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Advances in Respiratory Medicine is published by MDPI from Volume 90 Issue 4 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Via Medica.

Adv. Respir. Med., Volume 89, Issue 1 (February 2021) – 25 articles , Pages 1-100

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473 KiB  
Article
Miniforceps EBUS-Guided Lymph Node Biopsy: Impact on Diagnostic Yield
by Aryan Shiari, Lamia Aljundi, Peter Boshara, Rami K. Zein and Mohammed Zalt
Adv. Respir. Med. 2021, 89(1), 37-42; https://doi.org/10.5603/ARM.a2021.0024 - 28 Feb 2021
Cited by 3 | Viewed by 660
Abstract
Introduction: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is the standard diagnostic method for sampling mediastinal and hilar lymph nodes. Non-diagnostic samples have led some pulmonologists to add a miniforceps biopsy (EBUS-TBFB) in order to increase diagnostic yield. Our study aims to analyze the [...] Read more.
Introduction: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is the standard diagnostic method for sampling mediastinal and hilar lymph nodes. Non-diagnostic samples have led some pulmonologists to add a miniforceps biopsy (EBUS-TBFB) in order to increase diagnostic yield. Our study aims to analyze the impact of adding EBUS-TBFB to the EBUS-TBNA in cases where Rapid On-site Evaluation (ROSE) was negative for malignancy or was non-diagnostic. Material and methods: This retrospective chart review included 91 patients who were aged 18–90 years old and underwent EBUS with both TBNA and TBFB between January 1, 2013 and July 1, 2018. Results: There was no significant statistical difference in the diagnostic yield of TBNA vs TBFB with a McNemar value of 0.167, and this conclusion was the same when stratified by race, age and lymph node size. Using TBNA as a gold standard, the sensitivity and specificity of TBFB was 87% and 69%, respectively. Out of the non-diagnostic TBNA samples on ROSE and cell-block, subsequent TBFB resulted in additional pathologic diagnoses in 16% of cases, of which 67% were non-caseating granulomas. Furthermore, two additional malignant cases were identified by TBFB consisting of small cell carcinoma and non-Hodgkin’s lymphoma. Conclusion: In conclusion, TBFB is a useful adjunctive tool in the diagnosis of non-malignant conditions (i.e., granulomatous diseases) with the potential to spare the patient from more invasive surgical biopsies. Training of future fellows in performing TBFB in addition to TBNA should be strongly encouraged. Full article
1054 KiB  
Article
Vascular Patterns on Narrow Band Imaging (NBI) Video Bronchoscopy of Lung Cancer Patients and Its Relationship with Histology: An Analytical Cross-Sectional Study
by Nishant Kumar Chauhan, Poonam Elhence, Kunal Deokar, Naveen Dutt, Prem Prakash Sharma, Ashok Kuwal, Sunil Kumar and Ram Niwas
Adv. Respir. Med. 2021, 89(1), 30-36; https://doi.org/10.5603/ARM.a2021.0014 - 28 Feb 2021
Cited by 2 | Viewed by 566
Abstract
Introduction: Narrow band imaging (NBI) video bronchoscopy provides better visualisation of submucosal vascular patterns in malignant airway lesions compared to white light bronchoscopy. This analytical cross-sectional study was aimed to look for any relationship between these NBI vascular patterns and the histologic type [...] Read more.
Introduction: Narrow band imaging (NBI) video bronchoscopy provides better visualisation of submucosal vascular patterns in malignant airway lesions compared to white light bronchoscopy. This analytical cross-sectional study was aimed to look for any relationship between these NBI vascular patterns and the histologic type of lung cancer. Material and methods: After screening 78 patients with suspected lung cancer, 53 subjects underwent video bronchoscopy. Thirty-two patients showing abnormal bronchial mucosa or endobronchial growth with any of the NBI vascular patterns on bronchoscopy were enrolled in the study. These abnormal areas were then biopsied and sent for histologic examination. Results: NBI bronchoscopy revealed a dilated tortuous vascular pattern in 54.8% of the patients, a non-specific pattern in 32%, a dotted pattern in 9.7% and an abrupt ending vessels pattern in 3.2% of the patients. We did not find any statistically significant relationship between a dilated tortuous pattern and squamous-cell carcinoma (p = 0.48), adenocarcinoma (p = 0.667) or small-cell carcinoma (p = 1); between a dotted pattern and squamous-cell carcinoma (p = 1), adenocarcinoma (p = 0.54) or small-cell carcinoma (p = 1), and between an abrupt ending capillary pattern and squamous-cell carcinoma (p = 1), adenocarcinoma (p = 1) or small-cell carcinoma (p =1). Conclusion: No relationship exists between NBI vascular patterns and the histology of lung cancer. Endobronchial lesions showing any vascular pattern on NBI needs to be adequately sampled for proper histologic and molecular studies in lung cancer patients. Full article
300 KiB  
Article
The Utility of HACOR Score in Predicting Failure of High-Flow Nasal Oxygen in Acute Hypoxemic Respiratory Failure
by Doaa M. Magdy and Ahmed Metwally
Adv. Respir. Med. 2021, 89(1), 23-29; https://doi.org/10.5603/ARM.a2021.0031 - 28 Feb 2021
Cited by 9 | Viewed by 793
Abstract
Objectives: To assess the diagnostic performance of HACOR scoring system using bedside variables and to predict failure of HFNO in patients with acute hypoxemic respiratory failure (AHRF). Material and methods: 150 patients with AHRF who were receiving HFNO were enrolled in this study; [...] Read more.
Objectives: To assess the diagnostic performance of HACOR scoring system using bedside variables and to predict failure of HFNO in patients with acute hypoxemic respiratory failure (AHRF). Material and methods: 150 patients with AHRF who were receiving HFNO were enrolled in this study; to predict HFNO treatment failure. A scoring scale (HACOR score) consisted of Heart rate (beats/minute), acidosis (assessed by pH), consciousness (assessed by Glasgow coma score), oxygenation, and respiratory rate. Failure was defined as the need for intubation or death. Results: Patients were analyzed according to the success or failure of HFNO. Total 150 patients, of which 100 (66.7%) had a successful treatment while 50 (33.3%) failed with such intervention. There was an improvement in HR and RR, and PaO₂/FiO₂ within the first hour (T1) in the success group and these parameters continued to improve even after 24 hours (T2) of HFNO treatment. Patients with HFNO failure had a higher HACOR score at initiation and after 1, 12, 24 and 48 hours. Before intubation, the highest value of the HACOR score was reached in the failure group. At 1h of HFNO assessment, the area under the receiver operating characteristic curve was 0.86, showing good predictive power for failure. We found that HACOR score at a cutoff point > 6 had 81.2% sensitivity and 91% specificity, 92.5% positive predictive value, and 71.4% negative predictive value with a diagnostic accuracy was 85%. Furthermore, the overall diagnostic accuracy exceeded 87% when the HACOR score was assessed at 1, 12, 24 or 48 h of HFNO. Conclusions: The HACOR scale is a clinically useful bedside tool for the prediction of HFNO failure in hypoxemic patients. A HACOR score < 6 after 1 hour of HFNO highlights patients with < 85% risk of failure. Full article
722 KiB  
Article
Efficacy of Pulmonary Rehabilitation for Bronchiectasis and Related Factors: Which Patients Should Receive the Most Treatment?
by Ipek Candemir, Pınar Ergun, Seher Satar, Harun Karamanlı, Dicle Kaymaz and Nese Demir
Adv. Respir. Med. 2021, 89(1), 15-22; https://doi.org/10.5603/ARM.a2021.0029 - 28 Feb 2021
Cited by 3 | Viewed by 777
Abstract
Introduction: Pulmonary rehabilitation (PR) is an effective approach for patients with chronic pulmonary disease, and it is also recommended for patients with bronchiectasis. The aims of the current study were to evaluate the efficacy of a multidisciplinary PR program and identify factors associated [...] Read more.
Introduction: Pulmonary rehabilitation (PR) is an effective approach for patients with chronic pulmonary disease, and it is also recommended for patients with bronchiectasis. The aims of the current study were to evaluate the efficacy of a multidisciplinary PR program and identify factors associated with improvement in patients with bronchiectasis. Material and ethods: We obtained data from patients with bronchiectasis who completed our PR program which consisted of education and training regarding bronchial hygiene. Pulmonary function test results, body composition, exercise capacity, quality of life, and psychological status were assessed before and after the PR program. Results: We enrolled 130 patients in this retrospective study. Most patients had a history of pneumonia. The Medical Research Council (MRC) dyspnea scale, incremental shuttle walking test (ISWT), endurance shuttle walking test (ESWT), St. George’s Respiratory Questionnaire (SGRQ), Chronic Respiratory Questionnaire (CRQ), and Hospital Anxiety and Depression (HAD) scores statistically improved after the PR program (all p < 0.001). Improvements were similar regardless of sex, etiology, smoking sta-tus, or number of hospitalizations. Age was negatively correlated with ΔSGRQ (p = 0.024, r = −0.203). Baseline forced expiratory volume in 1s (FEV1) was positively correlated with ΔCRQ (p = 0.015, r = 0.213) and negatively correlated with Δanxiety (p = 0.014, r = −0.215). Baseline MRC was negatively correlated with ΔMRC (p < 0.001, r = −0.563) and ΔSGRQ (p < 0.001, r = −0.308). Baseline ISWT was negatively correlated with ΔISWT (p = 0.043, r = −0.176) and Δanxiety (p = 0.007, r = −0.237). Baseline SGRQ was negatively correlated with ΔMRC (p = 0.003, r = −0.267) and ΔSGRQ (p < 0.001, r = −0.648). Conclusions: Our PR program is efficacious for patients with bronchiectasis regardless of sex, etiologic cause of bronchiectasis, concomitant chronic obstructive pulmonary disease, smoking status, and/or number of hospitalizations. Improvement varied among patients which highlights the need for more studies to determine which patients will benefit most from the program. Full article
242 KiB  
Article
Competence in Metered-Dose Inhaler Technique among Healthcare Workers of Three General Hospitals in Mexico: It is Not Good after All These Years
by Carlos David Pérez-Malagón, Raúl Barrera-Rodríguez, Nelly G. Medina Casillas, Juan Pablo Casillas-Muñoz, Graciela Silva-Sánchez and Cynthia Macías-Limón
Adv. Respir. Med. 2021, 89(1), 8-14; https://doi.org/10.5603/ARM.a2021.0027 - 28 Feb 2021
Cited by 1 | Viewed by 557
Abstract
Introduction: Inhaled medication is the cornerstone of pharmacological treatment for chronic respiratory diseases. Therefore, it is important to use a metered-dose inhaler (MDI) correctly to get the appropriate dosage and benefit from the drug. Health-care workers (HCW) are responsible for teaching the correct [...] Read more.
Introduction: Inhaled medication is the cornerstone of pharmacological treatment for chronic respiratory diseases. Therefore, it is important to use a metered-dose inhaler (MDI) correctly to get the appropriate dosage and benefit from the drug. Health-care workers (HCW) are responsible for teaching the correct MDI technique. Unfortunately, numerous studies consistently show that HCW have poor MDI technique. This study aimed to evaluate the current knowledge of MDI technique in HCW working in three general hospitals. Material and methods: A hospital-based, cross-sectional descriptive study was conducted in three general hospitals in Aguascalientes, México. Three surveyors simultaneously scored through a 14 dichotomic questions list as bad, regular, good, and very good MDI technique. Data were analyzed with SPSS version 16. Statistical analyses were performed using chi-square test or unpaired t-tests. An analysis of one-way ANOVA was used for comparison of three independent general hospitals. Values of p < 0.05 were considered to indicate statistical significance. Results: A total of 244 HCWs were surveyed: 78.3% were nurses whereas 21.3% were physicians. The inter-observer concor-dance analysis among observers was 0.97. We observed that 32.4% (79) performed a bad technique, 51.6% (126) a regular technique, 13.5% (33) a good one, and 2.5% HCW (6) a very good technique. No difference between gender, labor category, schedule, service, age, seniority, and education degree between the three hospitals was observed. The most common mistakes were “insufficient expiration prior to activation of the device”, and “the distance the inhaler was placed for inhalation” (83 and 84% respectively). Conclusion: We observed that a high percentage of HCW do not follow the MDI technique correctly, being this percentage even higher than the reported in other studies. These observations suggest the urgent need to establish frequent training programs for the correct use of MDI. Full article
166 KiB  
Letter
Proper Respirators Use Is Crucial for Protecting Both Emergency First Aid Responder and Casualty from COVID-19 and Airborne-Transmitted Infections
by Francesco Chirico, Gabriella Nucera, Angelo Sacco and Nicola Magnavita
Adv. Respir. Med. 2021, 89(1), 99-100; https://doi.org/10.5603/ARM.a2021.0028 - 22 Jan 2021
Cited by 5 | Viewed by 475
Abstract
We read with great interest the paper by Barycka et al. [...] Full article
249 KiB  
Letter
Suction Above Cuff Endotracheal Tube Can Reduce Ventilator-Associated Pneumonia in COVID-19 Patients
by Łukasz Szarpak, Maciej Cyran, Paweł Wieczorek and Togay Evrin
Adv. Respir. Med. 2021, 89(1), 97-98; https://doi.org/10.5603/ARM.a2021.0025 - 28 Dec 2020
Viewed by 555
Abstract
Ventilator-associated pneumonia (VAP) is a type of pneumonia classified as a nosocomial infection associated with mechanical ventilation which occurs 48–72 hours after endotracheal intubation [...] Full article
244 KiB  
Article
Validity of ROX Index in Prediction of Risk of Intubation in Patients with COVID-19 Pneumonia
by Lucy Abdelmabood Suliman, Taha Taha Abdelgawad, Nesrine Saad Farrag and Heba Wagih Abdelwahab
Adv. Respir. Med. 2021, 89(1), 1-7; https://doi.org/10.5603/ARM.a2020.0176 - 17 Dec 2020
Cited by 40 | Viewed by 1048
Abstract
Introduction: One important concern during the management of COVID-19 pneumonia patients with acute hypoxemic respiratory failure is early anticipation of the need for intubation. ROX is an index that can help in identification of patients with low and those with high risk of [...] Read more.
Introduction: One important concern during the management of COVID-19 pneumonia patients with acute hypoxemic respiratory failure is early anticipation of the need for intubation. ROX is an index that can help in identification of patients with low and those with high risk of intubation. So, this study was planned to validate the diagnostic accuracy of the ROX index for prediction of COVID-19 pneumonia outcome (the need for intubation) and, in addition, to underline the significant association of the ROX index with clinical, radiological, demographic data. Material and methods: Sixty-nine RT-PCR positive COVID-19 patients were enrolled. The following data were collected: medical history, clinical classification of COVID-19 infection, the ROX index measured daily and the outcome assessment. Results: All patients with severe COVID-19 infection (100%) were intubated (50% of them on the 3rd day of admission), but only 38% of patients with moderate COVID-19 infection required intubation (all of them on the 3rd day of admission). The ROX index on the 1st day of admission was significantly associated with the presence of comorbidities, COVID-19 clinical classification, CT findings and intubation (p ≤ 0.001 for each of them). Regression analysis showed that sex and ROX.1 are the only significant independent predictors of intubation [AOR (95% CI): 16.9 (2.4– 117), 0.77 (0.69–0.86)], respectively. Cut-off point of the ROX index on the 1st day of admission was ≤ 25.26 (90.2% of sensitivity and 75% of specificity). Conclusions: ROX is a simple noninvasive promising tool for predicting discontinuation of high-flow oxygen therapy and could be used in the assessment of progress and the risk of intubation in COVID-19 patients with pneumonia. Full article
185 KiB  
Article
New Twist to An Old Problem: COVID-19 and Idiopathic Pulmonary Fibrosis
by Pratap Upadhya, Ravindra Chary, Gopal Chawla, Rohit Vadala and Madhusmita Mohanty
Adv. Respir. Med. 2021, 89(1), 84-85; https://doi.org/10.5603/ARM.a2020.0177 - 28 Aug 2020
Cited by 4 | Viewed by 617
Abstract
Pandemic of COVID-19 has brought a pletho-ra of challenges throughout the world and has opened exposed gaps in already overburdened stressful health system [...] Full article
161 KiB  
Letter
Face Shields for Prevention of SARS-CoV-2 in Community—Need of the Hour
by Saurabh Mittal, Anant Mohan, Karan Madan, Tarun Krishna Boppana, Pawan Tiwari and Vijay Hadda
Adv. Respir. Med. 2021, 89(1), 83; https://doi.org/10.5603/ARM.a2020.0185 - 28 Aug 2020
Viewed by 356
Abstract
Since the onset of the current pandemic of coronavirus disease-19 (COVID-19) [...] Full article
161 KiB  
Letter
COVID-19 Pandemic—Did We Sign Up for “This”?
by Nitish Aggarwal, Tarun Krishna Boppana and Saurabh Mittal
Adv. Respir. Med. 2021, 89(1), 96; https://doi.org/10.5603/ARM.a2021.0030 - 27 Aug 2020
Viewed by 367
Abstract
Since the beginning of the pandemic, there is an increasing pressure on our healthcare systems to cope with the increasing workload [...] Full article
237 KiB  
Review
The Prognostic Value of Fixed Time and Self-Paced Walking Tests in Patients Diagnosed with Idiopathic Pulmonary Fibrosis
by Adam J. Białas, Mikołaj Iwański, Joanna Miłkowska-Dymanowska, Michał Pietrzak, Sebastian Majewski, Paweł Górski and Wojciech J. Piotrowski
Adv. Respir. Med. 2021, 89(1), 49-54; https://doi.org/10.5603/ARM.a2020.0193 - 12 Aug 2020
Cited by 2 | Viewed by 554
Abstract
Idiopathic pulmonary fibrosis (IPF) is a specific form of chronic fibrosing interstitial pneumonia that has an unknown etiology. The natural history of the disease is characterized by a progressive decline in pulmonary function and overall health and well-being. The median survival time is [...] Read more.
Idiopathic pulmonary fibrosis (IPF) is a specific form of chronic fibrosing interstitial pneumonia that has an unknown etiology. The natural history of the disease is characterized by a progressive decline in pulmonary function and overall health and well-being. The median survival time is between 2–3 years; however, the disease course is variable and unpredictable. The twelve-minute walking test (12MWT) and six-minute walking test (6MWT) are two fixed time tests that are commonly used in clinical practice. Our short and clinically oriented narrative review attempted to summarize current evidence supporting the use of fixed time, self-paced walking tests in predicting the outcome of patients diagnosed with IPF. A number of studies have justified that the 6MWT is a simple, cost-effective, well documented, fixed time, and self-paced walking test which is a valid and reliable measure of disease status and can also be used as a prognostic tool in patients with IPF. However, there is a need for dedicated and validated reference equations for this population of patients. It is also necessary to fill the knowledge gap about the role of the 12MWT. We hypothesize that it would be useful in evaluating patients that are in the early stages of the disease. Full article
1018 KiB  
Case Report
Thymic Ccancer Superimposed Opacity of the Mediastinal Anatomical Structures
by Masahiro Uchiyama, Yuika Sasatan, Shinichiro Okauchi, Kesato Iguchi, Norio Takayashiki and Hiroaki Satoh
Adv. Respir. Med. 2021, 89(1), 77-78; https://doi.org/10.5603/ARM.a2020.0184 - 09 Aug 2020
Viewed by 540
Abstract
Thymic cancer is a rare malignant neoplasm [...] Full article
163 KiB  
Letter
Awake Proning in COVID-19—Does CPAP Make a Difference?
by Saurabh Mittal, Sryma PB, Karan Madan, Anant Mohan, Pawan Tiwari, Janamejey Gaur and Vijay Hadda
Adv. Respir. Med. 2021, 89(1), 82; https://doi.org/10.5603/ARM.a2020.0179 - 07 Aug 2020
Cited by 2 | Viewed by 373
Abstract
Awake proning is being used as an adjunct to the current therapies for patients with cooronavirus disease 2019 (COVID-19) related hypoxemic respiratory failure [...] Full article
903 KiB  
Letter
Young and Exhausted
by Filip Olekšák, Peter Ďurdík, Ľubica Jakušová, Tomáš Turčan and Peter Bánovčin
Adv. Respir. Med. 2021, 89(1), 92-95; https://doi.org/10.5603/ARM.a2020.0196 - 05 Aug 2020
Viewed by 485
Abstract
Chronic fatigue syndrome/myalgic enceph-alomyelitis (CFS/ME) is a complex [...] Full article
1097 KiB  
Case Report
Systemic Sclerosis-Interstitial Lung Disease with Coexistent Subacute Invasive Pulmonary Aspergillosis: A Rare Association
by Benhur Joel Shadrach, Kunal Deokar, Vikrant Agarwal, Anukool Jain and Rishabh Goel
Adv. Respir. Med. 2021, 89(1), 75-76; https://doi.org/10.5603/ARM.a2020.0183 - 20 Jul 2020
Viewed by 404
Abstract
A 55-year-old female complained of recurrent haemoptysis [...] Full article
826 KiB  
Case Report
Transbronchial Lung Cryobiopsy (TBCB) Performed in Acute COVID-19 Pneumonia: First Report
by Ahmed Ehab, Florian Reissfelder, Juergen Laufer and Axel Tobias Kempa
Adv. Respir. Med. 2021, 89(1), 72-74; https://doi.org/10.5603/ARM.a2021.0032 - 18 Jul 2020
Cited by 1 | Viewed by 454
Abstract
A COVID-19 diagnosis is usually based on PCR detection of viral RNA in airway specimens in a patient with typical clinical fea-tures. Histological features of the COVID-19 lung disease are reported from autopsies. Transbronchial cryobiopsy (TBCB) is an evolving technique usually performed in [...] Read more.
A COVID-19 diagnosis is usually based on PCR detection of viral RNA in airway specimens in a patient with typical clinical fea-tures. Histological features of the COVID-19 lung disease are reported from autopsies. Transbronchial cryobiopsy (TBCB) is an evolving technique usually performed in the diagnosis of interstitial lung disease. We report a TBCB in a 76-year-old female patient who had repeatedly tested negative for SARS-CoV-2 infection. The pathological examination revealed the presence of interstitial pneumonia with lymphocytic infiltration. The qRT-PCR against SARS-CoV-2 from a pharyngeal swab was positive after performing the TBCB. Full article
250 KiB  
Review
Evidence-Based Review of Bronchoscopic Lung Volume Reduction
by Sumita Agrawal, Nitesh Gupta and Hari Kishan Gonuguntla
Adv. Respir. Med. 2021, 89(1), 43-48; https://doi.org/10.5603/ARM.a2020.0172 - 16 Jul 2020
Cited by 1 | Viewed by 485
Abstract
Emphysema sequentially leads to the loss of gas exchanging surface and an abnormal shape of the diaphragm generating dyspnea refractory to standard medical therapy. Lung volume reduction surgery (LVRS) is a surgical treatment option for patients with severe emphysema whose symptoms are uncontrolled [...] Read more.
Emphysema sequentially leads to the loss of gas exchanging surface and an abnormal shape of the diaphragm generating dyspnea refractory to standard medical therapy. Lung volume reduction surgery (LVRS) is a surgical treatment option for patients with severe emphysema whose symptoms are uncontrolled on standard therapy. Bronchoscopic LVR (bLVR) is a process by which lung volume reduction is achieved in a minimally invasive manner using bronchoscopy-guided insertion of valves, coils, sealants, or by thermal vapour ablation like techniques. These therapies have developed over the last few years and have variable results in patients. We have summarized the current evidence available on each of these methods in this review. Full article
209 KiB  
Letter
A Review of Ciclesonide in the Management of COVID-19. Still a Long Way to Go
by Kunal Deokar, Mehul Agarwal, Naveen Dutt, Nishant Chauhan, Ram Niwas, Benhur Joel Shadrach and Gopal Chawla
Adv. Respir. Med. 2021, 89(1), 79-81; https://doi.org/10.5603/ARM.a2020.0173 - 11 Jul 2020
Cited by 7 | Viewed by 581
Abstract
COVID-19 has spread throughout the world infecting 8,018,963 people and claiming 436,138 lives to date [...] Full article
170 KiB  
Letter
Risk Assessment and Prognostic Aspect of Coagulopathy in COVID-19
by Mujibur Rahman and Nadira Naznin Rakhi
Adv. Respir. Med. 2021, 89(1), 90-91; https://doi.org/10.5603/ARM.a2020.0191 - 09 Jul 2020
Viewed by 380
Abstract
Coronavirus disease 2019 (COVID-19) primarily being considered as a respiratory illness has been showing a highly diverse and anomalous array of symptoms since its origin in December 2019 [...] Full article
1799 KiB  
Case Report
Streptomyces Pneumonia in An Immunocompetent Adult—A Rare Isolate
by Muniza Bai, Mahesh Babu Vemur, Madhusmita Mohanty Mohapatra, Shahana Mp, Sujatha Sistla and Radha Sugumaran
Adv. Respir. Med. 2021, 89(1), 68-71; https://doi.org/10.5603/ARM.a2020.0171 - 06 Jul 2020
Cited by 2 | Viewed by 505
Abstract
Streptomyces belongs to the Actinomycetes group of bacteria which are gram-positive non acid-fast bacilli, widely recognised for their potential to produce antimicrobials active against bacterial, mycobacterial, parasitic and fungal infections. They commonly cause cutaneous infections following traumatic inoculation. Visceral infections are relatively rare [...] Read more.
Streptomyces belongs to the Actinomycetes group of bacteria which are gram-positive non acid-fast bacilli, widely recognised for their potential to produce antimicrobials active against bacterial, mycobacterial, parasitic and fungal infections. They commonly cause cutaneous infections following traumatic inoculation. Visceral infections are relatively rare and limited to immunocompro-mised hosts. We describe a case of Streptomyces pneumonia in a healthy immunocompetent female, who when investigated for voluntary kidney donation, resulted in the isolation of Streptomyces species from bronchial wash cultures. Streptomyces, a potential pathogen in immunocompetent hosts is frequently underdiagnosed. Once isolated, both physicians and microbiologists should pay attention to differentiate true infection from contamination. Full article
733 KiB  
Case Report
Dyspnea in Takayasu Arteritis—An Ordinary Cause with An Extraordinary Link
by Umang Arora, Advait M. Vasavada, Surabhi Vyas and Animesh Ray
Adv. Respir. Med. 2021, 89(1), 63-67; https://doi.org/10.5603/ARM.a2020.0175 - 01 Jul 2020
Viewed by 582
Abstract
Takayasu arteritis (TA) poses a diagnostic challenge as it may have a myriad of clinical presentations. Dyspnea, as an index presentation in TA, may be secondary to the involvement of the aorta, myocardium, and/or the pulmonary vessels, or can present as a manifestation [...] Read more.
Takayasu arteritis (TA) poses a diagnostic challenge as it may have a myriad of clinical presentations. Dyspnea, as an index presentation in TA, may be secondary to the involvement of the aorta, myocardium, and/or the pulmonary vessels, or can present as a manifestation of pulmonary infection with tuberculosis. Significant lymphadenopathy cannot be attributed to TA and serves to point towards a different diagnosis or concomitant infection. Tuberculosis has been associated with TA and has considerable pathogenic and therapeutic implications. We present a case of a young female with extensive intra-thoracic tubercular lymphadenopathy compressing the trachea and right main bronchus resulting in dyspnea. The patient was subsequently found to have active TA and improved after treatment with anti-tubercular therapy and steroids. We review the causes of dyspnea and mediastinal lymphadenopathy in a patient with TA. Full article
194 KiB  
Letter
Cardiology and COVID: A Bidirectional Association!
by Rohit Kumar, Siddharth Raj Yadav, Ashish Goel, Amit Kumar, Pranav Ish and Nitesh Gupta
Adv. Respir. Med. 2021, 89(1), 86-89; https://doi.org/10.5603/ARM.a2020.0169 - 22 Jun 2020
Cited by 1 | Viewed by 376
Abstract
The novel corona virus pandemic has the world in its grip and infection with COVID-19 has proven to be beyond a pulmonary disease [...] Full article
1988 KiB  
Case Report
Primary Pleural Synovial Sarcoma: A Rare Cause of Hemorrhagic Pleural Effusion
by Subodh Kumar, Kashyap Goyal, Ritisha Bhatt, Saloni Bansal and Mayank Mishra
Adv. Respir. Med. 2021, 89(1), 60-62; https://doi.org/10.5603/ARM.a2020.0147 - 11 Jun 2020
Cited by 3 | Viewed by 470
Abstract
Primary pleural synovial sarcoma (PPSS) is a rare malignant pleural tumor comprising < 1% of all primary lung malignancies. Primary pleural mesothelioma (PPM) has many similar features that may cause a diagnostic dilemma due to overlapping clinical and histopathological features. We present the [...] Read more.
Primary pleural synovial sarcoma (PPSS) is a rare malignant pleural tumor comprising < 1% of all primary lung malignancies. Primary pleural mesothelioma (PPM) has many similar features that may cause a diagnostic dilemma due to overlapping clinical and histopathological features. We present the case of a young male with recurrent hemorrhagic pleural effusion without any obvious lung mass who was diagnosed with PPSS. This rare entity must be considered with a high index of suspicion while evaluating pleural tumors. Full article
1138 KiB  
Case Report
Birt-Hogg-Dubé Syndrome—An Unique Case Series
by Parikshit Thakare, Ketaki Utpat, Unnati Desai, Chitra Nayak and Jyotsna M. Joshi
Adv. Respir. Med. 2021, 89(1), 55-59; https://doi.org/10.5603/ARM.a2020.0180 - 16 Dec 2019
Cited by 1 | Viewed by 484
Abstract
Birt-Hogg-Dubé syndrome (BHDS) is an uncommon autosomal dominant syndrome. It is also known as Hornstein–Knickenberg syndrome. It is an inherited disorder culminating in mutations in folliculin coding gene (FLCN). The clinical exhibitions of the syn-drome are multi-systemic, comprising of a constellation of pulmonary, [...] Read more.
Birt-Hogg-Dubé syndrome (BHDS) is an uncommon autosomal dominant syndrome. It is also known as Hornstein–Knickenberg syndrome. It is an inherited disorder culminating in mutations in folliculin coding gene (FLCN). The clinical exhibitions of the syn-drome are multi-systemic, comprising of a constellation of pulmonary, dermatologic and renal system manifestations. The most common presentations include fibrofolliculomas, renal cell carcinomas, lung cysts and spontaneous pneumothorax. The treatment is conservative with regular monitoring of the renal and lung parameters. Fibrofolliculomas may require surgical excision and recurrent events of pneumothorax may warrant pleurodesis. We reported a case series of 2 patients presenting with symptoms of progressive breathlessness along with dermatological manifestations and subsequently showing radiological manifestations of Birt-Hogg-Dubé syndrome in the form of lung cysts. Full article
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