The aim of our study was to assess serum uric acid (UA) in a large group of females with OSA before treatment (normal UA value is from 2.4 to 5.7 mg/dL). We studied 105 consecutive females (73.3% without estrogen activity), mean age 58.5 ± 9.9 years, mean BMI = 33.3 ± 8.2 kg/m
2 with OSA (mean AHI = 35.6 ± 21.5, mean overnight SaO
2 = 89 ± 6.3%). We divided patients in two groups: 1st with hyperuricaemia-UA > 5.7 mg/dL (53 pts, 50.5%) and 2nd with normouricaemia-UA ≤ 5.7 mg/dL (52 pts, 49.5%). Concentartion of serum uric acid was similar in females with and without estrogen activity. Subjects with hyperuricaemia had significantly higher BMI (
p < 0.001), lower mean SaO
2 (
p < 0.01) and spent more time in desaturation below 90% (
p < 0.01). This group had lower FVC, FEV
1 i PaO
2 (
p < 0.001), higher PaCO
2 (
p < 0.01) and morning glucose (
p < 0.001). Females with OSA and hyperuricaemia presented higher prevalence of systemic hypertension (
p < 0.001 ), coronary artery disease (
p < 0.05), diabetes (not significant) and COPD (
p < 0.05). Multiple regression analysis revealed relation between serum uric acid, BMI and arterial hypertension. Conclusions: Hyperuricaemia is frequent in females with OSA. Increased UA levels were related especially to obesity and arterial hypertension. Lower: overnight SaO
2, FVC, FEV
1, PaO
2 and higher glucose concentration and PaCO
2 may play role in developing of hyperuricaemia.
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