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Physiologia, Volume 2, Issue 2 (June 2022) – 2 articles

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12 pages, 1803 KiB  
Review
From Innate Immunity to Inflammation: A Primer on Multiple Facets of NF-κB Signaling in COVID-19
Physiologia 2022, 2(2), 34-45; https://doi.org/10.3390/physiologia2020004 - 17 Jun 2022
Cited by 2 | Viewed by 1996
Abstract
Nuclear factor-kappa B (NF-κB) induces the expression of many pro-inflammatory genes, including cytokines and chemokines. In the past decades, a wealth of clinical as well as animal model-based studies have demonstrated the association of the deregulated NF-κB signaling pathway with the progression of [...] Read more.
Nuclear factor-kappa B (NF-κB) induces the expression of many pro-inflammatory genes, including cytokines and chemokines. In the past decades, a wealth of clinical as well as animal model-based studies have demonstrated the association of the deregulated NF-κB signaling pathway with the progression of various inflammatory diseases, including inflammatory bowel disease (IBD), multiple sclerosis (MS), and chronic obstructive pulmonary disease (COPD). Given the conserved role of the NF-κB pathway as the pivotal regulator of pro-inflammatory gene expression, different components of the NF-κB pathway are proposed as major therapeutic targets against these diseases. The ongoing coronavirus disease of 2019 (COVID-19) has posed a significant public health crisis regarding inflammation-related diseases. A robust inflammatory response is associated with COVID-19-infection-related complications, including muti-organ failure and death. This review summarizes the past and current state of knowledge on the role of the NF-κB signaling pathway in the innate immune response and inflammatory diseases with the objective of potential therapeutic use in developing effective treatment options for COVID-19. Full article
(This article belongs to the Special Issue Feature Papers in Human Physiology)
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2 pages, 179 KiB  
Editorial
A Note from the Editor-in-Chief of Physiologia
Physiologia 2022, 2(2), 32-33; https://doi.org/10.3390/physiologia2020003 - 02 Jun 2022
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Abstract
I am proud to call myself a physiologist, and, as such, it was my pleasure and honour (over a year ago now) to take on the role of founding Editor-in-Chief of Physiologia [...] Full article
(This article belongs to the Special Issue Feature Papers in Human Physiology)
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