18 May 2023
Brain Sciences | Highly Cited Papers in 2021 in the Section “Molecular and Cellular Neuroscience”

The mission of the “Molecular and Cellular Neuroscience” Section is to publish cutting-edge original articles and critical reviews on the molecular and cellular basis of neurological disorders. In particular, the journal covers all aspects of molecular and cellular neuroscience, from genetic analyses of human populations to tissue culture and animal models of neurological disorders. Coverage includes experimental analyses of molecular and cellular events underpinning both developmental and adult plasticity mechanisms of the normal nervous system and occurring as a consequence of neurological dysfunction and in neuronal degeneration and repair.

As all of the articles published in our journal are of an open access format, you have free and unlimited access to the full text. We welcome you to read our most highly cited papers published in 2021 listed below:

1. “The Participation of Microglia in Neurogenesis: A Review”
by Diego R. Pérez-Rodríguez, Idoia Blanco-Luquin and Maite Mendioroz
Brain Sci. 2021, 11(5), 658; https://doi.org/10.3390/brainsci11050658
Available online: https://www.mdpi.com/2076-3425/11/5/658

2. “Delayed Onset Muscle Soreness (DOMS): The Repeated Bout Effect and Chemotherapy-Induced Axonopathy May Help Explain the Dying-Back Mechanism in Amyotrophic Lateral Sclerosis and Other Neurodegenerative Diseases”
by Balázs Sonkodi
Brain Sci. 2021, 11(1), 108; https://doi.org/10.3390/brainsci11010108
Available online: https://www.mdpi.com/2076-3425/11/1/108

3. “Sex Differences in Dopamine Receptors and Relevance to Neuropsychiatric Disorders”
by Olivia O. F. Williams, Madeleine Coppolino, Susan R. George and Melissa L. Perreault
Brain Sci. 2021, 11(9), 1199; https://doi.org/10.3390/brainsci11091199
Available online: https://www.mdpi.com/2076-3425/11/9/1199

4. “TREM2 Regulates High Glucose-Induced Microglial Inflammation via the NLRP3 Signaling Pathway”
by Yuan Li, Weihong Long, Menghan Gao, Fangtai Jiao, Zecai Chen, Mingyuan Liu and Lu Yu
Brain Sci. 2021, 11(7), 896; https://doi.org/10.3390/brainsci11070896
Available online: https://www.mdpi.com/2076-3425/11/7/896

5. “5-Aminoisoquinolinone, a PARP-1 Inhibitor, Ameliorates Immune Abnormalities through Upregulation of Anti-Inflammatory and Downregulation of Inflammatory Parameters in T Cells of BTBR Mouse Model of Autism”
by Khaled Alhosaini, Mushtaq A. Ansari, Ahmed Nadeem, Saleh A. Bakheet, Sabry M. Attia, Khalid Alhazzani, Thamer H. Albekairi, Haneen A. Al-Mazroua, Hafiz M. Mahmood and Sheikh F. Ahmad
Brain Sci. 2021, 11(2), 249; https://doi.org/10.3390/brainsci11020249
Available online: https://www.mdpi.com/2076-3425/11/2/249

6. “The Current Role of Dexmedetomidine as Neuroprotective Agent: An Updated Review”
by Zaara Liaquat, Xiaoying Xu, Prince Last Mudenda Zilundu, Rao Fu and Lihua Zhou
Brain Sci. 2021, 11(7), 846; https://doi.org/10.3390/brainsci11070846
Available online: https://www.mdpi.com/2076-3425/11/7/846

7. “Modelling Parkinson’s Disease: iPSCs towards Better Understanding of Human Pathology”
by Sahar Avazzadeh, Jara Maria Baena, Cameron Keighron, Yajaira Feller-Sanchez and Leo R. Quinlan
Brain Sci. 2021, 11(3), 373; https://doi.org/10.3390/brainsci11030373
Available online: https://www.mdpi.com/2076-3425/11/3/373

8. “Coenzyme a Biochemistry: From Neurodevelopment to Neurodegeneration”
by Luca Mignani, Barbara Gnutti, Daniela Zizioli and Dario Finazzi
Brain Sci. 2021, 11(8), 1031; https://doi.org/10.3390/brainsci11081031
Available online: https://www.mdpi.com/2076-3425/11/8/1031

9. “Role of Vitamin E and the Orexin System in Neuroprotection”
by Maria Ester La Torre, Ines Villano, Marcellino Monda, Antonietta Messina, Giuseppe Cibelli, Anna Valenzano, Daniela Pisanelli, Maria Antonietta Panaro, Nicola Tartaglia, Antonio Ambrosi et al.
Brain Sci. 2021, 11(8), 1098; https://doi.org/10.3390/brainsci11081098
Available online: https://www.mdpi.com/2076-3425/11/8/1098

10. “Virtual Reality (VR)-Based Environmental Enrichment in Older Adults with Mild Cognitive Impairment (MCI) and Mild Dementia”
by Waleed Riaz, Zain Yar Khan, Ali Jawaid and Suleman Shahid
Brain Sci. 2021, 11(8), 1103; https://doi.org/10.3390/brainsci11081103
Available online: https://www.mdpi.com/2076-3425/11/8/1103

11. “Exosomes as Emerging Biomarker Tools in Neurodegenerative and Neuropsychiatric Disorders—A Proteomics Perspective”
by Boby Mathew, M. Shahid Mansuri, Kenneth R. Williams and Angus C. Nairn
Brain Sci. 2021, 11(2), 258; https://doi.org/10.3390/brainsci11020258
Available online: https://www.mdpi.com/2076-3425/11/2/258

12. “Oxidative Stress and Neurodevelopmental Outcomes in Rat Offspring with Intrauterine Growth Restriction Induced by Reduced Uterine Perfusion”
by Marcelo E. Rains, Colin B. Muncie, Yi Pang, Lir-Wan Fan, Lu-Tai Tien and Norma B. Ojeda
Brain Sci. 2021, 11(1), 78; https://doi.org/10.3390/brainsci11010078
Available online: https://www.mdpi.com/2076-3425/11/1/78

13. “CSF Secretion Is Not Altered by NKCC1 Nor TRPV4 Antagonism in Healthy Rats”
by Steven W. Bothwell, Daniel Omileke, Adjanie Patabendige and Neil J. Spratt
Brain Sci. 2021, 11(9), 1117; https://doi.org/10.3390/brainsci11091117
Available online: https://www.mdpi.com/2076-3425/11/9/1117

14. “Prominent and Regressive Brain Developmental Disorders Associated with Nance-Horan Syndrome”
by Celeste Casto, Valeria Dipasquale, Ida Ceravolo, Antonella Gambadauro, Emanuela Aliberto, Karol Galletta, Francesca Granata, Giorgia Ceravolo, Emanuela Falzia, Antonella Riva et al.
Brain Sci. 2021, 11(9), 1150; https://doi.org/10.3390/brainsci11091150
Available online: https://www.mdpi.com/2076-3425/11/9/1150

15. “Searching the Dark Genome for Alzheimer’s Disease Risk Variants”
by Rachel Raybould and Rebecca Sims
Brain Sci. 2021, 11(3), 332; https://doi.org/10.3390/brainsci11030332
Available online: https://www.mdpi.com/2076-3425/11/3/332

16. “Against the Resilience of High-Grade Gliomas: The Immunotherapeutic Approach (Part I)”
by Alice Giotta Lucifero and Sabino Luzzi
Brain Sci. 2021, 11(3), 386; https://doi.org/10.3390/brainsci11030386
Available online: https://www.mdpi.com/2076-3425/11/3/386

17. “Against the Resilience of High-Grade Gliomas: Gene Therapies (Part II)”
by Alice Giotta Lucifero and Sabino Luzzi
Brain Sci. 2021, 11(8), 976; https://doi.org/10.3390/brainsci11080976
Available online: https://www.mdpi.com/2076-3425/11/8/976

18. “Development and Validation of a Long-Term 3D Glioblastoma Cell Culture in Alginate Microfibers as a Novel Bio-Mimicking Model System for Preclinical Drug Testing”
by Miodrag Dragoj, Jasmina Stojkovska, Tijana Stanković, Jelena Dinić, Ana Podolski-Renić, Bojana Obradović and Milica Pešić
Brain Sci. 2021, 11(8), 1025; https://doi.org/10.3390/brainsci11081025
Available online: https://www.mdpi.com/2076-3425/11/8/1025

19. “Shared Genetic Background between Parkinson’s Disease and Schizophrenia: A Two-Sample Mendelian Randomization Study”
by Kiwon Kim, Soyeon Kim, Woojae Myung, Injeong Shim, Hyewon Lee, Beomsu Kim, Sung Kweon Cho, Joohyun Yoon, Doh Kwan Kim and Hong-Hee Won
Brain Sci. 2021, 11(8), 1042; https://doi.org/10.3390/brainsci11081042
Available online: https://www.mdpi.com/2076-3425/11/8/1042

20. “Neuroprotective Potential of Mild Uncoupling in Mitochondria. Pros and Cons”
by Dmitry B. Zorov, Nadezda V. Andrianova, Valentina A. Babenko, Irina B. Pevzner, Vasily A. Popkov, Savva D. Zorov, Ljubava D. Zorova, Egor Yu. Plotnikov, Gennady T. Sukhikh and Denis N. Silachev
Brain Sci. 2021, 11(8), 1050; https://doi.org/10.3390/brainsci11081050
Available online: https://www.mdpi.com/2076-3425/11/8/105

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