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Proceeding Paper

Occupational and Environmental Chemical Risk Assessment in a Changing Climate: A Critical Analysis of the Current Discourse and Future Perspectives †

1
Toxicology and Biochemistry, National Institute for Occupational Health, National Health Laboratory Service, Johannesburg 2000, South Africa
2
Department of Environmental Health, University of Johannesburg, Johannesburg 2000, South Africa
3
Environmental Health Division, School of Public Health and Family Medicine, University of Cape Town, Cape Town 7925, South Africa
4
School of Health Systems & Public Health, University of Pretoria, Hatfield 0028, South Africa
*
Author to whom correspondence should be addressed.
Presented at the 4th International Electronic Conference on Environmental Research and Public Health—Climate Change and Health in a Broad Perspective, 15–30 October 2022; Available online: https://ecerph-4.sciforum.net/.
Environ. Sci. Proc. 2022, 24(1), 2; https://doi.org/10.3390/ECERPH-4-13105
Published: 26 October 2022

Abstract

:
Global climate change (GCC) models predict direct changes in region-specific rainfall patterns, floods, sea levels, infectious and heat-related disease patterns. The indirect effects of GCC on chemical risk assessment (CRA) have not received adequate attention. This study presents a synopsis of the implications of GCC on CRA, which forms the basis for both occupational and environmental health. GCC can make organisms more sensitive to chemical stressors, and chemical exposures can make organisms more sensitive to GCC. Consequently, occupational and environmental chemical RA will need mechanistic understanding and analytical tools to predict outcomes of multiple stressors and their combined effects.

1. Introduction

Expanding human activities increase the variety and intensity of stressors, whose effects are exacerbated by accelerating climate change [1,2,3,4,5]. For example, the increase in the concentration of greenhouse gases (GHGs) such as carbon dioxide, methane and dinitrogen oxide is resulting in global warming and climate change [6].
Global climate change (GCC) can make organisms more sensitive to chemical stressors, and chemical exposures can make organisms more sensitive to GCC. Since stressors are heterogeneous and can affect individuals, populations, communities, and their habitats, many disciplines investigate their combined effects, e.g., pharmacology and epidemiology, toxicology, environmental science, conservation biology, and ecology [1]. The common challenge, irrespective of the discipline, is that combined effects cannot be predicted reliably from the individual effect of each stressor, where the way in which each stressor operates in isolation may change or be modified in the presence of other stressors [1,7,8,9].
This study presents a synopsis of implications of climate change on occupational and environmental chemical risk assessment (CRA). After analysing all the pertinent issues on the topic, the study also makes suggestions for incorporating climate change into occupational and environmental CRA of chemicals.

2. Direct Effects of Climate Change

GCC may influence a variety of environmental variables, including temperature, precipitation, salinity, pH, and insolation of ultraviolet (UV) radiation. Overall, climate change is expected to result in more frequent and intense heat waves, precipitation and storm events. These changes are expected to have an impact on the behaviour and fate of pollutants as well as changes in interactions of pollutants with living organisms, especially thresholds that might trigger adverse events.

2.1. Temperature

Differences in temperatures may alter the physicochemical properties, bioavailability and toxicokinetics of chemicals resulting in different toxicity profiles. Biological rates depend on temperature, where physiological dose–response functions can be used to represent variation (of biological rates) in response to environmental stressors [10]. For example, juvenile Penaeus semisulcatus were reported to exhibit significantly higher toxicity to ammonia at 14 °C than at 26 °C [11]. Similarly, the toxicities of two commonly used biocides, chlorothalonil and copper pyrithione (CuPT), to marine copepod Tigriopus japonicus and dinoflagellate Pyrocystis lunulaf, were highly temperature-dependent, although the temperature dependency varied between the two chemicals [12]. Kwok and Leung [13] also reported temperature-dependent toxicities for tributyltin chloride antifouling biocides to T japonicas, while Li et al. [14] reported temperature-dependent toxicities of copper sulphate pentahydrate triphenyltin chloride, dichlorophenyltrichloroethane and copper pyrithione (to marine medaka fish Oryzias melastigma and the copepod T japonicus).
Temperature has also been shown to affect the toxicity of pollutants to terrestrial organisms. For example, the effect of temperature on the reproductive toxicity of mercury affecting swallows [15] and the effects of temperature on the toxicity of many pollutants affecting herbivores [16] has been reported. Most notably, for several different chemicals, a difference in ambient of 10 °C from 26 to 36 °C produced an effect in rodents that was similar to increasing the dose two- to eight-fold, while the lethal dose of caffeine in mice at 36 °C is one-fifth the lethal dose for mice at 26 or 8 °C [16].
Changes in temperature have an effect on the bioavailability of persistent organic pollutants and their subsequent uptake and bioaccumulation. For example, increased temperatures are expected to reduce the overall bioaccumulation of organic contaminants in the Arctic marine food web [17], but increase the bioavailability of metals (Cd, Pb and Zn) in soil [18].

2.2. Preciptation, Rainfall Patterns, Floods, Sea Levels

GCC will influence water availability and quality. Increased precipitation has been predicted for some regions such as northern Europe, North and South America as well as northern and central Asia, while substantial droughts have been predicted for other regions such as southern Africa, Asia and the Mediterranean, i.e., the impacts are area- or region-specific [19]. Although the mean total quantity of water resources is likely to increase for Africa as a whole, substantial variations are expected for individual sub-basins and countries, along with increases in the drought events and their duration, i.e., variations exist for regions and sub-regions [20]. In that regard, IPCC models predict rainfall increases over most part of West Africa with the exception of the coastline where a little decrease in amount of rainfall was estimated [21]. This stressor does not necessarily act in isolation, where the effects of precipitation and temperature on vegetation index have also been modelled and should be considered [22].

2.3. Water and Soil Salinity

The effects of climate change on water availability and quality will in turn affect water and soil salinity [23,24]. Salinity has been reported to enhance the toxicity of many pollutants to many aquatic organisms, including L-selenomethionine to Japanese medaka (Oryzias latipes) embryos [25], polyvinylpyrrolidone (PVP) coated silver nanoparticles to Tisbe battagliai (Tb) and Ceramium tenuicorne (Ct) [26]. Interaction between salinity and pollutants has been reported not only in aquatic organisms, but also terrestrial organisms. For example, salinity increased the toxicity, as indicated in changes in weight and mortality, of Zn2+ to the earthworm Eisenia fetida [27]. Salinity also increased soil Cd availability and toxicity to microbial organisms, as indicated in the decreased soil microbial respiration rate, microbial biomass and enzyme activity [28]. Similarly, salinity reduced tolerance of conocarpus (Conocarpus erectus L.) against Cd stress due to increased uptake of toxic ions and intensification of oxidative stress [29]. In some cases, increasing salinity reduced the toxicity of some pollutants. For example, increased salinity reduced the acute toxicity to T japonicus due to precipitation of the dissolved concentrations of the ions [30]. Similarly, salinity was reported to be protective against acute Ni toxicity in the crustacean species Litopenaeus vannamei and Excirolana armata [31].

3. Indirect Effects of Climate Change

The impacts of GCC are numerous, including changes in human migration as a result of rainfall patterns or sea level rise, heat-related mortality and mutation in infectious disease vectors [32]. Furthermore, predictive models indicate that GCC will affect the geographic distribution and annual number of generations of agricultural pests, which will in turn change pesticide use patterns [33,34,35]. This will increase the usage and sources of pesticides [36,37,38].
Following release from primary sources, pollutants are stored on various compartments from where they are subject to various secondary release processes. According to UNEP/AMAP [39], climate change will affect the rate of mobilization from materials and stockpiles, volatilization as well as partitioning between air and soil and air and water. Indeed, changes in climate variables such as temperature, winds, precipitation, currents, and snow will in turn change transport, deposition and fate of contaminants. Soil properties that control pollutants adsorption and mobility such as temperature, moisture, organic matter, mineral fractions, and microbial activities are affected by climate change. Consequently, exposure to contaminants could be increased because of desorption and remobilization of soil contaminants [40]. This is important for both environmental exposure to chemicals (e.g., pesticides) and occupational exposure to chemicals, especially exposure of workers to agricultural pesticides on re-entry.

4. Influence on (Toxic) Action or Interactions between Chemicals and Target Molecules

GCC can influence physiochemical properties of chemicals (toxicokinetics), i.e., absorption, distribution, metabolism, and excretion (ADME), or mode of action or interactions between chemicals and target molecules (toxicodymanics), e.g., various transport, degradation, dissipation and fate processes which can in turn influence the internal dose. Chemical, biological and ecological information is used to define the pathways that link stressor exposure to potential adverse outcomes at different organisational levels [41], e.g., adverse outcome pathways (AOPs) in ecotoxicology [42]. AOPs have been used to predict that toxicants may alter the ability of organisms to respond to climate change and, in turn, climate stressors may affect chemical toxicity [43]. AOPs depict links starting from a mechanism-based molecular initiating event (MIE), followed by biological key events (KE) that are connected via key event relationships (KER) and result in an adverse outcome (AO). Chemical and climate-specific stressors can influence the MIE, KE, or KER and ultimately change the AO.

5. Implications on the Validity of Occupational and Environmental Chemical Risk Assessment

GCC may cause more frequent and intense heat waves, precipitation and storm events where these changes impact on the behaviour and fate of pollutants, interactions of pollutants with living organisms, and thresholds that trigger adverse events. The impacts of climate change on the transport, fate and exposure to pollutants have been thoroughly examined and discussed [19,40,44,45,46,47,48,49,50]. Occupational and environmental CRA requires an understanding of these kinds of relationships between exposure and effects.
The exposure to chemicals in occupational and environmental settings depends on the dissipation, fate and behaviour of the chemical, which are in turn affected by a number of physical, biological, and ecological processes in the environment that include microbial degradation, volatilization, adsorption, uptake by plants and animals, surface runoff, and leaching [51,52]. These processes are interrelated, where the governing factors for each of these processes are complicated. Hence, it is difficult to interrogate each process in isolation.
The dependencies of toxicity of many pollutants on temperature and salinity are crucial for toxicology and RA. It is predicted that anthropogenically-driven GCC may increase salinity and incidents of extreme temperature events, which may have significant effects on the toxicity of chemical pollutants and lead to adverse effects [43]. Occupational and environmental CRA are based on toxicity data on model organisms obtained under standard test conditions, which may not reflect actual environmental conditions that may change how organisms respond to chemical insults. Indeed, after exposing larval and adult grass shrimp to the fungicide chlorothalonil and the insecticide Scourge under various test conditions of (i) standard toxicity test conditions, (ii) a 10 °C increase in temperature, (iii) a 10 ppt increase in salinity, and (iv) a combined increased temperature and salinity exposure, DeLorenzo et al. [53] reported that standard toxicity bioassays may not be predictive of actual pesticide toxicity under variable environmental conditions.
For ecological CRA, Landis et al. [54] proposed critical changes that involve use of conceptual cause–effect diagrams that include both direct and indirect effects of climate change. In order to consider effects of climate change in standard toxicity testing of pollutants, DeLorenzo et al. [53] recommended toxicity testing under a wider range of exposure conditions to improve the accuracy of CRA.
GCC will trigger multiple stressors and impact a myriad of contaminants in different ways. Under these circumstances, CRA, which often assesses effects of one stressor at time, will have to concomitantly consider interactions among contaminant and non-contaminant stressors. This will include new temperature and precipitation regimes, new ecosystems and hydrologic processes that are likely to result in new responses to lethal and sub-lethal doses of pollutants [54]. Hooper et al. [43] proposed the use of mechanistic toxicological tools such as AOPs in assessing climate change risks.

6. Conclusions

Rapid modifications occur in the environment resulting from climate change and encroachment of human activities on all ecosystems. However, some stressors cannot be mitigated rapidly. GCC will have implications on the validity of occupational and environmental CRA through space and time. Consequently, occupational and environmental CRA will need mechanistic understanding and analytical tools to predict outcomes of multiple stressors and their combined effects. For example, conceptual cause–effect diagrams at spatial and temporal scales can be used in order to account for both direct and indirect effects of climate change, whose magnitude will depend on the extent to which current conditions are altered.

Author Contributions

The individual contributions are: Conceptualization, W.U.; methodology, W.U.; writing—original draft preparation, W.U. and N.M.S.; writing—review and editing, W.U. and N.M.S.; supervision, N.M.S.; project administration, W.U. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Institutional Review Board Statement

Not applicable.

Informed Consent Statement

Not applicable.

Data Availability Statement

Not applicable.

Conflicts of Interest

The authors declare no conflict of interest.

References

  1. Pirotta, E.; Thomas, L.; Costa, D.P.; Hall, A.J.; Harris, C.M.; Harwood, J.; Kraus, S.D.; Miller, P.J.O.; Moore, M.J.; Photopoulou, T.; et al. Understanding the combined effects of multiple stressors: A new perspective on a longstanding challenge. Sci. Total Environ. 2022, 821, 153322. [Google Scholar] [CrossRef]
  2. Gissi, E.; Manea, E.; Mazaris, A.D.; Fraschetti, S.; Almpanidou, V.; Bevilacqua, S.; Coll, M.; Guarnieri, G.; Lloret-Lloret, E.; Pascual, M. A review of the combined effects of climate change and other local human stressors on the marine environment. Sci. Total Environ. 2021, 755, 142564. [Google Scholar] [CrossRef]
  3. He, Q.; Silliman, B.R. Climate change, human impacts, and coastal ecosystems in the Anthropocene. Curr. Biol. 2019, 29, R1021–R1035. [Google Scholar] [CrossRef] [PubMed]
  4. Li, P.; Peng, C.; Wang, M.; Luo, Y.; Li, M.; Zhang, K.; Zhang, D.; Zhu, Q. Dynamics of vegetation autumn phenology and its response to multiple environmental factors from 1982 to 2012 on Qinghai-Tibetan Plateau in China. Sci. Total Environ. 2018, 637, 855–864. [Google Scholar] [CrossRef]
  5. Brown, C.J.; Saunders, M.I.; Possingham, H.P.; Richardson, A.J. Managing for interactions between local and global stressors of ecosystems. PLoS ONE 2013, 8, e65765. [Google Scholar] [CrossRef] [PubMed]
  6. Schneider, S.H.; Lane, J. An overview of ‘dangerous’ climate change. In Avoiding Dangerous. Climate Change; Schellnhuber, H.J., Cramer, W., Nakicenovic, N., Wigley, T., Yohe, G., Eds.; Cambridge University Press: Cambridge, UK, 2006; pp. 7–24. [Google Scholar]
  7. Piggott, J.J.; Niyogi, D.K.; Townsend, C.R.; Matthaei, C.D. Multiple stressors and stream ecosystem functioning: Climate warming and agricultural stressors interact to affect processing of organic matter. J. Appl. Ecol. 2015, 52, 1126–1134. [Google Scholar] [CrossRef]
  8. Orr, J.A.; Vinebrooke, R.D.; Jackson, M.C.; Kroeker, K.J.; Kordas, R.L.; Mantyka-Pringle, C.; Van den Brink, P.J.; De Laender, F.; Stoks, R.; Holmstrup, M. Towards a unified study of multiple stressors: Divisions and common goals across research disciplines. Proc. R. Soc. B 2020, 287, 20200421. [Google Scholar] [CrossRef]
  9. Folt, C.; Chen, C.; Moore, M.; Burnaford, J. Synergism and antagonism among multiple stressors. Limnol. Oceanogr. 1999, 44 Pt 2, 864–877. [Google Scholar] [CrossRef] [Green Version]
  10. Angilletta, M.J., Jr.; Angilletta, M.J. Thermal Adaptation: A Theoretical and Empirical Synthesis; Oxford University Press: Oxford, UK, 2009. [Google Scholar]
  11. Kır, M.; Kumlu, M.; Eroldoğan, O.T. Effects of temperature on acute toxicity of ammonia to Penaeus semisulcatus juveniles. Aquaculture 2004, 241, 479–489. [Google Scholar] [CrossRef]
  12. Bao, V.; Koutsaftis, A.; Leung, K. Temperature-dependent toxicities of chlorothalonil and copper Pyrithione to the marine copepod tigriopus japonicus and dinoflagellate Pyrocystis lunula. Australas. J. Ecotoxicol. 2008, 14, 45–54. [Google Scholar]
  13. Kwok, K.; Leung, K. Toxicity of antifouling biocides to the intertidal harpacticoid copepod Tigriopus japonicus (Crustacea, Copepoda): Effects of temperature and salinity. Mar. Pollut. Bull. 2005, 51, 830–837. [Google Scholar] [CrossRef] [PubMed]
  14. Li, A.J.; Leung, P.T.; Bao, V.W.; Yi, A.X.; Leung, K.M. Temperature-dependent toxicities of four common chemical pollutants to the marine medaka fish, copepod and rotifer. Ecotoxicology 2014, 23, 1564–1573. [Google Scholar] [CrossRef] [PubMed]
  15. Hallinger, K.K.; Cristol, D.A. The role of weather in mediating the effect of mercury exposure on reproductive success in tree swallows. Ecotoxicology 2011, 20, 1368–1377. [Google Scholar] [CrossRef]
  16. Dearing, M.D. Temperature-dependent toxicity in mammals with implications for herbivores: A review. J. Comp. Physiol. B 2013, 183, 43–50. [Google Scholar] [CrossRef] [PubMed]
  17. Borgå, K.; Saloranta, T.M.; Ruus, A. Simulating climate change-induced alterations in bioaccumulation of organic contaminants in an Arctic marine food web. Environ. Toxicol. Chem. 2010, 29, 1349–1357. [Google Scholar] [CrossRef] [PubMed]
  18. González-Alcaraz, M.N.; van Gestel, C.A.M. Climate change effects on enchytraeid performance in metal-polluted soils explained from changes in metal bioavailability and bioaccumulation. Environ. Res. 2015, 142, 177–184. [Google Scholar] [CrossRef]
  19. Noyes, P.D.; McElwee, M.K.; Miller, H.D.; Clark, B.W.; Van Tiem, L.A.; Walcott, K.C.; Erwin, K.N.; Levin, E.D. The toxicology of climate change: Environmental contaminants in a warming world. Environ. Int. 2009, 35, 971–986. [Google Scholar] [CrossRef]
  20. Faramarzi, M.; Abbaspour, K.C.; Ashraf Vaghefi, S.; Farzaneh, M.R.; Zehnder, A.J.B.; Srinivasan, R.; Yang, H. Modeling impacts of climate change on freshwater availability in Africa. J. Hydrol. 2013, 480, 85–101. [Google Scholar] [CrossRef]
  21. Adefisan, E. Climate change impact on rainfall and temperature distributions over West Africa from three IPCC scenarios. J. Earth Sci. Clim. Chang. 2018, 9, 476. [Google Scholar]
  22. Larsen, S.; Andersen, T.; Hessen, D.O. Climate change predicted to cause severe increase of organic carbon in lakes. Glob. Chang. Biol. 2011, 17, 1186–1192. [Google Scholar] [CrossRef]
  23. Little, S.; Wood, P.J.; Elliott, M. Quantifying salinity-induced changes on estuarine benthic fauna: The potential implications of climate change. Estuar. Coast. Shelf Sci. 2017, 198, 610–625. [Google Scholar] [CrossRef] [Green Version]
  24. Tomaz, A.; Palma, P.; Alvarenga, P.; Gonçalves, M.C. Chapter 13—Soil salinity risk in a climate change scenario and its effect on crop yield. In Climate Change and Soil Interactions; Prasad, M.N.V., Pietrzykowski, M., Eds.; Elsevier: Amsterdam, The Netherlands, 2020; pp. 351–396. [Google Scholar]
  25. Lavado, R.; Shi, D.; Schlenk, D. Effects of salinity on the toxicity and biotransformation of l-selenomethionine in Japanese medaka (Oryzias latipes) embryos: Mechanisms of oxidative stress. Aquat. Toxicol. 2012, 108, 18–22. [Google Scholar] [CrossRef] [PubMed]
  26. Macken, A.; Byrne, H.J.; Thomas, K.V. Effects of salinity on the toxicity of ionic silver and Ag-PVP nanoparticles to Tisbe battagliai and Ceramium tenuicorne. Ecotoxicol. Environ. Saf. 2012, 86, 101–110. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  27. Owojori, O.J.; Reinecke, A.J.; Rozanov, A.B. Effects of salinity on partitioning, uptake and toxicity of zinc in the earthworm Eisenia fetida. Soil Biol. Biochem. 2008, 40, 2385–2393. [Google Scholar] [CrossRef]
  28. Raiesi, F.; Sadeghi, E. Interactive effect of salinity and cadmium toxicity on soil microbial properties and enzyme activities. Ecotoxicol. Environ. Saf. 2019, 168, 221–229. [Google Scholar] [CrossRef] [PubMed]
  29. Rehman, S.; Abbas, G.; Shahid, M.; Saqib, M.; Umer Farooq, A.B.; Hussain, M.; Murtaza, B.; Amjad, M.; Naeem, M.A.; Farooq, A. Effect of salinity on cadmium tolerance, ionic homeostasis and oxidative stress responses in conocarpus exposed to cadmium stress: Implications for phytoremediation. Ecotoxicol. Environ. Saf. 2019, 171, 146–153. [Google Scholar] [CrossRef]
  30. Park, J.; Kim, S.; Yoo, J.; Lee, J.-S.; Park, J.-W.; Jung, J. Effect of salinity on acute copper and zinc toxicity to Tigriopus japonicus: The difference between metal ions and nanoparticles. Mar. Pollut. Bull. 2014, 85, 526–531. [Google Scholar] [CrossRef]
  31. Leonard, E.M.; Barcarolli, I.; Silva, K.R.; Wasielesky, W.; Wood, C.M.; Bianchini, A. The effects of salinity on acute and chronic nickel toxicity and bioaccumulation in two euryhaline crustaceans: Litopenaeus vannamei and Excirolana armata. Comp. Biochem. Physiol. Part C: Toxicol. Pharmacol. 2011, 154, 409–419. [Google Scholar] [CrossRef] [Green Version]
  32. IPCC. Summary for Policymakers. In Global Warming of 1.5 °C; IPCC: Geneva, Switzerland, 2018. [Google Scholar]
  33. Jo, W.S.; Kim, H.-Y.; Kim, B.J. Climate change alters diffusion of forest pest: A model study. J. Korean Phys. Soc. 2017, 70, 108–115. [Google Scholar] [CrossRef] [Green Version]
  34. Kocmankova, E.; Trnka, M.; Eitzinger, J.; Dubrovský, M.; Štěpánek, P.; Semeradova, D.; Balek, J.; Skalak, P.; Farda, A.; Juroch, J.; et al. Estimating the impact of climate change on the occurrence of selected pests at a high spatial resolution: A novel approach. J. Agric. Sci. 2011, 149, 185–195. [Google Scholar] [CrossRef]
  35. Willis, J.C.; Bohan, D.A.; Choi, Y.H.; Conrad, K.F.; Semenov, M.A. Use of an individual-based model to forecast the effect of climate change on the dynamics, abundance and geographical range of the pest slug Deroceras reticulatum in the UK. Glob. Chang. Biol. 2006, 12, 1643–1657. [Google Scholar] [CrossRef]
  36. Koleva, N.G.; Schneider, U.A.; Tol, R.S. The Impact of Weather Variability and Climate Change on Pesticide Applications in the US—An Empirical Investigation. Int. J. Ecol. Econ. Stat. 2009, 18, 64–81. [Google Scholar]
  37. Skendžić, S.; Zovko, M.; Živković, I.P.; Lešić, V.; Lemić, D. The Impact of Climate Change on Agricultural Insect Pests. Insects 2021, 12, 440. [Google Scholar] [CrossRef] [PubMed]
  38. Zeng, J.; Liu, Y.; Zhang, H.; Liu, J.; Jiang, Y.; Wyckhuys, K.A.G.; Wu, K. Global warming modifies long-distance migration of an agricultural insect pest. J. Pest Sci. 2020, 93, 569–581. [Google Scholar] [CrossRef]
  39. UNEP/AMAP Limate Change and POPs: Predicting the Impacts. Available online: https://www.amap.no/documents/download/3237/inline (accessed on 30 August 2022).
  40. Biswas, B.; Qi, F.; Biswas, J.K.; Wijayawardena, A.; Khan, M.A.I.; Naidu, R. The fate of chemical pollutants with soil properties and processes in the climate change paradigm—A review. Soil Syst. 2018, 2, 51. [Google Scholar] [CrossRef] [Green Version]
  41. Simmons, B.I.; Blyth, P.S.; Blanchard, J.L.; Clegg, T.; Delmas, E.; Garnier, A.; Griffiths, C.A.; Jacob, U.; Pennekamp, F.; Petchey, O.L. Refocusing multiple stressor research around the targets and scales of ecological impacts. Nat. Ecol. Evol. 2021, 5, 1478–1489. [Google Scholar] [CrossRef]
  42. Ankley, G.T.; Bennett, R.S.; Erickson, R.J.; Hoff, D.J.; Hornung, M.W.; Johnson, R.D.; Mount, D.R.; Nichols, J.W.; Russom, C.L.; Schmieder, P.K. Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment. Environ. Toxicol. Chem. Int. J. 2010, 29, 730–741. [Google Scholar] [CrossRef]
  43. Hooper, M.J.; Ankley, G.T.; Cristol, D.A.; Maryoung, L.A.; Noyes, P.D.; Pinkerton, K.E. Interactions between chemical and climate stressors: A role for mechanistic toxicology in assessing climate change risks. Environ. Toxicol. Chem. 2013, 32, 32–48. [Google Scholar] [CrossRef] [Green Version]
  44. Armitage, J.M.; Quinn, C.L.; Wania, F. Global climate change and contaminants—An overview of opportunities and priorities for modelling the potential implications for long-term human exposure to organic compounds in the Arctic. J. Environ. Monit. 2011, 13, 1532–1546. [Google Scholar] [CrossRef] [Green Version]
  45. Boxall, A.B.; Hardy, A.; Beulke, S.; Boucard, T.; Burgin, L.; Falloon, P.D.; Haygarth, P.M.; Hutchinson, T.; Kovats, R.S.; Leonardi, G. Impacts of climate change on indirect human exposure to pathogens and chemicals from agriculture. Environ. Health Perspect. 2009, 117, 508–514. [Google Scholar] [CrossRef] [Green Version]
  46. Macdonald, R.W.; Mackay, D.; Li, Y.-F.; Hickie, B. How will global climate change affect risks from long-range transport of persistent organic pollutants? Hum. Ecol. Risk Assess. 2003, 9, 643–660. [Google Scholar] [CrossRef]
  47. Moretti, A.; Pascale, M.; Logrieco, A.F. Mycotoxin risks under a climate change scenario in Europe. Trends Food Sci. Technol. 2019, 84, 38–40. [Google Scholar] [CrossRef]
  48. Potapowicz, J.; Szumińska, D.; Szopińska, M.; Polkowska, Ż. The influence of global climate change on the environmental fate of anthropogenic pollution released from the permafrost: Part I. Case study of Antarctica. Sci. Total Environ. 2019, 651, 1534–1548. [Google Scholar] [CrossRef]
  49. UNEP Climate Change and POPs: Predicting the Impacts. Report of the UNEP/AMAP Expert Group. Available online: https://oaarchive.arctic-council.org/handle/11374/734?show=full (accessed on 30 August 2022).
  50. Borgå, K.; McKinney, M.A.; Routti, H.; Fernie, K.J.; Giebichenstein, J.; Hallanger, I.; Muir, D.C. The influence of global climate change on accumulation and toxicity of persistent organic pollutants and chemicals of emerging concern in Arctic food webs. Environ. Sci. Process. Impacts 2022, 24, 1544–1576. [Google Scholar] [CrossRef]
  51. Gavrilescu, M. Fate of pesticides in the environment and its bioremediation. Eng. Life Sci. 2005, 5, 497–526. [Google Scholar] [CrossRef]
  52. Kookana, R.S.; Baskaran, S.; Naidu, R. Pesticide fate and behaviour in Australian soils in relation to contamination and management of soil and water: A review. Soil Res. 1998, 36, 715–764. [Google Scholar] [CrossRef]
  53. DeLorenzo, M.E.; Wallace, S.C.; Danese, L.E.; Baird, T.D. Temperature and salinity effects on the toxicity of common pesticides to the grass shrimp, Palaemonetes pugio. J. Environ. Sci. Health Part B 2009, 44, 455–460. [Google Scholar] [CrossRef] [Green Version]
  54. Landis, W.G.; Durda, J.L.; Brooks, M.L.; Chapman, P.M.; Menzie, C.A.; Stahl, R.G., Jr.; Stauber, J.L. Ecological risk assessment in the context of global climate change. Environ. Toxicol. Chem. 2013, 32, 79–92. [Google Scholar] [CrossRef]
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Utembe, W.; Sanabria, N.M. Occupational and Environmental Chemical Risk Assessment in a Changing Climate: A Critical Analysis of the Current Discourse and Future Perspectives. Environ. Sci. Proc. 2022, 24, 2. https://doi.org/10.3390/ECERPH-4-13105

AMA Style

Utembe W, Sanabria NM. Occupational and Environmental Chemical Risk Assessment in a Changing Climate: A Critical Analysis of the Current Discourse and Future Perspectives. Environmental Sciences Proceedings. 2022; 24(1):2. https://doi.org/10.3390/ECERPH-4-13105

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Utembe, Wells, and Natasha M. Sanabria. 2022. "Occupational and Environmental Chemical Risk Assessment in a Changing Climate: A Critical Analysis of the Current Discourse and Future Perspectives" Environmental Sciences Proceedings 24, no. 1: 2. https://doi.org/10.3390/ECERPH-4-13105

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