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Abstract

Viburnum opulus L. Fruit Extracts Protect Human Neuroblastoma SH-SY5Y Cells against Hydrogen Peroxide-Induced Cytotoxicity †

1
Department of Pharmacognosy, Faculty of Pharmacy, Erciyes University, 38039 Kayseri, Turkey
2
Department of Pharmacology, Faculty of Pharmacy, Erciyes University, 38039 Kayseri, Turkey
*
Author to whom correspondence should be addressed.
Presented at the 3rd International conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 18–20 December 2019.
Proceedings 2019, 40(1), 5; https://doi.org/10.3390/proceedings2019040005
Published: 25 December 2019

Abstract

:
Viburnum L., is one of the most diverse genera of Caprifoliaceae family. There are 4 species of this genus in Turkey. One of them is Viburnum opulus L. The fruits of V. opulus have been used as an antidiabetic in Turkish folk medicine and a traditional drink named “gilaburu” in Middle Anatolia. Oxidative stress is involved in the cell degenerative changes in the pathogenesis of a wide variety of human chronic diseases, such as cancer. Some of the studies carried out on the V. opulus extracts revealed the presence of phenolic acids, flavonoids, hydroxybenzoic acids, tannins, coumarins, cathechols, iridoid glycosides, antocyanins, and some others. Most of these polyphenols have various biological activities, including antioxidant, cancer chemopreventive, and anticancer activities. This study aimed to assess the in vitro antioxidant properties of the ethanol extract (VOE), decoction (VOD) and fruit juice (VOFJ) from the fruits of V. opulus against hydrogen peroxide (H2O2)-induced oxidative stress in human SH-SY5Y neuronal cells. Our study revealed that the VOE, VOD and VOFJ provided neuroprotection against H2O2-induced oxidative stress. In conclusion, VOE, VOD and VOFJ can be used as a functional dietary ingredient that might help in reducing health problems associated with various oxidative stress insults.

Acknowledgments

This research is supported by TÜBİTAK (The Scientific and Technological Research Council of Turkey); Project No: 2209A (Research Project Support Programme for Undergraduate Students).
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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MDPI and ACS Style

Paşayeva, L.; Arslan, A.K.K.; Kararenk, A.C. Viburnum opulus L. Fruit Extracts Protect Human Neuroblastoma SH-SY5Y Cells against Hydrogen Peroxide-Induced Cytotoxicity. Proceedings 2019, 40, 5. https://doi.org/10.3390/proceedings2019040005

AMA Style

Paşayeva L, Arslan AKK, Kararenk AC. Viburnum opulus L. Fruit Extracts Protect Human Neuroblastoma SH-SY5Y Cells against Hydrogen Peroxide-Induced Cytotoxicity. Proceedings. 2019; 40(1):5. https://doi.org/10.3390/proceedings2019040005

Chicago/Turabian Style

Paşayeva, Leyla, Ayşe Kübra Karaboğa Arslan, and Ayşe Cemre Kararenk. 2019. "Viburnum opulus L. Fruit Extracts Protect Human Neuroblastoma SH-SY5Y Cells against Hydrogen Peroxide-Induced Cytotoxicity" Proceedings 40, no. 1: 5. https://doi.org/10.3390/proceedings2019040005

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