Advances in Respiratory Medicine

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Open AccessEditorial

Kartki z historii (część 2)

by Jan Zieliński and Emil Wojda

Adv. Respir. Med. 2008, 76(5), 410-414; https://doi.org/10.5603/ARM.27883 - 17 Sep 2008

Viewed by 216

Abstract

W 2007 r. upłynęło 130 lat od otwarcia Szpitala Wolskiego przy ulicy Płockiej 26 w Warszawie [...] Full article

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Open AccessEditorial

Wspomnienie o Prof. Danucie Szymańskiej-Bajerskiej (1923–2008)

by Renata Langfort

Adv. Respir. Med. 2008, 76(5), 407-409; https://doi.org/10.5603/ARM.27882 - 17 Sep 2008

Viewed by 233

Abstract

W dniu 6 kwietnia 2008 r. zmarła Profesor Danuta Szymańska-Bajerska [...] Full article

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Open AccessCase Report

Invasive Aspergillosis of the Paranasal Sinuses, Lung and Brain

by Krzysztof Kędziora, Jan Marek Słomiński, Katarzyna Gil, Maria Porzezińska and Agnieszka Gorzewska

Adv. Respir. Med. 2008, 76(5), 400-406; https://doi.org/10.5603/ARM.27878 - 17 Sep 2008

Cited by 1 | Viewed by 237

Abstract

A case of invasive aspergillosis (IA) of paranasal sinuses, lung and brain with a fulminant fatal outcome is reported. A 43-year-old man with a history of skin carcinoma of the nasal region and a course of systemic corticosteroids, presented with symptoms of lung [...] Read more.

A case of invasive aspergillosis (IA) of paranasal sinuses, lung and brain with a fulminant fatal outcome is reported. A 43-year-old man with a history of skin carcinoma of the nasal region and a course of systemic corticosteroids, presented with symptoms of lung infection. Aspergillus fumigatus was cultured from respiratory and nasal samples. Erosion of adjacent bones of the nasal cavity was acknowledged, but no sinus surgery was performed. A computed tomography of the thorax showed thick-walled cavities of different sizes with air and scarce fluid levels in both lungs. Treatment with voriconazole was administered. The patient deteriorated in the ensuing 2 weeks because central nervous system involvement was observed. No aggressive surgical resection was performed and the patient died 2 weeks later. IA was not confirmed by histopathology because no necropsy was performed. Full article

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Open AccessCase Report

Adult Form of Pompe Disease

by Bożena Ziółkowska-Graca, Aleksander Kania, Grażyna Zwolińska and Ewa Niżankowska-Mogilnicka

Adv. Respir. Med. 2008, 76(5), 396-399; https://doi.org/10.5603/ARM.27877 - 17 Sep 2008

Viewed by 266

Abstract

Pompe disease (glycogen-storage disease type II) is an autosomal recessive disorder caused by a deficiency of lysosomal acid α-glucosidase (GAA), leading to the accumulation of glycogen in the lysosomes primarily in muscle cells. In the adult form of the disease, proximal muscle [...] Read more.

Pompe disease (glycogen-storage disease type II) is an autosomal recessive disorder caused by a deficiency of lysosomal acid α-glucosidase (GAA), leading to the accumulation of glycogen in the lysosomes primarily in muscle cells. In the adult form of the disease, proximal muscle weakness is noted and muscle volume is decreased. The infantile form is usually fatal. In the adult form of the disease the prognosis is relatively good. Muscle weakness may, however, interfere with normal daily activities, and respiratory insufficiency may be associated with obstructive sleep apnea. Death usually results from respiratory failure. Effective specific treatment is not available. Enzyme replacement therapy with recombinant human GAA (rh-GAA) still remains a research area. We report the case of a 24-year-old student admitted to the Department of Pulmonary Diseases because of severe respiratory insufficiency. Clinical symptoms such as dyspnea, muscular weakness and increased daytime sleepiness had been progressing for 2 years. Clinical examination and increased blood levels of CK suggested muscle pathology. Histopathological analysis of muscle biopsy, performed under electron microscope, confirmed the presence of vacuoles containing glycogen. Specific enzymatic activity of α-glucosidase was analyzed confirming Pompe disease. The only effective method to treat respiratory insufficiency was bi-level positive pressure ventilation. Respiratory rehabilitation was instituted and is still being continued by the patient at home. A high-protein, low-sugar diet was proposed for the patient. Because of poliglobulia, low molecular weight heparin was prescribed. The patient is eligible for experimental replacement therapy with rh-GAA. Full article

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Open AccessGuidelines

Wskazówki metodologiczne Polskiego Towarzystwa Chorób Płuc odnośnie do wykonywania i oceny plwociny indukowanej

by Beata Chmielowicz, Andrzej Obojski, Adam Barczyk, Ewa Sozańska, Zdzisława Kycler, Urszula Demkow and Joanna Domagała-Kulawik

Adv. Respir. Med. 2008, 76(5), 378-394; https://doi.org/10.5603/ARM.27884 - 17 Sep 2008

Cited by 3 | Viewed by 240

Abstract

W miarę rozwoju metod diagnostycznych pojawia się potrzeba tworzenia precyzyjnych zasad wykonywania badań [...] Full article

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Open AccessReview

Nadwrażliwość na aspirynę i inne niesteroidowe leki przeciwzapalne—Mechanizmy, diagnostyka, terapia

by Maciej Kupczyk and Piotr Kuna

Adv. Respir. Med. 2008, 76(5), 366-377; https://doi.org/10.5603/ARM.27881 - 17 Sep 2008

Viewed by 344

Abstract

Pojęcie nadwrażliwości na aspirynę obejmuje szereg niepożądanych objawów ze strony górnych i dolnych dróg oddechowych, skóry oraz przewodu pokarmowego pojawiających się po zażyciu aspiryny i innych niesteroidowych leków przeciwzapalnych. Astma oskrzelowa z nadwrażliwością na aspirynę lub inne niesteroidowe leki przeciwzapalne występuje u około [...] Read more.

Pojęcie nadwrażliwości na aspirynę obejmuje szereg niepożądanych objawów ze strony górnych i dolnych dróg oddechowych, skóry oraz przewodu pokarmowego pojawiających się po zażyciu aspiryny i innych niesteroidowych leków przeciwzapalnych. Astma oskrzelowa z nadwrażliwością na aspirynę lub inne niesteroidowe leki przeciwzapalne występuje u około 10% dorosłych pacjentów z astmą. U osób nadwrażliwych na aspirynę zahamowanie syntezy prostaglandyny E₂ (PGE₂) z jednoczesnym wzrostem produkcji leukotrienów cysteinylowych (Cys-LT) wydaje się leżeć u podłoża patomechanizmów choroby. Złotym standardem diagnostyki nadwrażliwości na aspirynę są próby ekspozycji kontrolowane placebo. Full article

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Open AccessReview

Występowanie oraz patogeneza zespołu jadłowstrętu i wyniszczenia nowotworowego w raku płuca

by Monika Kosacka, Bożena Weryńska, Marcin Gołecki, Renata Jankowska and Ewa Passowicz-Muszyńska

Adv. Respir. Med. 2008, 76(5), 360-365; https://doi.org/10.5603/ARM.27880 - 17 Sep 2008

Viewed by 252

Abstract

Zespół jadłowstrętu i wyniszczenia nowotworowego (CACS) stanowi częste i poważne powikłanie choroby nowotworowej. Występuje u 30–80% chorych. W chwili rozpoznania raka płuca nie stanowi jeszcze poważnego problemu, ale spadek masy ciała postępuje wraz z rozwojem choroby nowotworowej. Zespół ten charakteryzuje się jadłowstrętem, utratą [...] Read more.

Zespół jadłowstrętu i wyniszczenia nowotworowego (CACS) stanowi częste i poważne powikłanie choroby nowotworowej. Występuje u 30–80% chorych. W chwili rozpoznania raka płuca nie stanowi jeszcze poważnego problemu, ale spadek masy ciała postępuje wraz z rozwojem choroby nowotworowej. Zespół ten charakteryzuje się jadłowstrętem, utratą masy ciała, osłabieniem, upośledzeniem funkcji układu immunologicznego oraz zaburzeniami metabolicznymi. Utrata masy ciała w warunkach prawidłowych pobudza apetyt i przyjmowanie pokarmu—zaburzenie tego mechanizmu jest jedną z cech CACS. Utrata masy ciała w CACS różni się od obserwowanej w przypadku głodzenia. Wiele badań koncentruje się na ocenie roli cytokin w rozwoju CACS. Przedmiotem badań są głównie TNF-α, IL-1 i IL-6. W wielu doniesieniach potwierdzono ich rolę w rozwoju CACS, nie brakuje też jednak wątpliwości, czy zmiany obserwowane w ich stężeniach są przyczyną, czy raczej tylko skutkiem. Część najnowszych badań koncentruje się na roli czynnika jądrowego kappa B i zapobieganiu rozwojowi CACS przez zastosowanie jego inhibitorów. Zespół jadłowstrętu i wyniszczenia nowotworowego jest niekorzystnym czynnikiem prognostycznym oraz zwiększa ryzyko powikłań leczenia onkologicznego. Full article

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Open AccessReview

Bacterial Immunostimulants—Mechanism of Action and Clinical Application in Respiratory Diseases

by Adriana Roży and Joanna Chorostowska-Wynimko

Adv. Respir. Med. 2008, 76(5), 353-359; https://doi.org/10.5603/ARM.27879 - 17 Sep 2008

Cited by 16 | Viewed by 447

Abstract

Immunity towards bacteria might be achieved as a result of natural processes following infection, or as a consequence of medical intervention including vaccination, administration of immunoglobulins or therapy with immunostimulants derived from bacteria. Bacterial immunostimulants (ISs) containing bacterial lysate (OM-85 BV, LW 50020) [...] Read more.

Immunity towards bacteria might be achieved as a result of natural processes following infection, or as a consequence of medical intervention including vaccination, administration of immunoglobulins or therapy with immunostimulants derived from bacteria. Bacterial immunostimulants (ISs) containing bacterial lysate (OM-85 BV, LW 50020) or components of bacterial cells (ribosomal extracts) were shown to induce a non-specific response (i.e., intensification of phagocytosis) but also to orchestrate both cellular (B, T cell stimulation) and humoral responses (antibodies and proinflammatory cytokines production). Therefore, the duality of their immunomodulatory activity mimics or, to a certain extent, repeats the immune response evoked by the intrusion of a pathogen into the human body, which is initially non-specific, but subsequently becomes specific. However, their clinical efficacy in the prevention of respiratory tract infection (RTI) is still debated. This article reviews their mechanism of action, as well as the available clinical data, discussing the pros and cons of their use in the prevention of RITs in children and adults. Full article

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Open AccessArticle

Alergiczny nieżyt nosa—Problem epidemiologiczny, ekonomiczny i społeczny XXI wieku

by Ryszard Rutkowski, Bożena Kosztyła-Hojna and Joanna Rutkowska

Adv. Respir. Med. 2008, 76(5), 348-352; https://doi.org/10.5603/ARM.27876 - 17 Sep 2008

Viewed by 320

Abstract

Nieżyt nosa może być spowodowany przez różnorodne czynniki alergiczne i niealergiczne. Powstaje również w wyniku ich jednoczesnego oddziaływania na błonę śluzową nosa. Alergiczny nieżyt nosa występuje u około 10–25% populacji ludzkiej, co powoduje, że jest uznawany za najczęstszą alergiczną chorobę świata. Spośród dzieci [...] Read more.

Nieżyt nosa może być spowodowany przez różnorodne czynniki alergiczne i niealergiczne. Powstaje również w wyniku ich jednoczesnego oddziaływania na błonę śluzową nosa. Alergiczny nieżyt nosa występuje u około 10–25% populacji ludzkiej, co powoduje, że jest uznawany za najczęstszą alergiczną chorobę świata. Spośród dzieci z alergicznym nieżytem nosa aż 30% choruje na sezonowy nieżyt nosa, a tylko u 10% stwierdza się postać całoroczną nieżytu. W Polsce, w grupie badanej przez Bręborowicza i wsp., alergiczny nieżyt nosa obserwowano u 16.7% dzieci w wieku 6–7 lat, natomiast w badaniach Emeryka i wsp. całoroczny nieżyt występował u 3.6%, a sezonowy u 6.2% dzieci w wieku 8–15 lat. Alergiczny nieżyt nosa—podobnie do innych chorób—powoduje określone koszty bezpośrednie, pośrednie i ukryte. W 2002 roku w Stanach Zjednoczonych koszty bezpośrednie wynosiły około 4.195 miliarda dolarów, a koszty pośrednie osiągnęły wartość około 665 milionów dolarów, co w sumie dawało kwotę 4.863 miliarda dolarów. Alergiczny nieżyt nosa często występuje z licznymi chorobami układu oddechowego, co istotnie zwiększa koszty leczenia ponoszone przez chorego oraz straty finansowe państwa. Rzutuje także niekorzystnie na sytuację społeczną chorych, istotnie pogarszając jakość życia pacjentów i ich rodzin. Full article

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Open AccessArticle

Metabolic Abnormalities in Obstructive Sleep Apnea Patients

by Justyna Czerniawska, Przemysław Bieleń, Robert Pływaczewski, Monika Czystowska, Damian Korzybski, Paweł Śliwiński and Dorota Górecka

Adv. Respir. Med. 2008, 76(5), 340-347; https://doi.org/10.5603/ARM.27875 - 17 Sep 2008

Cited by 2 | Viewed by 376

Abstract

Introduction: OSA is a well-recognized risk factor of cardiovascular disorders and is related to metabolic syndrome. The aim of this study was to evaluate the effect of BMI and AHI/RDI on metabolic disturbances in patients suspected of OSA. Material and methods: Ninety-nine patients [...] Read more.

Introduction: OSA is a well-recognized risk factor of cardiovascular disorders and is related to metabolic syndrome. The aim of this study was to evaluate the effect of BMI and AHI/RDI on metabolic disturbances in patients suspected of OSA. Material and methods: Ninety-nine patients referred with suspected OSA underwent standard polysomnography or limited sleep study. AHI/RDI ≥ 10/h was considered relevant for OSA diagnosis. Subjects with AHI/RDI < 10 were considered as controls. We assessed apnea-hypopnea index or respiratory disturbances index (AHI/RDI), Epworth sleepiness scale (ESS), body mass index (BMI), C-reactive protein (CRP, mg/L), glycosylated haemoglobin (HbA1c, %), fasting serum total cholesterol, HDL-, LDL-cholesterol, triglycerides (TG), glucose (G), insulin (INS, IU/mL) and HOMA index. Results: Data are presented as mean ± SD or median (interquartile range) for parametric and nonparametric data respectively. Twenty-two patients were included as controls (age 51.8 ± 10 vs. 55 ± 11 in OSA; p = NS). AHI/RDI in the OSA group was 23 (16–31.3) and 7 (3.8–8.1) in controls (p < 0.001). BMI in OSA 32.2 ± 5.8 vs. 30.4 ± 4.6 in controls (p = NS). Patients with OSA had higher TG (160 ± 75.9 vs. 130.2 ± 51.9 mg/dL, p = 0.046), G (5.04 ± 0.6 vs. 4.47 ± 0.6, p = 0.0037), HOMA (2.31 ± 1.5 vs. 1.85 ± 1.7, p = 0.046). G correlated best with AHI/RDI (p < 0.001, r = 0.41). Significant differences were observed in OSA patients between obese (51 pts, BMI 35.2 ± 4.8) and non-obese (26 pts, BMI 26.61 ± 1.9) pts in: HDL-cholesterol (50.8 ± 13.2 vs. 60.9 ± 18.4 mg/dL; p = 0.02), TG (178.7 ± 69.9 vs. 124 ± 75.3 mg/dL, p < 0.001), G (5.15 ± 0.7 vs. 4.8 ± 0.5 mmol/L, p = 0.01), INS (11.7 ± 5.9 vs. 6.57 ± 4.7, p < 0.001), HOMA (2.7 ± 1.4 vs. 1.4 ± 1.2, p < 0.001), HbA1c (5.89 ± 0.9 vs. 5.4 ± 0.8, p = 0.03), CRP (2.2 ± 2.9 vs. 1.09 ± 1.2, p = 0.01). Conclusions: Our findings support the results of previous studies showing the influence of OSA alone on metabolic disturbances. However, BMI has major impact on metabolic variables. Full article

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Open AccessArticle

Organizing Pneumonia—Clarithromycin Treatment

by Elżbieta Radzikowska, Elżbieta Wiatr, Dariusz Gawryluk, Renata Langfort, Iwona Bestry, Mariusz Chabowski and Kazimierz Roszkowski

Adv. Respir. Med. 2008, 76(5), 334-339; https://doi.org/10.5603/ARM.27874 - 17 Sep 2008

Cited by 4 | Viewed by 301

Abstract

Introduction: Organizing pneumonia (OP) is a rare syndrome that has been associated with a variety of underlying factors including infections, collagen vascular diseases, toxic fumes, cancer, drugs and radiotherapy. A cryptogenic form is also observed. OP is a curable disease in the most [...] Read more.

Introduction: Organizing pneumonia (OP) is a rare syndrome that has been associated with a variety of underlying factors including infections, collagen vascular diseases, toxic fumes, cancer, drugs and radiotherapy. A cryptogenic form is also observed. OP is a curable disease in the most cases. Steroids are the standard therapy, but other treatment regimens have been used as well. Material and methods: In the period from 1999 to 2005, 9 women and 3 men (age range 44–71 years) with OP were selected for the study. There were 9 non-smokers, 2 smokers and 1 ex-smoker. Open lung biopsy was performed in 5 patients, and in 7 patients diagnosis was established on the basis of transbronchial lung biopsy. Results: Dyspnoea (100%), cough (100%), weakness (100%), fever (83%), loss of weight (83%), sweats (33%) and chest pain (8%) were the most frequently noticed symptoms. Radiographically, all patients had bilateral consolidations with areas of ground glass attenuations. A migratory pattern of these lesions was observed in 9 (75%) patients. In all patients clarithromycin (CLA) in a dose 0.5 g b.i.d was administered. Nine (75%) patients were successfully treated. Complete clinical and radiological remission was obtained after 3 months of CLA therapy in 7 and a partial response in an additional 2 patients, in whom treatment was prolonged to 4 months. During the first month of CLA treatment 3 patients did not respond to the therapy, and prednisone was introduced. The observation period ranged from 30 to 90 months (mean 42 months). Adverse reaction to CLA and relapse did not occur. Conclusions: OP can be treated with clarithromycin. It may be an alternative treatment, particularly for patients in good clinical status and in whom the probability of adverse events in the course of corticotherapy is high. Full article

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Open AccessArticle

Analysis of Nutritional Status Disturbances in Patients with Chronic Obstructive Pulmonary Disease

by Barbara Kuźnar-Kamińska, Halina Batura-Gabryel, Beata Brajer and Jacek Kamiński

Adv. Respir. Med. 2008, 76(5), 327-333; https://doi.org/10.5603/ARM.27873 - 17 Sep 2008

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Abstract

Introduction: Among the most common extrapulmonary manifestations of COPD are nutritional status disorders. The specific loss of weight, called cachexia, characterized by loss of lean body mass in some COPD patients is observed. The aim of the study was the quantitative and qualitative [...] Read more.

Introduction: Among the most common extrapulmonary manifestations of COPD are nutritional status disorders. The specific loss of weight, called cachexia, characterized by loss of lean body mass in some COPD patients is observed. The aim of the study was the quantitative and qualitative analysis of COPD patients’ nutritional status disturbances. Material and methods: Fifty-five patients in different stages of COPD—43 males and 12 females (mean age 62.31 ± 11.08) and 32 subjects from a control group (mean age 57.43 ± 8.79) participated in the study. In both groups nutritional status was assessed using different indicators such as PIBW—percentage of ideal body weight, BMI—body mass index, FFMI—fat-free mass index and FMI—fat mass index. Results: Malnutrition measured by PIBW, BMI, BMI percentiles, and FFMI was observed in 5.45%, 3.64%, 3.64% and 18.18% of COPD patients, respectively, and in the control group 3.12%, 0%, 3.12% and 3.12%, respectively. The BMI mean value did not differ significantly between groups. It was confirmed that cachexia assessed by FFMI occured more frequently in COPD patients than in the control group—19.05 kg/m² vs. 20.55 kg/m² (p = 0.04). Conclusions: 1. Nutritional status disorders pose a serious problem, which concerns about 1/5 of the COPD population. 2. It is necessary to perform quantitative analysis of nutritional status (assessment of lean and fat mass) because indicators of body mass (PIBW, BMI) are not sufficient for cachexia detection. 3. Having normal body mass does not exclude the possibility of nutritional status disorders in COPD patients. Full article

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Open AccessArticle

Assessment of Acute Phase Proteins as Prognostic Factors in Patients Surgically Treated for Non-Small Cell Lung Cancer

by Mariusz Kasprzyk, Wojciech Dyszkiewicz, Damian Zwaruń, Kinga Leśniewska and Krzysztof Wiktorowicz

Adv. Respir. Med. 2008, 76(5), 321-326; https://doi.org/10.5603/ARM.27872 - 17 Sep 2008

Cited by 2 | Viewed by 245

Abstract

Introduction: The aim of the study was to assess quantitative acute phase protein (APP) level changes in patients with non-small cell lung cancer (NSCLC) subjected to radical resections, as well as their influence on long-term survival. We analysed the correlation between quantitative APP [...] Read more.

Introduction: The aim of the study was to assess quantitative acute phase protein (APP) level changes in patients with non-small cell lung cancer (NSCLC) subjected to radical resections, as well as their influence on long-term survival. We analysed the correlation between quantitative APP changes and the histological type of the carcinoma, as well as the TNM stage and grade. Materials and methods: The study group comprised 46 patients subjected to surgical treatment of NSCLC during the period between 2003 and 2004. Average patient age amounted to 61 years (ranging between 45 and 77 years). The most frequent histological types of cancer were: squamous cell lung cancer (24 patients) and adenocarcinoma (17 patients). The majority of patients were diagnosed with stage II B (15 patients) and III A (14 patients). We evaluated the levels of the following APP: C-reactive protein (CRP), α1-acid glycoprotein (AGP), α1-antichymotrypsin (ACT), α1-antitrypsin (AT), α2-macroglobulin (M), ceruloplasmin (Cp), haptoglobin (Hp), and transferrin (Tf) by means of rocket immunoelectrophoresis (Laurell’s method). Results: The level of AT was significantly higher in patients with adenocarcinoma, as compared to other histological types of cancer. In the case of patients with squamous cell lung cancer, significantly higher M and Cp levels were observed. We found no correlation between the APP level and tumour grading. The levels of five APP: CRP, AGP, ACT, M and Cp were significantly higher in the group of patients with T3 or T4 category, while N1 or N2 patients presented with significantly higher concentrations of AT, CRP and Hp. Multivariate analysis confirmed the influence of the following factors on long-term survival: N stage, histological type of cancer and preoperative serum levels of AGP and Hp. Conclusions: The serum concentration of some acute phase proteins can correlate with the more aggressive clinical course of non-small cell lung cancer (NSCLC). Patients with adenocarcinoma and local lymph node metastases present with significantly higher levels of AT. Thus, it seems that the elevated preoperative levels of AGP and Hp might unfavourably influence long-term survival. The above-mentioned proteins might prove useful as prognostic factors when assessing the risk of neoplastic recurrence following surgical management. Full article

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Open AccessArticle

Influence of Neck Circumference and Body Mass Index on Obstructive Sleep Apnoea Severity in Males

by Robert Pływaczewski, Przemysław Bieleń, Michał Bednarek, Luiza Jonczak, Dorota Górecka and Paweł Śliwiński

Adv. Respir. Med. 2008, 76(5), 313-320; https://doi.org/10.5603/ARM.27871 - 17 Sep 2008

Cited by 7 | Viewed by 287

Abstract

Introduction: Obesity and male gender are the main risk factors for the development of obstructive sleep apnoea (OSA); however, some epidemiological data has shown that neck circumference (NC) ≥ 43 cm is a better predictor of obstructive event frequency than body mass index [...] Read more.

Introduction: Obesity and male gender are the main risk factors for the development of obstructive sleep apnoea (OSA); however, some epidemiological data has shown that neck circumference (NC) ≥ 43 cm is a better predictor of obstructive event frequency than body mass index (BMI). The aim of this study was to assess the relation between NC and BMI on OSA severity in males. Material and methods: The subjects completed a sleep questionnaire and Epworth sleepiness scale before the sleep study (full polysomnography or PolyMesam study). We studied 133 consecutive males with confirmed OSA (AHI/RDI > 10, Epworth score > 9 points). Chest X-ray, spirometry, arterial blood gases, ECG, blood morphology and biochemistry were performed during treatment trial with autoCPAP. Results: Subjects presented with obesity—BMI = 35.8 ± 6.1 kg/m², NC = 46 ± 3.4 cm and severe disease—AHI/RDI = 45.3 ± 23.6. Mean age was 52.7 ± 11.3 years. The majority of subjects had NC ≥ 43 cm (116 pts, 87.2%—group 1), 17 pts (12.8%—group 2) had NC < 43 cm had 17 pts. Comparison of both groups showed significant differences only for BMI (gr. 1—36.8 ± 5.7, gr. 2—28.6 ± 3.7; p < 0.0001). Linear regression analysis revealed significant correlation between NC and AHI/RDI (R² = 0.07, r = 0.26; p = 0.003); however, the correlation between BMI and AHI/RDI was stronger (R² = 0.14, r = 0.37; p < 0.0001). In multiple linear regression analysis we found significant correlation between AHI/RDI and age (β = –0.31, p = 0.003) and BMI (β = 0.34, p = 0.02). Conclusions: The strongest correlation between AHI/RDI, younger age and BMI was found in males with OSA. Correlation between neck circumference and AHI/RDI was significant but less when compared to BMI. Full article

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Open AccessEditorial

Zespół Anoreksja—Kacheksja w Przebiegu Raka Płuca

by Elżbieta Radzikowska

Adv. Respir. Med. 2008, 76(5), 311-312; https://doi.org/10.5603/ARM.27870 - 17 Sep 2008

Viewed by 308

Abstract

Rak płuca (RP) stanowi jedno z największych wyzwań opieki zdrowotnej XXI wieku [...] Full article

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Adv. Respir. Med., Volume 76, Issue 5 (September 2008) – 15 articles , Pages 311-414

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