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The Role of Surgical Resection in Unicentric Castleman’s Disease: A Systematic Review

Department of Thoracic Surgery, University College London Hospitals (UCLH), London W1G 8PH, UK
Academic Orthopedic Department, “Papageorgiou” General Hospital, Thessaloniki, Greece
CORE-Center for Orthopedic Research at CIRI-AUTh, Aristotle University Medical School, Thessaloniki, Greece
Author to whom correspondence should be addressed.
Adv. Respir. Med. 2018, 86(1), 36-43;
Original submission received: 13 November 2017 / Revised: 14 February 2018 / Accepted: 14 February 2018 / Published: 28 February 2018


Introduction: Castleman’s disease is a rare benign lymphoproliferative disorder of unknown etiology. The disease occurs in two clinical forms with different prognoses, treatments and symptoms: a unicentric form (UCD), which is solitary, localized, and a multicentric form characterized by generalized lymphadenopathy and systemic symptoms. This article aims to review the current literature to consolidate the evidence surrounding the curative potential of surgical treatment to the unicentric type. Material and methods: A systematic review of English-language literature was performed and databases (Medline, Pubmed, the Cochrane Database and grey literature) were searched to identify articles pertaining to the treatment of unicentric form of Castleman’s disease. Each article was critiqued by two authors using a structured appraisal tool, and stratified according to the level of evidence. Results: After application of inclusion criteria, 14 studies were included. There were no prospective randomized control studies identified. One meta-analysis including 278 patients with UCD reported that resective surgery is safe and should be considered the gold standard for treatment. Seven retrospective studies enhance this standpoint. Radiotherapy (RT) has been used in six studies with controversial results. Conclusions: We conclude that surgical resection appears to be the most effective treatment for Unicentric Castleman’s Disease of the thoracic cavity. Radiotherapy can also achieve clinical response and cure in selected patients.
Keywords: castleman disease; lymphadenopathy; mediastinum; treatment outcome castleman disease; lymphadenopathy; mediastinum; treatment outcome

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MDPI and ACS Style

Mitsos, S.; Stamatopoulos, A.; Patrini, D.; George, R.S.; Lawrence, D.R.; Panagiotopoulos, N. The Role of Surgical Resection in Unicentric Castleman’s Disease: A Systematic Review. Adv. Respir. Med. 2018, 86, 36-43.

AMA Style

Mitsos S, Stamatopoulos A, Patrini D, George RS, Lawrence DR, Panagiotopoulos N. The Role of Surgical Resection in Unicentric Castleman’s Disease: A Systematic Review. Advances in Respiratory Medicine. 2018; 86(1):36-43.

Chicago/Turabian Style

Mitsos, Sofoklis, Alexandros Stamatopoulos, Davide Patrini, Robert S. George, David R. Lawrence, and Nikolaos Panagiotopoulos. 2018. "The Role of Surgical Resection in Unicentric Castleman’s Disease: A Systematic Review" Advances in Respiratory Medicine 86, no. 1: 36-43.

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