Reprint

Molecular Pathogenesis of Cardiac Arrhythmia

Edited by
November 2022
184 pages
  • ISBN978-3-0365-5614-7 (Hardback)
  • ISBN978-3-0365-5613-0 (PDF)

This book is a reprint of the Special Issue Molecular Pathogenesis of Cardiac Arrhythmia that was published in

Biology & Life Sciences
Medicine & Pharmacology
Summary

The heart is the first organ in an embryo, and its function is detected as a heartbeat. Thereafter, the heart continues to beat until the individual dies. Therefore, the beating rhythm is a robust system that must be maintained in a reliable manner. Arrhythmia appears as a breakdown of the biological system. This book contains a collection of papers that focus on the highly sophisticated molecular mechanisms of the heartbeat and arrhythmias caused by abnormalities in these molecular mechanisms. Membrane proteins such as ion channels and transporters are introduced, as well as review articles focusing on mitochondrial proteins and methods for identifying the responsible molecules based on mathematical analysis and high-throughput data analysis. The reader will be able to recognize both the miraculous mechanism of the heartbeat and the still incomplete danger of the heartbeat.

Format
  • Hardback
License
© by the authors
Keywords
cardiac potassium channel; hERG blocker; synthetic estrogen; QT intervals; drug interaction; mitochondria; heart; mitochondrial Na+-Ca2+ exchanger; NCLX; metabolism; Ca2+ signaling; pulmonary veins; cardiomyocytes; automatic activity; catecholamine; cardiac pacemaking; Na+-Ca2+ exchanger; pacemaker depolarization; sinus node; action potential; nonlinear dynamical system; bifurcation theory; afterdepolarizations; cardiac arrhythmias; hyperpolarization-activated cyclic-nucleotide gated channel; cyclic nucleotide binding domain; If; propofol; cAMP; adenylyl cyclase; supraventricular area; pulmonary vein; arrhythmia; atrial fibrillation; t-tubule; transcriptome; heart; SHOX2; atypically shaped cardiomyocytes; ACMs; subpopulation of cardiomyocytes; spontaneous beating; fetal cardiac gene proteins; cell fusion; ischemic resistance; cardiomyocyte; cardiac ventricle; heart; ryanodine receptor; catecholaminergic polymorphic ventricular tachycardia; calcium release deficiency syndrome; delayed afterdepolarizations; early afterdepolarizations; calcium sparks; long QT syndrome; arrhythmias; n/a