Cancer in Animals: Surveillance and Risk Factors

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: closed (25 February 2024) | Viewed by 1701

Special Issue Editors

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Guest Editor
Population Studies Department, School of Medicine and Biomedical Sciences (ICBAS), University of Porto, 4099-002 Porto, Portugal
Interests: animal oncology; cancer epidemiology; comparative oncology; one health; animal diseases; surveillance
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Department of Veterinary Clinic, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu 01049-010, SP, Brazil
Interests: veterinary pathology; comparative oncology; target therapy

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Laboratory of Experimental and Comparative Oncology, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Av. Prof Dr. Orlando Marques de Paiva, 87, CEP 05508900 São Paulo, Brazil
Interests: cancer; carcinogenesis; cancer epidemiology; cancer etiology
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Institute of Public Health, University of Porto, R. das Taipas 135, Porto, Portugal
Interests: animal health management; ruminants; Paratuberculosis; Salmonella in swine

Special Issue Information

Dear Colleagues,

Cancer is considered the most significant global health problem and is one of the leading causes of death and disease in the 21st century. Cancer is also a common disease in companion animals, with over 4.2 million dogs and cats diagnosed with cancer each year, of which 15% to 30% die. In addition, a number of neoplastic diseases in companion animals share many similarities with humans in terms of biological behavior, dissemination, and response to therapy, placing them in a strategic position for more rapid studies.

Cancer surveillance in animals is an important process that goes well beyond simple registration of cancer cases or calculation of incidence rates to include studies of cancer determinants and the effectiveness of prevention strategies and screening programs. Animal cancer data can also provide research data that can be used for epidemiological, clinical, and public health planning research.

The purpose of this Special Issue is to report on recent studies in the field of veterinary epidemiology and animal cancer data. Original research articles and reviews are welcome in this Special Issue. Research areas include, but are not limited to: Epidemiology of animal cancer and global registry initiatives; practice- and pathology-based data collection; regional or international studies; animal and comparative environmental oncology; and risk factor research.

Dr. Katia Pinello
Dr. Chiara Palmieri
Dr. Renée Laufer-Amorim
Dr. Maria Lucia Zaidan Dagli
Dr. João Niza-Ribeiro
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • animal cancer
  • epidemiology
  • animal cancer data
  • cancer registry
  • comparative environmental oncology
  • surveillance
  • risk factors

Published Papers (1 paper)

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10 pages, 465 KiB  
Pathological Characterization and Risk Factors of Splenic Nodular Lesions in Dogs (Canis lupus familiaris)
by Gloria Corvera, Raúl Alegría-Morán, Federico Francisco Cifuentes and Cristian Gabriel Torres
Animals 2024, 14(5), 802; - 05 Mar 2024
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In dogs, the spleen is a secondary lymphoid organ that can be affected by both neoplastic and non-neoplastic nodules. In general, few studies relate histopathological diagnosis to tumor size and the number of nodules in spleen biopsies. Some of these studies are inconclusive [...] Read more.
In dogs, the spleen is a secondary lymphoid organ that can be affected by both neoplastic and non-neoplastic nodules. In general, few studies relate histopathological diagnosis to tumor size and the number of nodules in spleen biopsies. Some of these studies are inconclusive regarding the difference between neoplastic and non-neoplastic lesions and have small sample sizes or do not consider all splenic lesions. This study aimed to characterize splenic masses and determine risk factors for spleen tumors in dogs. A total of 507 histological reports corresponding to the diagnosis of splenic lesions in dogs from a private laboratory of animal pathology in the Metropolitan Region, Chile, were used. Data were analyzed by descriptive statistics and multiple logistic regression. The most frequent neoplastic and non-neoplastic diagnoses were hemangiosarcoma and hyperplasia, respectively. Most of the cases occurred in male (265 cases, 52.3%), senior (421 cases, 83%), and purebred individuals (342 cases, 67.5%). The most affected breeds were the Cocker Spaniel, German Shepherd, and Labrador Retriever. The most frequent lesion was a single nodule. The variables that exhibited a greater risk for the presentation of splenic neoplasia were male sex (odds ratio (OR) = 16.21; 95% confidence interval (CI) 1.741–150.879; p = 0.014), the presence of two or more splenic nodules (OR = 3.94; 95% CI 2.168–7.177; p < 0.001), an increase in nodule size greater than 2 cm (OR for quartiles 2, 3 and 4 of 2.2; 95% CI 1.036–4.941; p = 0.041, 2.9; 95% CI 1.331–6.576; p = 0.008, and 3.6; 95% CI 1.562–8.499; p = 0.003, respectively), and increasing age (OR = 1.23; 95% CI 1.048–1.436; p = 0.011). On the other hand, males exhibited a lower risk as age increases (OR = 0.76; 95% CI 0.615–0.928; p = 0.008). In conclusion, this study identified that males, multinodular presentation, nodule size, and age are risk factors for the occurrence of splenic neoplasia in dogs, knowledge that will contribute to the diagnostic management of dogs with spleen lesions. Full article
(This article belongs to the Special Issue Cancer in Animals: Surveillance and Risk Factors)
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