J, Volume 5, Issue 4 (December 2022) – 9 articles

Kupffer cells (KCs) are resident macrophages in the liver. Recent studies have revealed that KCs are closely related to inflammatory liver diseases, including nonalcoholic liver diseases (NAFLD). From this point of view, KC transplantation can be a candidate for immunotherapy against inflammatory diseases. Similar to general macrophages, KCs show several different phenotypes according to their environment. Activated KCs are involved in either proinflammatory responses or anti-inflammatory responses. Thus, to manipulate KCs for immunotherapy, it is crucial to control the direction of KC activation. Here, we summarize the outlook and the issues hindering immunotherapy using KC transplantation. Full article

Environmental protection is an important key to achieving sustainable development. Since humans depend on the environment in countless ways, preserving them contributes directly to the sustaining of people and human societies and hence, to social sustainability. The central question in this dissertation asks why the environmental protection policies enacted in Madagascar are not efficient and how they impact the SDG’s achievement at the national level. This paper discusses Madagascar’s achievements of the sustainable development target with special emphasis on environmental issues, which is currently a major concern in the country. This review aimed at suggesting improvements in line with the challenges the country is facing by reviewing the indicators provided by the UN SDGs. It also reaffirmed the nexus of poverty and the environment, which is important for setting the development target. In order to conduct this study, journal articles, review papers, working papers, research reports, and books related to environmental management and sustainable development in Madagascar were reviewed. Madagascar has made a little improvement in accomplishing SDGs 12 and 13 in 2021, but achieving all SDGs goals in 2030 remains a big challenge. The country is a party to numerous international environmental conventions, treaties, and agreements. Many policy changes have been implemented to address both conservation and development issues, but these efforts have had little impact. Forest fires and slash-and-burn were on the rise in Madagascar on October 2022, which poses a major concern for the economic and social development of the island. In order to achieve sustainable development, environmental protection shall constitute an integral part of the development process and cannot be considered in isolation from it. The strategies proposed in this paper might be helpful for the Malagasy government and private sector in decision-making. This paper is also useful for researchers in developing countries. As Madagascar did not reach the Millennium Development Goals 2015 and will not achieve the SDGs in 2030, should we not start learning from our mistakes and thinking about the post-SDGs? Full article

The number of child abuse cases has been increasing in Japan every year. Medical institutions face issues such as coordinating with welfare offices, child guidance centers, police, and other related agencies concerning child abuse, as well as communicating with parents/guardians who are perpetrators of child abuse. This study examined the awareness and actual behavior of medical institutions regarding the support required while notifying/reporting cases of child abuse. A self-administered and anonymous questionnaire survey was conducted among the staff of the pediatrics departments, emergency departments, and general affairs departments of large hospitals in Japan. Differences in notifying and reporting child abuse cases to the child guidance center and welfare office and the police were assessed. It was found that some cases were not reported to the child guidance center or welfare office despite being considered “abuse.” Furthermore, a difference of opinion was observed among staff members, especially in judging “whether abuse is suspected or not.” Full article

The factors contributing to urbanization, such as population growth and the development of mega-cities, have increased environmental stressors on top of everyday stressors, resulting in information overload. This has led to the increasing incidence of direct attentional fatigue, which causes stress and mental fatigue. The attention restoration theory centres on the environment’s capacity to restore attentional deficits and suggests that there are certain qualities in the environment that restore attention, which leads to improvements in our physical, mental, and social well-being. An environment can be restorative through the activation of involuntary attention, which limits the need for directed attention. This study explored for effects of natural, built, and mixed environment types and levels of mystery on attention restoration in university undergraduates. Perceived and actual levels of attention restoration were measured using a perceived restoration scale (PRS) and the digit symbol substitution task (DSST), respectively. A total of 101 participants viewed a restorative image followed by the completion of the DSST and the PRS for each of the 18 images depicting different environments. Actual attention restoration was measured by latency values in the DSST instead of through both speed and error rates due to some operational issues with the DSST which interfered with the full achievement of the study’s aims. There was an effect of different environments and mystery on perceived attention restoration. However, there appeared to be no effect on actual attention restoration, indicating a disconnect between perceived and actual restoration. Further research is required to confirm the specific effects of natural and built environments and mystery on attention restoration. Full article

Cancer threatens nutritional status, and many patients will become cachectic with a negative impact on prognosis. In the TiCaCo pilot trial, we showed a positive effect of calorie matching Nutrition Therapy on both morbidity and mortality. We attempt to validate these results in the TiCaCONCO trial. In a prospective, randomized, single-blinded, controlled trial, patients were treated with either intensive, individual biometric parameter-oriented dietary counseling (nutrition therapy or NT) for a maximum period of three months, or regular dietary counseling (control or CT), before and during conventional cancer treatment. Sixty patients were enrolled over a two-year period, with 30 receiving nutrition therapy and 30 being controls. The primary endpoint was overall survival (OS). Overall survival at 12 months in all patients was 47% (14/30 patients) in the CT group with a median OS of 45.5 weeks, and 73% (22/30 patients) in the NT group with a median OS that was undefined (i.e., cannot be calculated, as >50% of patients in the NT group were still alive at the end of the study) (p = 0.0378). The survival difference still exists when only male patients are analyzed, but is not observed in female patients. Biophysical measurements were performed at 0, 3, and 12 months in all patients. In men, the differences between CT vs NT were statistically significant for body hydration (p = 0.0400), fat mass (p = 0.0480), total energy expenditure (p = 0.0320), and median overall survival at 12 months (p = 0.0390). At 3 months (end of the intervention), the differences between CT vs NT for body hydration were 73 ± 3% vs. 75 ± 5%, for fat mass 14 ± 4% vs. 19 ± 5%, and for total energy expenditure 2231 ± 637 Kcal vs. 2408 ± 369 Kcal. In women, the differences between CT vs NT were not statistically significant for body hydration (p = 1.898), fat mass (p = 0.9495), total energy expenditure (p = 0.2875) and median overall survival at 12 months (p = 0.6486). At 3 months (end of the intervention), the differences between CT vs. NT for body hydration were 74 ± 2% vs. 78 ± 5%, for fat mass 25 ± 7% vs. 29 ± 19%, and for TEE 1657 ± 297 Kcal vs. 1917 ± 120 Kcal. Nutrition Therapy, based on patient-specific biophysical parameters, including the measurement of metabolism by indirect calorimetry and body composition measurements by BIA, improves overall survival, at least in men. The mechanism would be increasing extra energy for the body, which is necessary to fight off cancer. Full article

The aim of this research was to evaluate how the quality interior design aspects of the staff office spaces at the Girls’ College of Science and Arts, King Khalid University, Saudi Arabia, affect their happiness, comfort and performance of their duties, and also proposes a solution based on the sciences of the relationship between happiness and interior design. The aim was achieved by carrying out a survey on staff of the college. The participants were selected using a combination of probabilistic and random sampling. The research found that a good number of staff at the college are not happy with their work environments. Further analysis indicated that interior design deficiency is a major cause of unhappiness of staff at the college. The results showed that this may be attributed to three important aspects of quality interior space furniture: insufficiency of furniture and other workspace items; lack of aesthetics, functionality, comfort, color and materials (low quality materials) of furniture and other workspace items; and a lack of sufficient natural lighting being another major issue affecting the quality of natural and artificial lighting in some offices at the college. Participants were also not comfortable with some materials used in the interior space. The study recommends that office spaces should be redesigned to meet the following interior design criteria: appropriateness for the workplace (size, lighting and materials); color and decorations (non-dark colors); and appropriate accessories and tools of work. Full article

During disease or toxin challenges, the behavioral activities of grazing animals alter in response to adverse situations, potentially providing an indicator of their welfare status. Behavioral changes such as feeding behavior, rumination and physical behavior as well as expressive behavior, can serve as indicators of animal health and welfare. Sometimes behavioral changes are subtle and occur gradually, often missed by infrequent visual monitoring until the condition becomes acute. There is growing popularity in the use of sensors for monitoring animal health. Acceleration sensors have been designed to attach to ears, jaws, noses, collars and legs to detect the behavioral changes of cattle and sheep. So far, some automated acceleration sensors with high accuracies have been found to have the capacity to remotely monitor the behavioral patterns of cattle and sheep. These acceleration sensors have the potential to identify behavioral patterns of farm animals for monitoring changes in behavior which can indicate a deterioration in health. Here, we review the current automated accelerometer systems and the evidence they can detect behavioral patterns of animals for the application of potential directions and future solutions for automatically monitoring and the early detection of health concerns in grazing animals. Full article

The presence of eriochrome black T (EBT) dye in waste water causes a significant hazard to human health and ecology. In the current study, biosorption was employed to eliminate EBT from water. Thus, we utilized endophytic fungi strain Exserohilum rostratum NMS1.5 mycelia biomass as biosorbent agent. The process was carried out at room temperature by magnetic stirring. The results indicated that an increase in pH would decrease adsorption capacity and removal percentage. In addition, an increased EBT concentration would decrease the removal percentage and increase biosorption capacity. The equilibrium time indicated that after 300 min of mixing, the percentage removal and biosorption capacity were 80.5% and 100.61 mg/g, respectively. The biosorption isotherms and kinetics were compatible with the Freundlich model and the pseudo-second-order. This research indicates that E. rostratum NMS1.5 may be utilized as an environmentally friendly and affordable alternative biosorbent material for EBT removal. Full article

River renaturation can be an effective management method for restoring a floodplain’s natural capacity and minimizing the effects during high flow periods. A 1D-2D Hydrologic Engineering Center–River Analysis System (HEC-RAS) model, in which the flood plain was considered as 2D and the main channel as 1D, was used to simulate flooding in the restored reach of the Spree River, Germany. When computing in this model, finite volume and finite difference approximations using the Preissmann approach are used for the 1D and 2D models, respectively. To comprehend the sensitivity of the parameters and model, several scenarios were simulated using different time steps and grid sizes. Additionally, dikes, dredging, and changes to the vegetation pattern were used to simulate flood mitigation measures. The model predicted that flooding would occur mostly in the downstream portion of the channel in the majority of the scenarios without mitigation measures, whereas with mitigation measures, flooding in the floodplain would be greatly reduced. By preserving the natural balance on the channel’s floodplain, the restored area needs to be kept in good condition. Therefore, mitigating measures that balance the area’s economic and environmental aspects must be considered in light of the potential for floods. Full article