Reprint

Oligodendrocyte Physiology and Pathology Function

Edited by
January 2021
330 pages
  • ISBN978-3-03943-689-7 (Hardback)
  • ISBN978-3-03943-690-3 (PDF)

This book is a reprint of the Special Issue Oligodendrocyte Physiology and Pathology Function that was published in

Biology & Life Sciences
Medicine & Pharmacology
Summary
The adult vertebrate central nervous system mainly consists of neurons, astrocytes, microglia cells, and oligodendrocytes. Oligodendrocytes, the myelin-forming cells of the CNS, are subjected to cell stress and subsequent death in a number of metabolic or inflammatory disorders, among which multiple sclerosis (MS) is included. This disease is associated with the development of large demyelinated plaques, oligodendrocyte destruction, and axonal degeneration, paralleled by the activation of astrocytes and microglia as well as the recruitment of peripheral immune cells to the site of tissue injury. Of note, viable oligodendrocytes and an intact myelin sheath are indispensable for neuronal health. For example, it has been shown that oligodendrocytes provide nutritional support to neurons, fast axonal transport depends on proper oligodendrocyte function, and mice deficient in mature myelin proteins eventually display severe neurodegeneration. This Special Issue contains a collection of highly relevant primary research articles as well as review articles focusing on the development, physiology, and pathology of the oligodendrocyte–axon–myelin unit.
Format
  • Hardback
License
© 2020 by the authors; CC BY-NC-ND licence
Keywords
plasma membrane proteins; liquid chromatography-mass spectrometry; murine acute brain slices; reproducibility; rat cerebellum; Nsun5; Williams-Beuren syndrome (WBS); corpus callosum (CC); oligodendrocyte (OL); myelination; remyelination; EGFR inhibitor; smoothened agonist; microfibers; drug screening; multiple sclerosis; cuprizone; atrophy; design-based stereology; 18F-FDG; macromolecular proton fraction; MPF; myelin; magnetic resonance imaging; cuprizone model; demyelination; remyelination; oligodendrocyte precursors; oligodendrocytes; immunohistochemistry; oligodendrocyte; epigenetics; myelination; multiple sclerosis; remyelination; cuprizone; neurodegeneration; laquinimod; energy drinks; caffeine; taurine; neuron; oligodendrocytes; oligodendrocytes; OPC; oligodendrocyte progenitor cells; myelin; myelination; remyelination; multiple sclerosis; oligodendrocyte; myelin; remyelination; screening; nanofibers; multiple sclerosis; DigiGait™; experimental autoimmune encephalomyelitis; multiple sclerosis; gait analysis; schizophrenia; oligodendrocytes; myelin; interneuron; pluripotent stem cells; cognition; treatment; cre-recombinase; demyelination; experimental autoimmune encephalomyelitis (EAE); glial progenitor cells; myelin; tamoxifen; down syndrome; white matter; glial fate; transient receptor potential ankyrin 1; cuprizone; demyelination; astrocyte; conditional knockout; magnetic resonance imaging; astrocytes; oligodendrocytes; white matter disease; cross-talk; CNS; glial cells.; multiple sclerosis; cuprizone; age; oligodendrocyte; myelin; demyelination; remyelination; microglia; astrocyte; n/a