Reprint

Phospholipases: From Structure to Biological Function

Edited by
May 2022
348 pages
  • ISBN978-3-0365-4064-1 (Hardback)
  • ISBN978-3-0365-4063-4 (PDF)

This book is a reprint of the Special Issue Phospholipases: From Structure to Biological Function that was published in

Biology & Life Sciences
Medicine & Pharmacology
Summary

Phospholipases are a ubiquitous group of enzymes that hydrolyze ester bonds within membrane phospholipids. These enzymes serve multiple biological functions that go far beyond a mere membrane remodeling role in cellular homeostasis; they also play key functions in nutrient digestion and the regulated formation of bioactive lipids involved in cell signaling. It is to the latter function, critical to life, that this book is primarily concerned with. All the chapters are written by renowned experts in the area, and provide forefront information on the role phospholipases in a number of physiological and pathophysiological settings.

Format
  • Hardback
License
© 2022 by the authors; CC BY-NC-ND license
Keywords
inhibitor; metabolic stability; α-methylation; oxoesters; phospholipase A2; adrenic acid; arachidonic acid; mass spectrometry; lipid signaling; inflammation; phospholipase A2; monocytes/macrophages; crotoxin; snake venom; lung impairment; inflammatory response; lipid mediators; neuromuscular blocker; phospholipase A2; lipidomics; mass spectrometry; lipid signaling; inflammation; monocytes/macrophages; PAP-2; autotaxin; lysophosphatidate; G protein-coupled receptor; PLA2G6; fatty liver; phospholipid remodeling; diet-induced obesity; morbidly obesity; choline and methionine deficiency; glioblastoma; sphingolipid; sphingosine-1-phosphate; sphingomyelinase; sphingomyelin; metastasis; phosphatidic acid; diacylglycerol; lipin; signaling; cPLA2α; psoriasis; proliferation; anti-inflammatory; atherosclerosis; phospholipases; macrophages; T cells; lipins; pancreatic islets; β-cells; insulin secretion; glucose tolerance; insulin resistance; group VIA phospholipase A2; fatty acid; knockout mouse; lipid mediator; lipidomics; lysophospholipid; membrane; phospholipase A2; phospholipid; ceramide; sphingomyelin; acidic sphingomyelinase; neutral sphingomyelinase; hepatocellular carcinoma; alcoholic and nonalcoholic steatohepatitis; phospholipase A2; preadipocytes; prostaglandins; adipokines; cytokines; EP receptors; Group V phospholipase A2; macrophages; lipids; majeed syndrome; LPIN2; LIPIN2; chronic non-bacterial osteomyelitis; chronic recurrent multifocal osteomyelitis; autoinflammatory; inflammasome; macrophage; osteoclast; n/a