Venereology

2 pages, 198 KiB

Open AccessEditorial

The Emerging Threat of Antimicrobial-Resistant Sexually Transmitted Infections: Epidemiology, Management and Detection

by Karan Varshney

Venereology 2023, 2(2), 76-77; https://doi.org/10.3390/venereology2020007 - 19 May 2023

Cited by 1 | Viewed by 1170

Antimicrobial resistance (AMR) has become one of the most pressing public health crises, with sexually transmitted infections (STIs) of all types rapidly becoming resistant to treatments [...] Full article

(This article belongs to the Special Issue Antimicrobial Resistant Sexually Transmitted Infections: Epidemiology, Detection, and Management)

11 pages, 845 KiB

Open AccessReview

Secondary Syphilis: Pathophysiology, Clinical Manifestations, and Diagnostic Testing

by Shahrukh Chaudhry, Idris Akinlusi, Ted Shi and Jorge Cervantes

Venereology 2023, 2(2), 65-75; https://doi.org/10.3390/venereology2020006 - 11 Apr 2023

Cited by 1 | Viewed by 5960

Abstract

The subspecies T. pallidum pallidum is the cause of the most infamous sexually and congenitally transmitted disease, syphilis. This disease has an estimated incidence of six million infections every year. Multiple studies have noted that the prevalence of syphilis has been steadily increasing worldwide in recent decades, especially among MSMs and HIV-positive patients. Clinically, syphilis presents in four stages with multiple different clinical manifestations. In this paper, we examine the current literature to determine the history and progression, pathogenesis, clinical features, and testing of secondary syphilis. Secondary syphilis is a stage of the disease with the most exuberant local and systemic clinical manifestations. The basis of the pathogenesis of SS underscores the unique mechanisms by which Treponema pallidum utilizes to escape immune recognition while simultaneously induces inflammation. SS can affect multiple organ systems and become more than just an STD. The most common presentation of secondary syphilis is rash, which manifests as a copper-colored maculopapular lesion on the trunk, palms, and soles. Although the RPR, VDRL, and FTA-ABS tests are perhaps the most commonly used diagnostic tools for syphilis and make up the traditional and reverse algorithms, there are other methods, including morphology and immunohistochemistry. Full article

► Show Figures

Figure 1

6 pages, 2301 KiB

Open AccessBrief Report

Current Trends in Syphilis Mortality in the United States, 2015–2020

by Noel C. Barragan, Ranjana N. Wickramasekaran, Frank Sorvillo, Lisa V. Smith and Tony Kuo

Venereology 2023, 2(2), 59-64; https://doi.org/10.3390/venereology2020005 - 29 Mar 2023

Viewed by 4297

Abstract

Rates of reported cases of syphilis have steadily increased since 2000 in the United States. However, despite the increase in cases, mortality from 2000–2014 declined. The following study examines the latest trends in syphilis-related deaths using 2015–2020 Multiple Cause of Death data. A total of 925 syphilis-related deaths were identified during the study period, 30% of which listed syphilis as the underlying cause of death. On average, age-adjusted syphilis mortality increased by 9.51% annually (95% CI = 5.41%–13.77%). Study findings indicate a marked increase in deaths attributed to syphilis, underscoring the need to more systematically and comprehensively address the growing sexually transmitted infection epidemic in the United States. Full article

► Show Figures

Figure 1

Journal Menu

Journal Browser

Venereology, Volume 2, Issue 2 (June 2023) – 3 articles

Further Information

Guidelines

MDPI Initiatives

Follow MDPI