Advances in Respiratory Medicine

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Open AccessEditorial

Wyniki konkursu Redaktora Naczelnego czasopisma „Pneumonologia i Alergologia Polska” na najlepszą pracę oryginalną i kazuistyczną opublikowaną lub zakwalifikowaną do druku w okresie od XXXI Zjazdu PTChP w Mikołajkach do XXXII Zjazdu w Wiśle

by Monika Szturmowicz

Adv. Respir. Med. 2012, 80(3), 287; https://doi.org/10.5603/ARM.27593 - 07 May 2012

Viewed by 220

Abstract

Regulamin Konkursu oraz skład Komitetu Naukowegozostały zamieszczone na końcu numeru [...] Full article

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Open AccessReview

Nowości z Kongresu ERS w Amsterdamie 24–28 września 2011

by Paweł Kuca, Elżbieta Puścińska, Adam Szpechciński, Joanna Chorostowska-Wynimko and Monika Szturmowicz

Adv. Respir. Med. 2012, 80(3), 280-286; https://doi.org/10.5603/ARM.27592 - 07 May 2012

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Abstract

W 2011 roku nie zmienił się skład zarządu grupy European Respiratory Society do spraw intensywnej terapii w pneumonologii—jej przewodniczącym jest Paolo Pelosi (Genua, Włochy) [...] Full article

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Open AccessCase Report

The Bleeding into the Emphysematosus Bulla Imitating Lung Tumor

by Mirosław Trzciński, Krystyna Folcik, Barbara Burakowska, Katarzyna Błasińska and Elżbieta Wiatr

Adv. Respir. Med. 2012, 80(3), 275-279; https://doi.org/10.5603/ARM.27588 - 07 May 2012

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Abstract

Bleeding into the lung parenchyma is a rare phenomenon that usually occurs as a result of chest trauma, other causes are anticoagulant therapy, and infections. The following case presents a patient admitted to the hospital due to haemoptysis, which was a symptom of [...] Read more.

Bleeding into the lung parenchyma is a rare phenomenon that usually occurs as a result of chest trauma, other causes are anticoagulant therapy, and infections. The following case presents a patient admitted to the hospital due to haemoptysis, which was a symptom of bleeding into the emphysematosus bulla caused by anticoagulation therapy. The decisive diagnostic examination was chest magnetic resonance. This imaging method allows the precise differentiation of tissues. Using modern imaging techniques can often dispense with invasive diagnostic methods. Full article

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Open AccessCase Report

Malignant Peripheral Nerve Sheath Tumor Associated with Clear Cell Renal Cell Carcinoma—Case Report

by Beata Gryglicka, Irena Węgrzyn-Szkutnik, Janusz Milanowski, Sławomir Mandziuk, Ludmiła Grzybowska-Szatkowska, Dariusz Surdyka, Elżbieta Czekajska-Chehab and Małgorzata Zdunek

Adv. Respir. Med. 2012, 80(3), 269-274; https://doi.org/10.5603/ARM.27587 - 07 May 2012

Cited by 1 | Viewed by 328

Abstract

Malignant peripheral nerve sheath tumor (MPNST) is a rare malignant counterpart to benign neurogenes tumors such as schwannomas and neurofibromas and account for approximately 5–10% of all soft tissue sarcomas. This neoplasm is also referred to older designations as a malignant schwannoma, malignant [...] Read more.

Malignant peripheral nerve sheath tumor (MPNST) is a rare malignant counterpart to benign neurogenes tumors such as schwannomas and neurofibromas and account for approximately 5–10% of all soft tissue sarcomas. This neoplasm is also referred to older designations as a malignant schwannoma, malignant neurilemmoma or neurogenic sarcoma. A patient was a woman of 59 years old with a diagnosed malignant neurilemmoma, treated since 1993. Operated several times and subjected to radiotherapy due to the local recurrence of the tumors located in the soft tissues of the back until 2002; Treated with chemotherapy (doxorubicin) and operated due to lung metastases. The therapy resulted in a total remission that lasted 12 months. In 2004 a new small tumor was diagnosed in the right lung, which had been followed up until 2006. The patient did not give permission to a second surgery, treated with ifosfamide. In 2006 she was operated for renal cell carcinoma of the left kidney. In 2009, due to a following progression of neurilemmoma and a worsening overall condition, she was subsequently treated with a combination of gemcitabine and docetaxel. The treatment resulted in a slight improvement, but was stopped due to complications (pancytopenia). In 2010 another progression of the disease occurred, which resulted in pleural metastases and osteolytic lesions in the vertebrae (Th6 and L2). Full article

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Open AccessReview

Birth Weight as a Factor Determining Lung Function among Healthy Persons and Its Relation with Chronic Pulmonary Disease

by Jerzy Ichnowski, Karolina Lindner, Robert Pawłowicz and Bernard Panaszek

Adv. Respir. Med. 2012, 80(3), 263-268; https://doi.org/10.5603/ARM.27590 - 07 May 2012

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Abstract

Low lung function is associated with increased risk of morbidity and mortality in the population. Lung development seems to be important factor in pathogenesis of respiratory disorders. Airway development is a complex process. Birth weight (BW) is one of perinatal factors which influences [...] Read more.

Low lung function is associated with increased risk of morbidity and mortality in the population. Lung development seems to be important factor in pathogenesis of respiratory disorders. Airway development is a complex process. Birth weight (BW) is one of perinatal factors which influences development of pulmonary system and multiorgan function of the body. Aforementioned relationships are visible especially at first years of life. However, not very many studies have examined the associations between birth weight and lung function in later age then childhood and adolescence. The aim of this review is to discuss relationships between BW and lung function parameters in healthy individuals and patients with lung disease in childhood and adulthood. Full article

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Open AccessReview

The Influence of Treatment with Formoterol, Formoterol with Tiotropium, Formoterol with Inhaled Glucocorticosteroid and Tiotropium on Lung Functions, Tolerance of Exercise and Simple, Morning Everyday Activities in Patients with Chronic Obstructive Pulmonary Disease (COPD)

by Mirosław Szmidt

Adv. Respir. Med. 2012, 80(3), 255-262; https://doi.org/10.5603/ARM.27589 - 07 May 2012

Viewed by 228

Abstract

Bronchodilators—long-acting β₂-adrenergic agonists (formoterol and salmeterol) and a long-acting antimuscarinic drug (tiotropium), are the main drugs applied in symptomatic treatment of COPD. In patients with COPD, dyspnea is frequently associated with simple everyday activities. Two questionnaires have been published recently as [...] Read more.

Bronchodilators—long-acting β₂-adrenergic agonists (formoterol and salmeterol) and a long-acting antimuscarinic drug (tiotropium), are the main drugs applied in symptomatic treatment of COPD. In patients with COPD, dyspnea is frequently associated with simple everyday activities. Two questionnaires have been published recently as a means of assessing the patients’ ability to perform morning activities and symptoms. Dynamic hyperinflation is the pathophysiological disorder responsible for dyspnea and decreased exercise tolerance in COPD. Formoterol is faster than salmeterol in diminishing air-trapping. It has been shown that treatment with formoterol and tiotropium in COPD patients improves FEV₁ , FVC, IC, symptoms score and quality of life in comparison with tiotropium applied alone. Among LABA and inhaled glucocorticosteroids combinations, those containing formoterol have a more beneficial effect on the ability to perform simple morning activities (budesonide/formoterol was better than fluticasone/salmeterol). Beclomethasone/formoterol—400/24 mcg/die, in comparison with fluticasone/salmeterol—500/100 mcg/die significantly reduced air-trapping and dyspnea in COPD patients. The comparison of budesonide/formoterol—400/12 mcg 2 × die with beclomethasone/ /formoterol—200/12 mcg 2 × die has shown similar influence of both combinations on FEV₁ , dyspnea, 6-minute walk test, symptoms score and quality of life. The addition of budesonide and formoterol combination to tiotropium gives further benefits: reduces number of exacerbations, improves FEV₁ , symptoms score and performance of simple morning routines. Doctors should pay more attention to symptoms and limitations in simple activities in the morning and adequately adjust the treatment. Full article

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Open AccessGuidelines

Zalecenia Polskiego Towarzystwa Chorób Płuc Dotyczące Rozpoznawania i Leczenia Przewlekłej Obturacyjnej Choroby Płuc (POChP)

by Dorota Górecka, Ewa Jassem, Władysław Pierzchała and Paweł Śliwiński

Adv. Respir. Med. 2012, 80(3), 220-254; https://doi.org/10.5603/ARM.27591 - 07 May 2012

Cited by 2 | Viewed by 328

Abstract

Pierwsze krajowe Zalecenia Postępowania w Przewlekłej Obturacyjnej Chorobie Płuc (POChP) powstały w 1998 roku z inicjatywy Profesorów Jana Zielińskiego i Józefa Małolepszego oraz Doktora hab [...] Full article

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Open AccessArticle

Trials of Bilevel Positive Airway Pressure—Spontaneous in Patients with Complex Sleep Apnoea

by Tomasz J. Kuźniar, Kamilla Kasibowska-Kuźniar and Thomas Freedom

Adv. Respir. Med. 2012, 80(3), 214-219; https://doi.org/10.5603/ARM.27586 - 07 May 2012

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Abstract

Introduction: Patients with complex sleep apnoea (CompSAS) have obstructive sleep apnoea and experience persistent central apnoeas when exposed to positive airway pressure. Elevated loop gain is one of the postulated mechanisms of CompSAS. We speculated that bilevel positive airway pressure—spontaneous (BPAP-S), by [...] Read more.

Introduction: Patients with complex sleep apnoea (CompSAS) have obstructive sleep apnoea and experience persistent central apnoeas when exposed to positive airway pressure. Elevated loop gain is one of the postulated mechanisms of CompSAS. We speculated that bilevel positive airway pressure—spontaneous (BPAP-S), by producing relative hyperventilation, may more readily produce CompSAS activity than continuous positive airway pressure (CPAP). If found to do so, a trial of BPAP-S might be a simple way of identifying patients with elevated loop gain who are at risk for CompSAS. Materials and methods: Thirty-nine patients with complex sleep apnoea were included in the study. Segments of NREM sleep on CPAP and BPAP-S matched for body position and expiratory airway pressure (“comparison pressure”) were retrospectively analysed. Correlations between clinical and demographic variables and polysomnographic response to CPAP and BPAP-S were sought. Results: There was no difference in any of the polysomnographic indices on CPAP and BPAP-S. In 19 patients the use of CPAP was associated with lower AHI at the comparison pressure; in 20 patients the opposite was true. No clinical variables correlated to the differential response to CPAP vs. BPAP-S. Conclusions: BPAP-S was not more effective than CPAP in stimulating complex sleep apnoea activity. Full article

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Open AccessArticle

Molecular Analysis of Strains from Tuberculosis Patients in Polish Prisons in 2004–2008. Initial Analysis of the Project

by Sylwia Brzezińska, Anna Zabost, Monika Kozińska, Grażyna Janicka-Sobierajska, Zofia Zwolska and Ewa Augustynowicz-Kopeć

Adv. Respir. Med. 2012, 80(3), 209-213; https://doi.org/10.5603/ARM.27585 - 07 May 2012

Cited by 1 | Viewed by 270

Abstract

Introduction: Correctional facilities are recognised “breeding ground” for infectious diseases. As The World Health Organization reported, the incidence of infectious diseases in prison’s population is 10–100 times higher than in general population. The incidence of tuberculosis among correctional inmates in Poland in [...] Read more.

Introduction: Correctional facilities are recognised “breeding ground” for infectious diseases. As The World Health Organization reported, the incidence of infectious diseases in prison’s population is 10–100 times higher than in general population. The incidence of tuberculosis among correctional inmates in Poland in 2008 was 270/100,000, that is around 10 times higher than among non-prisoners. Materials and methods: The study included 57 M. tuberculosis isolates from patients in Polish prisons in 2004–2008 (5% of all diagnosed TB patient in Polish prisons 2004–2008). Primary isolation was performed with Löwenstein-Jensen (L-J) medium, species identification was done with the niacin test and gene probes test. Bacterial DNA was extracted from the L-J medium slants with the cetyltrimethylammonium bromide (CTAB) method. Mycobacterium tuberculosis strains were analyzed with two methods: screening for epidemiological discrimination of M. tuberculosis—spoligotyping and highthroughput—MIRU/VNTR. Results: Isolates that are grouped in clusters (33 isolates) were analyzed by means of MIRU/VNTRs. In MIRU/VNTRs all strains showed different genetic patterns. Most isolates of the prisoners were grouped into two clusters: T1 53 and H3 50. Conclusions: 1. MIRU/VNTR is a high-throughput method. 2. MIRU/VNTR is a promising method to diagnose TB transmission in Polish jails. 3. To identify the probable source of transmission, molecular analysis of strains from patients of the general population is needed. Full article

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Open AccessArticle

Factors Influencing Asthma Course and the Degree of Control in the Patients Assessed with Own Questionnaire and Asthma Control Test (ACT)

by Paulina Krasnodębska, Joanna Hermanowicz-Salamon, Joanna Domagała-Kulawik and Ryszarda Chazan

Adv. Respir. Med. 2012, 80(3), 198-208; https://doi.org/10.5603/ARM.27584 - 07 May 2012

Cited by 2 | Viewed by 292

Abstract

Introduction: Asthma treatment requires control and monitoring. According to Global Initiative For Asthma (GINA) asthma severity is described by degree of control. The aim of the present study was to compare self-patients’ opinions about asthma control with Asthma Control Test (ACT) scores. [...] Read more.

Introduction: Asthma treatment requires control and monitoring. According to Global Initiative For Asthma (GINA) asthma severity is described by degree of control. The aim of the present study was to compare self-patients’ opinions about asthma control with Asthma Control Test (ACT) scores. Furthermore factors associated with asthma control were analyzed in the examined group of patients. Age, BMI, the length and the degree of asthma treatment, concomitant diseases, physical activity, exposition to the tobacco smoke, needs for education and self-control were assessed. Material and methods: The study was based on a 36-point questionnaire that evaluated last two years of asthma duration, the reference data were obtained by objective evaluation with ACT. Fifty three patients, 37 women and 16 men, median age 54 years (24–80 years), from outpatients clinic were enrolled into the study. According to ACT score the patients (pts) were divided into 3 groups: 25 points—well controlled asthma (group 1), 20–24 points—partially controlled asthma (group 2) and less than 20 points—lack of asthma control (group 3). Kruskal-Wallis test and Chi-square test were used to compare the characteristics of subjects in different ACT groups. Pearson’s test was used for assessment of correlation between different parameters. Results: Twenty seven of 53 pts (51%) were treated with low dose of inhaled steroids and long acting beta-agonists (third degree of treatment according to GINA). During last two years the treatment was intensified in 37 pts (70%) due to exacerbation, and 19 of them (36%) were hospitalized in the course of exacerbation. Although 36 out of 53 pts (68%) claimed their asthma was fully controlled, ACT showed full control only in 5/53 (9%) of cases, partial control in 18/53 (34%), lack of control—in 30/53 (57%). Older age (p < 0.05) and longer duration of the disease (p < 0.01) were the factors significantly influencing lack of asthma control. A tendency towards worse asthma control was combined also with overweight and greater number of concomitant diseases (mainly coronary artery disease, diabetes and gastro-esophageal reflux). The presence of influenza vaccinations in medical history was associated with better asthma control (p = 0.05). Conclusions: A discrepancy between subjective assessment of asthma control and ACT score was observed in the examined group of patients. The frequency of asthma exacerbations (according to questionnaire) was describing the degree of asthma control more precisely than self-assessment. Older age and longer disease duration were combined with significantly worse asthma control. Better asthma control was combined with the presence of influenza vaccinations in medical history. Full article

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Open AccessEditorial

Molecular Genotyping Methods in Epidemiological Investigations of TB Infections

by Anna Brzostek and Jarosław Dziadek

Adv. Respir. Med. 2012, 80(3), 193-197; https://doi.org/10.5603/ARM.27583 - 07 May 2012

Cited by 1 | Viewed by 229

Abstract

Gruźlica pozostaje jednym z najistotniejszych problemów zdrowotnych na świecie [...] Full article

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Adv. Respir. Med., Volume 80, Issue 3 (May 2012) – 11 articles , Pages 193-287

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