as the molecular and cellular mechanisms of how ASFV escapes the host innate and adaptive immune responses.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: 1) the function of ASFV genes, 2) mechanism of ASFV infection and pathogenicity, 3) mechanisms of ASFV negatively regulating innate immune, 4) mechanism of ASFV regulating inflammatory response, 5) mechanisms of ASFV regulating autophagy, 6) mechanisms of ASFV inducing cell death, and 7) molecular and cellular mechanism of immune protection against ASFV.

We look forward to receiving your contributions.

Dr. Li Huang
Guest Editor

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Keywords

  • ASF
  • ASFV
  • pathogenesis
  • immune evasion
  • immune protection
  • host–virus interaction

Published Papers (1 paper)

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Research

11 pages, 1604 KiB  
Article
Deletion of the CD2 Gene in the Virulent ASFV Congo Strain Affects Viremia in Domestic Swine, but Not the Virulence
by Andrey Koltsov, Sergey Krutko, Natalia Kholod, Mikhail Sukher, Sergey Belov, Alexey Korotin and Galina Koltsova
Animals 2023, 13(12), 2002; https://doi.org/10.3390/ani13122002 - 15 Jun 2023
Cited by 1 | Viewed by 958
Abstract
African swine fever (ASF) is an infectious disease that causes the most significant losses to the pig industry. One of the effective methods for combating this disease could be the development of vaccines. To date, experimental vaccines based on the use of live [...] Read more.
African swine fever (ASF) is an infectious disease that causes the most significant losses to the pig industry. One of the effective methods for combating this disease could be the development of vaccines. To date, experimental vaccines based on the use of live attenuated strains of the ASF virus (ASFV) obtained by the deletion of viral genes responsible for virulence are the most effective. Deletion of the EP402R gene encoding a CD2-like protein led to the attenuation of various strains of the ASFV, although the degree of attenuation varies among different isolates. Here we have shown that the deletion of the EP402R gene from the genome of a high-virulent Congo isolate did not change either the virulence of the virus or its ability to replicate in the swine macrophage cell cultures in vitro. However, in vivo, animals infected with ΔCongo-v_CD2v had a delay in the onset of the disease and viremia compared to animals infected with the parental strain. Thus, deletion of the CD2 gene in different isolates of the ASFV has a different effect on the virulence of the virus, depending on its genetic background. Full article
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