Advanced Biomarker Research in Animal Pathological States

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: 1 September 2024 | Viewed by 3177

Special Issue Editors


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Guest Editor
Department of Epizootiology and Clinic of Infectious Diseases, Faculty of Veterinary Medicine, University of Life Sciences, Lublin, Poland
Interests: immunology; flow cytometry; image cytometry; microbiome; immuno-oncology; animal leukocytes; animal biomarkers
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Co-Guest Editor
Department of Epizootiology, University of Life Sciences of Lublin, 20-950 Lublin, Poland
Interests: proteomics; metabolomics; animal infectious diseases; mass spectrometry; animal biomarkers

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Co-Guest Editor
Department of Epizootiology and Clinic of Infectious Diseases, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Głęboka 30, 20-612 Lublin, Poland
Interests: animal infectious diseases; proteomics; analysis of tear film; metabolomics; animal biomarkers; immunology

Special Issue Information

Dear Colleagues,

Since the causes of many important animal diseases are complex and multifactorial, identifying biomarkers or biomarker profiles is a matter of great importance in veterinary medicine. Biomarkers are particularly relevant in medical and veterinary research as they indicate biological processes and pathological states that can reveal a variety of health and disease issues. The discovery of novel biomarkers for animal diseases is a great challenge and can help in supporting therapeutic decisions, better disease characterization, and the definition of treatment clinical care and management programs. Identification of new biomarkers can also help in choosing the cancer treatment options that match the tumor profile of any patient. New technologies enable the identification of specific and sensitive biomarkers from the huge number of molecules present in tissues or body fluids.

Besides the enormous number of applications in animal therapy, the use of animal models may be of immense value in defining and understanding human disease.

The topics of the Special Issue will cover the current developments in biomarker discovery and will focus on the role of genomics, transcriptomics, proteomics, cytomics, and metabolomics in biomarker research for animal disease. Both original and review articles are welcome. Potential topics include but are not limited to the following: new methodologies and new analysis methods; the characterization, applications, and validation of biomarkers; food intake biomarkers; stress biomarkers; diagnostic and prognostic biomarkers in cancer; toxicity biomarkers; biomarkers of inflammation; fertility-associated biomarkers; and acute and chronic disease biomarkers in livestock and companion animals.

Dr. Urszula Lisiecka
Dr. Katarzyna Michalak
Dr. Stanisław Winiarczyk
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • animal biomarkers
  • biomarker characterization
  • biomarker applications
  • biomarker validation
  • food intake biomarkers
  • stress biomarkers
  • diagnostic and prognostic biomarkers in cancer
  • toxicity biomarkers
  • biomarkers of inflammation
  • fertility-associated biomarkers
  • acute and chronic disease biomarkers

Published Papers (2 papers)

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Research

13 pages, 2900 KiB  
Article
Examining the Effects of Hyperbaric Oxygen Therapy on the Cardiovascular System and Oxidative Stress in Insulin-Treated and Non-Treated Diabetic Rats
by Petar Ristic, Maja Savic, Sergey Bolevich, Stefani Bolevich, Alexandra Orlova, Anastasiya Mikhaleva, Anna Kartashova, Koka Yavlieva, Tamara Nikolic Turnic, Bozidar Pindovic, Katarina Djordjevic, Ivan Srejovic, Vladimir Zivkovic and Vladimir Jakovljevic
Animals 2023, 13(18), 2847; https://doi.org/10.3390/ani13182847 - 07 Sep 2023
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Abstract
Background: This study explored the effects of hyperbaric oxygen therapy (HBOT) on the cardiovascular system and oxidative stress in streptozotocin-induced diabetic rats. Wistar albino rats were divided into four groups: DM group (diabetic rats), DM+HBOT group (diabetic rats exposed to HBOT for 1 [...] Read more.
Background: This study explored the effects of hyperbaric oxygen therapy (HBOT) on the cardiovascular system and oxidative stress in streptozotocin-induced diabetic rats. Wistar albino rats were divided into four groups: DM group (diabetic rats), DM+HBOT group (diabetic rats exposed to HBOT for 1 h daily, five days a week, at 2.8 atmosphere absolute (ATA) with 100% oxygen for two weeks), DM+INS group (diabetic rats treated with neutral protamine hagedorn (NPH) insulin at a dosage of 3–5 U/day), and DM+HBOT+INS group (diabetic rats treated with both NPH insulin and HBOT for two weeks). Methods: Evaluations included glycemic control, oxidative stress parameters, and cardiac function measurements. Results: NPH insulin treatment reduced blood glucose levels, although normoglycemia was not achieved. The DM+HBOT+INS group demonstrated the lowest pro-oxidative marker levels. NPH insulin treatment improved cardiac function, and combination therapy effectively restored cardiac function in diabetic animals. Conclusions: NPH insulin treatment reduced hyperglycemia and improved cardiac function in diabetic rats. The combined approach of NPH insulin and HBOT resulted in decreased pro-oxidative markers. These findings provide valuable insights for managing cardiovascular complications and oxidative stress in diabetes. Full article
(This article belongs to the Special Issue Advanced Biomarker Research in Animal Pathological States)
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18 pages, 1259 KiB  
Article
Immunological and Oxidative Biomarkers in Bovine Serum from Healthy, Clinical, and Sub-Clinical Mastitis Caused by Escherichia coli and Staphylococcus aureus Infection
by Asmaa Sadat, Alshimaa M. M. Farag, Driss Elhanafi, Amal Awad, Ehab Kotb Elmahallawy, Noorah Alsowayeh, Manal F. El-khadragy and Gehad E. Elshopakey
Animals 2023, 13(5), 892; https://doi.org/10.3390/ani13050892 - 01 Mar 2023
Cited by 5 | Viewed by 2008
Abstract
The study aimed to investigate the mastitis’ emerging causative agents and their antimicrobial sensitivity, in addition to the hematological, biochemical indicators, oxidative biomarkers, acute phase protein (APP), and inflammatory cytokine changes in dairy farms in Gamasa, Dakahlia Governorate, Egypt. One hundred Holstein Friesian [...] Read more.
The study aimed to investigate the mastitis’ emerging causative agents and their antimicrobial sensitivity, in addition to the hematological, biochemical indicators, oxidative biomarkers, acute phase protein (APP), and inflammatory cytokine changes in dairy farms in Gamasa, Dakahlia Governorate, Egypt. One hundred Holstein Friesian dairy cattle with clinical and subclinical mastitis were investigated and were allocated into three groups based on a thorough clinical examination. Escherichia coli and Staphylococcus aureus were found responsible for the clinical and subclinical mastitis in dairy farms, respectively. Multiple drug resistance (MDR) was detected in 100%, and 94.74% of E. coli and S. aureus isolates, respectively. Significantly low RBCs count, Hb, and PCV values were detected in mastitic cows compared with both subclinical mastitic and control groups; moreover, WBCs, lymphocytes, and neutrophil counts were significantly diminished in mastitic cows compared to the controls. Significantly higher levels of AST, LDH, total protein, and globulin were noticed in both mastitic and subclinical mastitic cows. The haptoglobin, fibrinogen, amyloid A, ceruloplasmin, TNF-α, IL-1β, and IL-6 levels were statistically increased in mastitic cows compared to the controls. Higher MDA levels and reduction of TAC and catalase were identified in all the mastitic cases compared to the controls. Overall, the findings suggested potential public health hazards due to antimicrobial resistance emergence. Meanwhile, the APP and cytokines, along with antioxidant markers can be used as early indicators of mastitis. Full article
(This article belongs to the Special Issue Advanced Biomarker Research in Animal Pathological States)
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