Reprint

In Vitro and In Vivo Models of Colorectal Cancer for Clinical Application

Edited by
July 2022
222 pages
  • ISBN978-3-0365-3966-9 (Hardback)
  • ISBN978-3-0365-3965-2 (PDF)

This book is a reprint of the Special Issue In Vitro and In Vivo Models of Colorectal Cancer for Clinical Application that was published in

Biology & Life Sciences
Medicine & Pharmacology
Summary

The Special Issue "In Vitro and In Vivo Models of Colorectal Cancer for Clinical Application", edited by Marta Baiocchi and Ann Zeuner for Cancers, collects original research papers and reviews, depicting the current state and the perspectives of CRC models for preclinical and translational research. Original research papers published in this issue focus on some of the hottest topics in CRC research, such as circulating tumor cells, epigenetic regulation of stemness states, new therapeutic targets, molecular CRC classification and experimental CRC models such as organoids and PDXs. Additionally, four reviews on CRC stem cells, immunotherapy and drug discovery provide an updated viewpoint on key topics linking benchtop to bedside research in CRC.

Format
  • Hardback
License
© 2022 by the authors; CC BY-NC-ND license
Keywords
colorectal cancer; organoids; 3D bioprinting; patient-derived xenograft; cancer-on-chip; drug combination; colorectal cancer; cancer stem cells; drug resistance; clinical trials; colorectal cancer; tumor-initiating cells; tumor heterogeneity; patient-derived cancer models; single-cell RNA-sequencing; tumor metabolism; transcriptional programs; tumor cell differentiation; colorectal cancer; immunotherapy; methods; colorectal cancer; chromosomal instability; DNA damage; targeted therapy; tumor-initiating cells; decitabine; colon cancer; DNA methylation; clinical translation study; machine learning; patient-derived tumor organoid; precision medicine; radiation response; rectal cancer; PDX model; CRC; mutation analysis; histological examination; cancer stem cells; colorectal cancer; animal models; in vitro culture; cancer stem cell methods; SATB2; colorectal carcinoma; prognosis; CDX2; circulating tumor cells; CTC cluster; colorectal cancer; size-based method; ScreenCell®; epithelial mesenchymal transition; hypoxia; HIF-1α; immunofluorescence analysis; sequential filtration