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Optics, Volume 4, Issue 2 (June 2023) – 11 articles

Cover Story (view full-size image): Optical detection of fluorescence of ICG accumulated in tumor lesions can be used to improve the success rate of image-guided liver biopsies. The choice of detection technology determines the performance of the device and its usability and footprint. Previous works used a camera coupled to a thin borescope to capture and quantify fluorescence intensity. By replacing the camera with a photodiode detector, the temporal resolution is improved in a more compact and lighter device. This work presents a comparative study between both detection technologies, evaluating their performance detecting fluorescent lesions in the liver and the effect of the presence of background fluorescence. View this paper
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21 pages, 2539 KiB  
Article
Near-Field Single-Scattering Calculations of Aerosols: Sensitivity Studies
by Nkongho Ayuketang Arreyndip, Konrad Kandler and Aryasree Sudharaj
Optics 2023, 4(2), 375-395; https://doi.org/10.3390/opt4020028 - 14 Jun 2023
Cited by 1 | Viewed by 1074
Abstract
We model the effects of the photosensitive parameters of aerosols on their optical properties to provide a solid framework for further experimental and theoretical studies. A spherical dust particle is used to study the effects of the ambient medium, size, surface roughness, wavelength, [...] Read more.
We model the effects of the photosensitive parameters of aerosols on their optical properties to provide a solid framework for further experimental and theoretical studies. A spherical dust particle is used to study the effects of the ambient medium, size, surface roughness, wavelength, and imaginary part of the complex refractive index. Five Gaussian random spheres with different aspect ratios are simulated to study the dependence of aerosol light scattering properties on particle shape distribution. To investigate the influence of composition, we model two typical kaolinite-like particles (pure and composite) collected from Southwest Sahara, with 0 and 2% hematite at different mixing states. Using the method of discrete-dipole approximation in DDSCAT, a comparative study is performed with the Mueller matrix elements, scattering, absorption, extinction efficiencies, single scattering albedo, and linear depolarization ratio as indicators. For single, microscopic dust particles, near-field calculations are carried out. The results show that the intensity of backscattering and the scattering efficiency decreases in water compared to dry air. Light in the visible range is more efficient for aerosol scattering experiments. A small number of impurities in the sample will increase its absorbing properties, but, in general, the scattering efficiencies strongly depend on the single-particle mixing state. Smaller particles with a diameter comparable to the wavelength of incident light show higher scattering efficiencies but lower backscattering intensities than larger particles, while surface roughness is shown to strongly alter the polarizability of the particle but has a negligible effect on its single-scattering albedo. Moreover, different shapes have a strong effect on the degree of linear polarization, but, in general, using the spherical over elliptic shape model can underestimate the scattering efficiencies by up to 4%. Finally, variation in the imaginary part of the complex RI can underestimate the single scattering albedo by up to 35.8%. Full article
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11 pages, 1841 KiB  
Article
Effect of Higher Order Aberrations and Intraocular Scatter on Optical Quality Based on an Optical Eye Model
by Feng Rao, Xing Heng Zhao, Ming Dong Zhang and Yan Wang
Optics 2023, 4(2), 364-374; https://doi.org/10.3390/opt4020027 - 26 May 2023
Viewed by 1011
Abstract
The impact of intraocular scatter and higher order aberrations (HOAs) on ocular optical quality was investigated. An optical eye model was constructed using the measured ocular aberrations, corneal surfaces, axial length, and scatter fraction, and the impact of HOAs and scatter on modulation [...] Read more.
The impact of intraocular scatter and higher order aberrations (HOAs) on ocular optical quality was investigated. An optical eye model was constructed using the measured ocular aberrations, corneal surfaces, axial length, and scatter fraction, and the impact of HOAs and scatter on modulation transfer functions (MTFs) was studied based on the newly established optical eye model. For uniform intraocular scatter, the monochromatic and polychromatic MTF decreased as the HOAs or scatter fractions increased independently at each spatial frequency, which implied that both were essential for visual quality. In addition, the scatter effect on MTF was more significant for the eye with less HOA. The combined deterioration effect of these two factors on the MTF was less than their summation, suggesting a potential compensatory mechanism between HOAs and scatter. Full article
(This article belongs to the Special Issue Advances in Vision Optics, Myopia Control and Refractive Surgery)
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13 pages, 1438 KiB  
Review
Tunability of the Optical Properties of Transition-Metal-Based Structural Phase Change Materials
by Sheheera Irfan, Yasir A. Haleem, Muhammad Imran Irshad, Muhammad Farooq Saleem, Muhammad Arshad and Muhammad Habib
Optics 2023, 4(2), 351-363; https://doi.org/10.3390/opt4020026 - 24 May 2023
Cited by 1 | Viewed by 1524
Abstract
Phase transitions are an intriguing yet poorly understood aspect of transition-metal-based materials; these phase transitions can result in changes to the refractive index, absorption coefficient, and other optical properties of the materials. Transition-metal-based materials exist in a variety of crystalline phases and also [...] Read more.
Phase transitions are an intriguing yet poorly understood aspect of transition-metal-based materials; these phase transitions can result in changes to the refractive index, absorption coefficient, and other optical properties of the materials. Transition-metal-based materials exist in a variety of crystalline phases and also have metallic, semi-metallic, and semi-conducting characteristics. In this review, we demonstrate that alloyed W- and Mo-based dichalcogenides enable phase transitions in structures, with phase transition temperatures that are tunable across a wide range using various alloy models and modern DFT-based calculations. We also analyze the tuning the optical bandgap of the metal oxide nanoparticles through doping of the transition metal in a manner that is suitable for optical switching and thermal imaging. After the introduction and a brief illustration of the structures and their exceptional properties, we discuss synthetic methodologies and their application as part of important strategies toward the enhanced performance of transition-metal-based dichalcogenides and oxides. In the end, our conclusion highlights the prospects of 2D materials as phase transition materials due to their advantages in terms of scalability and adaptability. Full article
(This article belongs to the Special Issue Opto-Thermo-Mechanical Interactions in Nano-Objects and Metasurfaces)
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11 pages, 4027 KiB  
Article
Advantages of a Photodiode Detector Endoscopy System in Fluorescence-Guided Percutaneous Liver Biopsies
by Asier Marcos-Vidal, Pedram Heidari, Sheng Xu, Bradford J. Wood and Umar Mahmood
Optics 2023, 4(2), 340-350; https://doi.org/10.3390/opt4020025 - 15 May 2023
Viewed by 1084
Abstract
Image-guided liver biopsies can improve their success rate when combined with the optical detection of Indocyanine Green (ICG) fluorescence accumulated in tumors. Previous works used a camera coupled to a thin borescope to capture and quantify images from fluorescence emission during procedures; however, [...] Read more.
Image-guided liver biopsies can improve their success rate when combined with the optical detection of Indocyanine Green (ICG) fluorescence accumulated in tumors. Previous works used a camera coupled to a thin borescope to capture and quantify images from fluorescence emission during procedures; however, light-scattering prevented the formation of sharp images, and the time response for weakly fluorescent tumors was very low. Instead, replacing the camera with a photodiode detector shows an improved temporal resolution in a more compact and lighter device. This work presents the new design in a comparative study between both detection technologies, including an assessment of the temporal response and sensitivity to the presence of background fluorescence. Full article
(This article belongs to the Special Issue Advances in Biophotonics Using Optical Microscopy Techniques)
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10 pages, 3674 KiB  
Article
Self-Contained Reference Sensors to Reduce Nuisance Alarm Rate in φ-OTDR-Based Fence Intrusion Detection System
by Hailiang Zhang, Hui Dong, Dora Juan Juan Hu and Jun Hong Ng
Optics 2023, 4(2), 330-339; https://doi.org/10.3390/opt4020024 - 15 May 2023
Viewed by 1167
Abstract
Nuisance alarm rate (NAR) is one of the key performance parameters in a phase-sensitive optical time domain reflectometry (φ-OTDR)-based fence intrusion detection system. Typically, the vibrations caused by ambient environmental conditions, such as heavy rain, strong wind, and passing vehicles, easily result in [...] Read more.
Nuisance alarm rate (NAR) is one of the key performance parameters in a phase-sensitive optical time domain reflectometry (φ-OTDR)-based fence intrusion detection system. Typically, the vibrations caused by ambient environmental conditions, such as heavy rain, strong wind, and passing vehicles, easily result in many nuisance alarms. Significant research efforts have been undertaken to suppress the NAR. In this paper, we propose to utilize short segments of the sensing fiber as reference sensors for significant reduction in the NAR in φ-OTDR for the first time, to the best of our knowledge. According to our field trial results, the proposed approach can reduce the NAR by more than 90%. The proposed approach is very simple, practical, and cost-effective, which can be easily integrated with the existing methods of reducing NAR and act as an additional level of decision-making algorithm for triggering alarms. Full article
(This article belongs to the Topic Advances in Optical Sensors)
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9 pages, 1679 KiB  
Article
Disinfection of Transparent Screens by Side-Coupled UVA LED Radiation
by Ben Sicks, Anna-Maria Gierke, Florian Sommerfeld, Martin Klein and Martin Hessling
Optics 2023, 4(2), 321-329; https://doi.org/10.3390/opt4020023 - 15 May 2023
Cited by 1 | Viewed by 878
Abstract
(1) Background: Applications using touch screens are increasingly deployed in medical facilities, as well as in public areas. When touching the display with fingers, potentially pathogenic microorganisms such as methicillin-resistant Staphylococcus aureus (MRSA) can be transmitted. An automated process to decontaminate the device [...] Read more.
(1) Background: Applications using touch screens are increasingly deployed in medical facilities, as well as in public areas. When touching the display with fingers, potentially pathogenic microorganisms such as methicillin-resistant Staphylococcus aureus (MRSA) can be transmitted. An automated process to decontaminate the device in between users would be highly useful. (2) Methods: Thin glass plates were superficially contaminated with the non-pathogenic Staphylococcus carnosus in a controlled manner. Subsequently, UVA radiation of 400 or 380 nm was laterally coupled into the glass plate, which acted as a light guide. Contact agar plates recorded the change in the staphylococci concentration over time. Additionally, the UVA radiation emitted by the glass plates was measured and the potential risk to humans assessed. (3) Results: Staphylococci concentration decreased as a result of UVA radiation for both wavelengths. At 400 nm, it took about 7.5 h and at 380 nm about 1 h until a reduction of 90% was reached. To meet higher disinfection requirements, disproportionately longer irradiation times were necessary. The potential UVA irradiation of humans in front of the glass pane was about 35 µW/cm2 or less and posed no risk to humans. (4) Conclusions: Side-coupled UVA radiation is in principle capable of safely automatically disinfecting microorganisms on touch screens. However, the required irradiation times are still in the hour range, so that a rapid disinfection within a minute or less is not yet possible with the presented setup. However, higher UVA intensities might reduce the current disinfection durations. Full article
(This article belongs to the Section Biomedical Optics)
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11 pages, 2803 KiB  
Article
Advanced Raman Spectroscopy Based on Transfer Learning by Using a Convolutional Neural Network for Personalized Colorectal Cancer Diagnosis
by Dimitris Kalatzis, Ellas Spyratou, Maria Karnachoriti, Maria Anthi Kouri, Spyros Orfanoudakis, Nektarios Koufopoulos, Abraham Pouliakis, Nikolaos Danias, Ioannis Seimenis, Athanassios G. Kontos and Efstathios P. Efstathopoulos
Optics 2023, 4(2), 310-320; https://doi.org/10.3390/opt4020022 - 27 Apr 2023
Cited by 6 | Viewed by 1583
Abstract
Advanced Raman spectroscopy (RS) systems have gained new interest in the field of medicine as an emerging tool for in vivo tissue discrimination. The coupling of RS with artificial intelligence (AI) algorithms has given a boost to RS to analyze spectral data in [...] Read more.
Advanced Raman spectroscopy (RS) systems have gained new interest in the field of medicine as an emerging tool for in vivo tissue discrimination. The coupling of RS with artificial intelligence (AI) algorithms has given a boost to RS to analyze spectral data in real time with high specificity and sensitivity. However, limitations are still encountered due to the large amount of clinical data which are required for the pre-training process of AI algorithms. In this study, human healthy and cancerous colon specimens were surgically resected from different sites of the ascending colon and analyzed by RS. Two transfer learning models, the one-dimensional convolutional neural network (1D-CNN) and the 1D–ResNet transfer learning (1D-ResNet) network, were developed and evaluated using a Raman open database for the pre-training process which consisted of spectra of pathogen bacteria. According to the results, both models achieved high accuracy of 88% for healthy/cancerous tissue discrimination by overcoming the limitation of the collection of a large number of spectra for the pre-training process. This gives a boost to RS as an adjuvant tool for real-time biopsy and surgery guidance. Full article
(This article belongs to the Special Issue Advances in Biophotonics Using Optical Microscopy Techniques)
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10 pages, 1016 KiB  
Article
Photonic Crystals Fabricated by Two-Photon Polymerization with Mechanical Defects
by Victoria Paige Stinson, Nuren Shuchi, Dustin Louisos, Micheal McLamb, Glenn D. Boreman and Tino Hofmann
Optics 2023, 4(2), 300-309; https://doi.org/10.3390/opt4020021 - 04 Apr 2023
Cited by 1 | Viewed by 1418
Abstract
One-dimensional photonic crystals have been used in sensing applications for decades, due to their ability to induce highly reflective photonic bandgaps. In this study, one-dimensional photonic crystals with alternating low- and high-density layers were fabricated from a single photosensitive polymer (IP-Dip) by two-photon [...] Read more.
One-dimensional photonic crystals have been used in sensing applications for decades, due to their ability to induce highly reflective photonic bandgaps. In this study, one-dimensional photonic crystals with alternating low- and high-density layers were fabricated from a single photosensitive polymer (IP-Dip) by two-photon polymerization. The photonic crystals were modified to include a central defect layer with different elastic properties compared to the surrounding layers, for the first time. It was observed that the defect mode resonance can be controlled by compressive force. Very good agreement was found between the experimentally measured spectra and the model data. The mechanical properties of the flexure design used in the defect layer were calculated. The calculated spring constant is of similar magnitude to those reported for microsprings fabricated on this scale using two-photon polymerization. The results of this study demonstrate the successful control of a defect resonance in one-dimensional photonic crystals fabricated by two-photon polymerization by mechanical stimuli, for the first time. Such a structure could have applications in fields, such as micro-robotics, and in micro-opto–electro–mechanical systems (MOEMSs), where optical sensing of mechanical fluctuations is desired. Full article
(This article belongs to the Special Issue Opto-Thermo-Mechanical Interactions in Nano-Objects and Metasurfaces)
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12 pages, 1975 KiB  
Article
GANs-Based Intracoronary Optical Coherence Tomography Image Augmentation for Improved Plaques Characterization Using Deep Neural Networks
by Haroon Zafar, Junaid Zafar and Faisal Sharif
Optics 2023, 4(2), 288-299; https://doi.org/10.3390/opt4020020 - 29 Mar 2023
Viewed by 1267
Abstract
Data augmentation using generative adversarial networks (GANs) is vital in the creation of new instances that include imaging modality tasks for improved deep learning classification. In this study, conditional generative adversarial networks (cGANs) were used on a dataset of OCT (Optical Coherence Tomography)-acquired [...] Read more.
Data augmentation using generative adversarial networks (GANs) is vital in the creation of new instances that include imaging modality tasks for improved deep learning classification. In this study, conditional generative adversarial networks (cGANs) were used on a dataset of OCT (Optical Coherence Tomography)-acquired images of coronary atrial plaques for synthetic data creation for the first time, and further validated using deep learning architecture. A new OCT images dataset of 51 patients marked by three professionals was created and programmed. We used cGANs to synthetically populate the coronary aerial plaques dataset by factors of 5×, 10×, 50× and 100× from a limited original dataset to enhance its volume and diversification. The loss functions for the generator and the discriminator were set up to generate perfect aliases. The augmented OCT dataset was then used in the training phase of the leading AlexNet architecture. We used cGANs to create synthetic images and envisaged the impact of the ratio of real data to synthetic data on classification accuracy. We illustrated through experiments that augmenting real images with synthetic images by a factor of 50× during training helped improve the test accuracy of the classification architecture for label prediction by 15.8%. Further, we performed training time assessments against a number of iterations to identify optimum time efficiency. Automated plaques detection was found to be in conformity with clinical results using our proposed class conditioning GAN architecture. Full article
(This article belongs to the Section Biomedical Optics)
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16 pages, 4565 KiB  
Article
Degree of Polarization of Cathodoluminescence from a GaAs Facet in the Vicinity of an SiN Stripe
by Daniel T. Cassidy, Jean-Pierre Landesman, Merwan Mokhtari, Philippe Pagnod-Rossiaux, Marc Fouchier and Christian Monachon
Optics 2023, 4(2), 272-287; https://doi.org/10.3390/opt4020019 - 23 Mar 2023
Cited by 1 | Viewed by 1516
Abstract
Measurements of the cathodoluminescence (CL) and the degree of polarization (DOP) of (CL) from the facet of a GaAs substrate and in the vicinity of a SiN stripe are reported and analyzed. The deformation induced by the SiN stripe is estimated by fitting [...] Read more.
Measurements of the cathodoluminescence (CL) and the degree of polarization (DOP) of (CL) from the facet of a GaAs substrate and in the vicinity of a SiN stripe are reported and analyzed. The deformation induced by the SiN stripe is estimated by fitting the measured DOP to 3D finite element method (FEM) simulations. The deformation is found to be more complex than an initial condition of biaxial stress in the SiN. A ratio of fit coefficients suggests that the dependence of DOP on strain is described by equations presented in Appl. Opt. 59, 5506–5520 (2020). These equations give a DOP that is either proportional to a weighted difference of the principal components of strain in the measurement plane, or proportional to the shear strain in the measurement plane, depending on the chosen orientation of the measurement axes. Full article
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14 pages, 3278 KiB  
Article
Transition of Orbital Electrons by Electromagnetic Waves
by Muhammad Muhibbullah and Yasuro Ikuma
Optics 2023, 4(2), 258-271; https://doi.org/10.3390/opt4020018 - 23 Mar 2023
Viewed by 1823
Abstract
An electromagnetic (EM) wave is a form of continuous energy, of which both the frequency and the amplitude are parts, as shown in a recent report. All the facts relating to the photoelectric effect are explained by the new modified EM wave concept. [...] Read more.
An electromagnetic (EM) wave is a form of continuous energy, of which both the frequency and the amplitude are parts, as shown in a recent report. All the facts relating to the photoelectric effect are explained by the new modified EM wave concept. Since the photon concept is not able to explain the intensity effect and the ejection direction clearly, it cannot be used to explain nonlinear optical phenomena clearly. The current understanding of the interaction process between orbital electrons and light may not be realistic. In this work, the electron transition process is explained with the new modified EM wave concept. The orbital electrons of a material rotate circularly by the sinusoidal fields of the EM waves. In this way, the electrons absorb light energy as rotational kinetic energy. During the first rotational cycle, the electrons with large enough radii face different potential barriers in neighboring orbits. Consequently, the electrons’ speed is obstructed, and the electrons move behind their natural places (phase); in other words, the electrons cannot follow the required phase of EM waves. Thus, sufficient energetic electrons are scattered from their orbit. The high-intensity EM waves reach the inner orbits of the targeted atom and transit electrons from different orbits. The light can regenerate through processes with different frequencies. The frequency of the regenerated light can be higher than that of primary light, depending on the energy (frequency and amplitude) of the primary light. The results of previous reports match the prediction of the new concept of EM waves. The new wave concept may be able to explain all photonic behaviors of light clearly. Full article
(This article belongs to the Section Nonlinear Optics)
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