Reprint

Exploring the Multifaceted Roles of Glycosaminoglycans (GAGs) - New Advances and Further Challenges

Edited by
December 2021
334 pages
  • ISBN978-3-0365-2677-5 (Hardback)
  • ISBN978-3-0365-2676-8 (PDF)

This book is a reprint of the Special Issue Exploring the Multifaceted Roles of Glycosaminoglycans (GAGs) - New Advances and Further Challenges that was published in

Biology & Life Sciences
Medicine & Pharmacology
Summary

Glycosaminoglycans are linear, anionic polysaccharides (GAGs) consisting of repeating disaccharides. GAGs are ubiquitously localized throughout the extracellular matrix (ECM) and to the cell membranes of cells in all tissues. They are either conjugated to protein cores in the form of proteoglycans, e.g., chondroitin/dermatan sulfate (CS/DS), heparin/heparan sulfate (Hep/HS) and keratan sulfate (KS), as well as non-sulfated hyaluronan (HA). By modulating biological signaling GAGs participate in the regulation of homeostasis and also participate in disease progression. The book, entitled “Exploring the multifaceted roles of glycosaminoglycans (GAGs)—new advances and further challenges”, features original research and review articles. These articles cover several GAG-related timely topics in structural biology and imaging; morphogenesis, cancer, and other disease therapy and drug developments; tissue engineering; and metabolic engineering. This book also includes an article illustrating how metabolic engineering can be used to create the novel chondroitin-like polysaccharide.A prerequisite for communicating in any discipline and across disciplines is familiarity with the appropriate terminology. Several nomenclature rules exist in the field of biochemistry. The historical description of GAGs follows IUPAC and IUB nomenclature. New structural depictions such as the structural nomenclature for glycan and their translation into machine-readable formats have opened the route for cross-references with popular bioinformatics resources and further connections with other exciting “omics” fields.

Format
  • Hardback
License
© by the authors
Keywords
molecular dynamics; glycosaminoglycan; proteoglycan; chondroitin sulfate; carbohydrate conformation; carbohydrate flexibility; glycosidic linkage; ring pucker; force field; explicit solvent; malignant pleural mesothelioma; pleural effusion; Luminex; diagnostic biomarkers; malaria; heparin; mosquito; Plasmodium; Anopheles; ookinete; transmission blocking; antimalarial drugs; matrix metalloproteinases; glycosaminoglycans; small molecule inhibitors; drug discovery; aggrecan; tissue morphogenesis; HNK-1 trisaccharide; glycosaminoglycan; cellular regulation; extracellular matrix; DAC® HA-PLA copolymers; biopolymer degradation; polymer stability; DOSY NMR; hyaluronic acid; glycosaminoglycan; hydrogel; MRI; hydrodenticity; precision medicine; glycosaminoglycans; three-dimensional structure; database; polysaccharide conformation; protein-carbohydrate interactions; chondroitin; K4 chondroitin synthase; NDP-sugar misincorporation; glycosaminoglycans; tissue engineering; extracellular matrix; chondroitin sulfate; hyaluronic acid; dermatan sulfate; keratan sulfate; heparan sulfate; human articular cartilage; perlecan; heparan sulphate; heparanase; cartilage repair; natural repair; chondrocytes; biomarker; cancer; cancer therapy; extracellular vesicles; glycosaminoglycans; heparan sulfate; proteoglycans; hair follicle growth; glycosaminoglycans; infrared spectral imaging; k-means clustering; immunohistochemistry; chitosan; hyaluronic acid; lactose modified chitosan; NMR; molecular weight distribution; SEM; rheology; hyaluronidase; glycosaminoglycans; cancer; cancer therapy; hyaluronan; heparan sulfate; heparin; chondroitin sulfate; drug carriers; nanomaterial; therapy targets; heparan sulfate; inflammation; Syndecans; n/a