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Opinion

Secreted Protein Acidic and Rich in Cysteine (SPARC) to Manage Coronavirus Disease-2019 (COVID-19) Pandemic and the Post-COVID-19 Health Crisis

1
Department of Molecular Medicine, Faculty of Medicine, Laval University, Québec, QC G1V 0A6, Canada
2
Functional Genomics Laboratory, Endocrinology and Nephrology Axis, CHU de Québec-Université Laval Research Center, Québec, QC G1V 4G2, Canada
*
Author to whom correspondence should be addressed.
Medicines 2023, 10(5), 32; https://doi.org/10.3390/medicines10050032
Submission received: 3 March 2023 / Revised: 19 April 2023 / Accepted: 12 May 2023 / Published: 16 May 2023

Abstract

:
Coronavirus disease-2019 (COVID-19) has had and will have impacts on public health and health system expenses. Indeed, not only it has led to high numbers of confirmed COVID-19 cases and hospitalizations, but its consequences will remain even after the end of the COVID-19 crisis. Therefore, therapeutic options are required to both tackle the COVID-19 crisis and manage its consequences during the post COVID-19 era. Secreted protein acidic and rich in cysteine (SPARC) is a biomolecule that is associated with various properties and functions that situate it as a candidate which may be used to prevent, treat and manage COVID-19 as well as the post-COVID-19-era health problems. This paper highlights how SPARC could be of such therapeutic use.

Coronavirus disease-2019 (COVID-19) can been considered as the greatest health crisis which humanity has faced since the Spanish flu pandemic [1] in terms of the number of deaths. In addition, the resulting saturation of the health system and socio-economic consequences are also key impacts of the COVID-19 crisis [2,3] resulting from the applied measures aiming to limit COVID-19’s spread. Ironically, such measures (including confinement [4,5,6] and work-from-home policies [7,8,9,10])) have negative impacts on health and could even increase vulnerability to COVID-19 by promoting COVID-19 risk factors (obesity [11,12], physical inactivity [13,14], unhealthy diet, etc.) within the population. Indeed, one of the interesting characteristics of this context is the fact that not only do these risk factors increase COVID-19’s infectiousness and severity, but the measures applied by governments and health authorities to limit COVID-19’s spread also worsen these risk factors. For instance, individuals are confined at home and develop a new lifestyle [15,16], have reduced physical activity, tend towards sedentariness (beyond physical inactivity [17]), and work from home (cognitive work) [18], which can induce glycemic instability [19], cause individuals to consume more food (quantity), consume more junk food (poor quality), have reduced social interactions and less social activities and develop mental health (risk of psychiatric illness) problems [20,21,22,23,24]. All these elements can impact the metabolic profile, diet behavior and obesity development. They can also lead to smoking, alcohol consumption and drug use, which are additional risk factors for various health problems. Such mechanistic links extend in multiple directions. Whereas they can impact obesity development [25] and diet behavior (emotional eating) [26,27,28,29,30], diet [31] and obesity [32] can also affect mental health, including self-esteem [33]. Importantly, the different diseases that can develop with obesity (as their risk factor), such as coronary heart disease, type 2 diabetes, liver disease and cancers [34,35,36,37,38,39,40,41,42,43], will further place individuals at risk of developing severe forms of COVID-19 [44,45,46].
Moreover, physical inactivity is associated with impaired immunity [47] and increased systemic inflammation [48], which are more important to highlight during this ongoing COVID-19 crisis [47]. As illustrated by the examples given above, obesity increases susceptibility to COVID-19, which can be corrected through exercise and a controlled diet [49,50,51,52,53,54,55,56,57,58]. However, at the same time, the COVID-19-crisis-related measures taken by different governments are oriented towards inducing a novel socioeconomic environment. This environment will lead to obesity by increasing food intake, physical inactivity and even reduced food quality, since the economic situation renders healthy food hardly affordable. In conclusion, to address such factors that increase susceptibility to, and risk of, COVID-19, beyond targeting these factors, we must also think of innovative solutions to modify or change the measures taken to limit COVID-19’s impacts in a way that could reduce obesity-favoring COVID-19-crisis-related factors.
Among the most noticeable COVID-19-severity-determining factors is inflammation. Indeed, the severity of COVID-19 depends on the inflammatory reactions that develop as a response to the virus. Based on what is known about the inflammatory storm in severe COVID-19 cases [59,60,61,62,63], we can distinguish numerous molecular mediators and cellular factors, such as interleukins [64]. Other cytokines could be explored for therapeutic usage. For instance, interferon beta-1a has led to clinical improvement in hospitalized COVID-19 patients [65], which highlights interferon beta-1a as a potential therapy for COVID-19 [66,67]. Therefore, one of the approaches could be to modify the cytokines in order to reduce the inflammatory-induced damage, optimize antiviral immune functions and maintain the homeostasis (metabolic, regeneration, hormonal, etc.) of the vital tissues throughout COVID-19’s evolution.
Diverse diseases, pathological conditions and health problems worsen COVID-19 prognosis. These include two of the major health problems of our modern societies: obesity and ageing. Indeed, obese and ageing subjects have a chronic inflammation status [68,69] that is considered as a “basal status” upon which COVID-19 builds further inflammatory phenomena, thus explaining why obese patients are more susceptible to COVID-19, especially given the impacts of physical inactivity and sedentary behavior in the case of autoimmune diseases [70]. All these elements indicate an over-“stimulation” of the immune system even before COVID-19 is established. These elements are the key characteristics of COVID-19-crisis-related health consequences.
On the other hand, the post-COVID-19 era represents an additional health challenge for the general population and not only for those infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The post-COVID-19 era will bring challenges that will add to the pre-existing healthcare system problems, including post-intensive care syndrome, reduced healthcare for non-COVID-19 patients and other diseases that may worsen during COVID-19.
Those infected with SARS-CoV-2 may be affected by COVID-19 consequences on their health, such as fatigue and shortness of breath [71], which will limit their ability to perform the required level of physical activity. Therefore, these patients need, for instance, an “exercise substitute”. In addition, the general population will still be affected by the consequences of confinement and the economic crisis in terms of their health, such as those resulting from a sedentary lifestyle and confinement, including obesity [72], cardiovascular diseases [73], diabetes [74] and possible immunity decline [47].
Therefore, there is a need for effective approaches to tackle this multi-level crisis, especially with the limited number of approved therapeutic options and the possibly limited impacts of the developed vaccines. It remains crucial to find new therapeutic tools and possible interventions. In light of this, the exercise-induced protein known as secreted protein acidic and rich in cysteine (SPARC) emerges as a potential therapeutic option. SPARC/Sparc was initially identified as an exercise-induced gene, both in vivo and in vitro, following functional genomics explorations [75,76]. Studies have suggested that SPARC is responsible for exercise-induced muscle phenotype changes [77] and that it might mediate exercise-induced effects [78,79]. Thus, SPARC could be an “exercise substitute” [79].
Importantly, the properties mediated and the effects induced by SPARC suggest that the induction of SPARC administration/expression could counteract risk factors for severe forms of COVID-19, limit the impacts of the pandemic measures during the post-COVID-19 era and even form part of the therapies used for hospitalized COVID-19 patients. Among SPARC’s properties that could lead to possible therapeutic applications, we have anti-inflammatory [80], anti-ageing [78,79], anti-sarcopenia/muscle atrophy [81] and anti-obesity properties [82], as well as SPARC’s importance for immunity [83]. The potential anticancer property of SPARC is also worth mentioning in this context [82,84], since cancer might increase the risk of COVID-19 adverse outcomes [46,85,86,87]. Thus, SPARC reverses numerous negative impacts of obesity, in addition to other factors, such ageing and diverse obesity-related and age-related health conditions, that render individuals more susceptible to COVID-19.
SPARC, due to its various properties, might constitute an efficient therapeutic tool, since it acts on various levels (Figure 1) that would allow it to tackle health problems related to COVID-19 severe-form risk factors, as well as public health problems during the post-COVID-19 era, and to help COVID-19 patients both during hospitalization and in the management of long COVID-19 (complications following acute illness).
Exercise remains a strong option in the context of the COVID-19 crisis as well as the post-COVID-19 era. However, with many individuals being unable (disability, hospitalization, etc.) or unwilling (mental health) to perform the required physical activity, SPARC could emerge as an alternative [79] or as an additional therapeutic tool worth exploring to tackle COVID-19 and its consequences on various levels.
According to the different pathways at the molecular and cellular levels linking SPARC to exercise, the resulting phenotypic changes will involve increasing myogenesis, the extracellular matrix and muscle glucose transporter expression, as well as decreasing adipogenesis and mitochondrial dysfunction [88]. The exploration of such pathways represents a starting point towards the development of novel therapeutic options for COVID-19 and its complications, which are urgently required, especially with the risk of the emergence of COVID-19 variants [89,90,91,92].

Author Contributions

A.G. designed and wrote the manuscript. A.G., M.Y. and J.S.-A. discussed the content and exchanged ideas and suggestions throughout the writing process and edited and critically revised the paper. All authors have read and agreed to the published version of the manuscript.

Funding

This work received no external funding.

Acknowledgments

Abdelaziz Ghanemi received a scholarship under the Merit Scholarship Program for foreign students from the Ministry of Education and Higher Education of Quebec, Canada. The Fonds de Recherche du Québec—Nature et technologies (FRQNT) is responsible for managing the program (Bourses d’excellence pour étudiants étrangers du Ministère de l’Éducation et de l’Enseignement supérieur du Québec, Le Fonds de Recherche du Québec—Nature et technologies (FRQNT) est responsable de la gestion du programme). Abdelaziz Ghanemi received the scholarship «Bourse Tremplin—Stage en milieu de pratique» (internship scholarship) from the Fonds de Recherche du Québec—Sante (FRQS), Quebec, Canada. Abdelaziz Ghanemi received the scholarship “Inspirational journey” («Un parcours inspirant») from la Caisse Desjardins de l’Université Laval, Quebec, Canada. Figure 1 was created using images from https://mindthegraph.com/ (accessed on 6 November 2022).

Conflicts of Interest

The authors declare that there are no conflict of interest.

References

  1. Lüthy, I.A.; Ritacco, V.; Kantor, I.N. One hundred years after the “Spanish” flu. Medicina 2018, 78, 113–118. [Google Scholar] [PubMed]
  2. Nicola, M.; Alsafi, Z.; Sohrabi, C.; Kerwan, A.; Al-Jabir, A.; Iosifidis, C.; Agha, M.; Agha, R. The socio-economic implications of the coronavirus pandemic (COVID-19): A review. Int. J. Surg. 2020, 78, 185–193. [Google Scholar] [CrossRef] [PubMed]
  3. Rasheed, R.; Rizwan, A.; Javed, H.; Sharif, F.; Zaidi, A. Socio-economic and environmental impacts of COVID-19 pandemic in Pakistan-an integrated analysis. Environ. Sci. Pollut. Res. Int. 2021, 28, 19926–19943. [Google Scholar] [CrossRef] [PubMed]
  4. Alvarez-Peregrina, C.; Martinez-Perez, C.; Villa-Collar, C.; Andreu-Vázquez, C.; Ruiz-Pomeda, A.; Sánchez-Tena, M. Impact of COVID-19 Home Confinement in Children’s Refractive Errors. Int. J. Environ. Res. Public Health 2021, 18, 5347. [Google Scholar] [CrossRef] [PubMed]
  5. Castañeda-Babarro, A.; Arbillaga-Etxarri, A.; Gutiérrez-Santamaría, B.; Coca, A. Physical Activity Change during COVID-19 Confinement. Int. J. Environ. Res. Public Health 2020, 17, 6878. [Google Scholar] [CrossRef]
  6. Garcia-Adasme, S.I.; Cárdenas-Rebollo, J.M.; Jimenez-Perianes, A.; Lalinde, M.; Jimeno, S.; Ventura, P.S.; Díaz, A.; López-Escobar, A. Pediatric home confinement due to COVID-19: Somatic and anxiety spectrum consequences. J. Clin. Nurs. 2021, 30, 3238–3248. [Google Scholar] [CrossRef]
  7. Galanti, T.; Guidetti, G.; Mazzei, E.; Zappalà, S.; Toscano, F. Work from Home during the COVID-19 Outbreak: The Impact on Employees’ Remote Work Productivity, Engagement, and Stress. J. Occup. Environ. Med. 2021, 63, e426–e432. [Google Scholar] [CrossRef]
  8. Birimoglu Okuyan, C.; Begen, M.A. Working from home during the COVID-19 pandemic, its effects on health, and recommendations: The pandemic and beyond. Perspect. Psychiatr. Care 2022, 58, 173–179. [Google Scholar] [CrossRef]
  9. Barone Gibbs, B.; Kline, C.E.; Huber, K.A.; Paley, J.L.; Perera, S. COVID-19 shelter-at-home and work, lifestyle and well-being in desk workers. Occup. Med. 2021, 71, 86–94. [Google Scholar] [CrossRef]
  10. Radulović, A.H.; Žaja, R.; Milošević, M.; Radulović, B.; Luketić, I.; Božić, T. Work from home and musculoskeletal pain in telecommunications workers during COVID-19 pandemic: A pilot study. Arh. Hig. Rada Toksikol. 2021, 72, 232–239. [Google Scholar] [CrossRef]
  11. de Leeuw, A.J.M.; Oude Luttikhuis, M.A.M.; Wellen, A.C.; Müller, C.; Calkhoven, C.F. Obesity and its impact on COVID-19. J. Mol. Med. 2021, 99, 899–915. [Google Scholar] [CrossRef]
  12. Yu, W.; Rohli, K.E.; Yang, S.; Jia, P. Impact of obesity on COVID-19 patients. J. Diabetes Complicat. 2021, 35, 107817. [Google Scholar] [CrossRef]
  13. Sallis, R.; Young, D.R.; Tartof, S.Y.; Sallis, J.F.; Sall, J.; Li, Q.; Smith, G.N.; Cohen, D.A. Physical inactivity is associated with a higher risk for severe COVID-19 outcomes: A study in 48,440 adult patients. Br. J. Sports Med. 2021, 55, 1099–1105. [Google Scholar] [CrossRef] [PubMed]
  14. Després, J.P. Severe COVID-19 outcomes—The role of physical activity. Nat. Rev. Endocrinol. 2021, 17, 451–452. [Google Scholar] [CrossRef] [PubMed]
  15. Balanzá-Martínez, V.; Atienza-Carbonell, B.; Kapczinski, F.; De Boni, R.B. Lifestyle behaviours during the COVID-19—Time to connect. Acta Psychiatr. Scand. 2020, 141, 399–400. [Google Scholar] [CrossRef] [PubMed]
  16. Ammar, A.; Brach, M.; Trabelsi, K.; Chtourou, H.; Boukhris, O.; Masmoudi, L.; Bouaziz, B.; Bentlage, E.; How, D.; Ahmed, M.; et al. Effects of COVID-19 Home Confinement on Eating Behaviour and Physical Activity: Results of the ECLB-COVID19 International Online Survey. Nutrients 2020, 12, 1583. [Google Scholar] [CrossRef]
  17. Panahi, S.; Tremblay, A. Sedentariness and Health: Is Sedentary Behavior More than Just Physical Inactivity? Front. Public Health 2018, 6, 258. [Google Scholar] [CrossRef] [PubMed]
  18. Chaput, J.P.; Tremblay, A. Acute effects of knowledge-based work on feeding behavior and energy intake. Physiol. Behav. 2007, 90, 66–72. [Google Scholar] [CrossRef]
  19. Chaput, J.P.; Drapeau, V.; Poirier, P.; Teasdale, N.; Tremblay, A. Glycemic instability and spontaneous energy intake: Association with knowledge-based work. Psychosom. Med. 2008, 70, 797–804. [Google Scholar] [CrossRef]
  20. Pfefferbaum, B.; North, C.S. Mental Health and the COVID-19 Pandemic. N. Engl. J. Med. 2020, 383, 510–512. [Google Scholar] [CrossRef]
  21. Samji, H.; Wu, J.; Ladak, A.; Vossen, C.; Stewart, E.; Dove, N.; Long, D.; Snell, G. Review: Mental health impacts of the COVID-19 pandemic on children and youth—A systematic review. Child Adolesc. Ment. Health 2022, 27, 173–189. [Google Scholar] [CrossRef] [PubMed]
  22. The Lancet, P. COVID-19 and mental health. Lancet Psychiatry 2021, 8, 87. [Google Scholar] [CrossRef] [PubMed]
  23. Hossain, M.M.; Tasnim, S.; Sultana, A.; Faizah, F.; Mazumder, H.; Zou, L.; McKyer, E.L.J.; Ahmed, H.U.; Ma, P. Epidemiology of mental health problems in COVID-19: A review. F1000Research 2020, 9, 636. [Google Scholar] [CrossRef]
  24. Pandey, K.; Thurman, M.; Johnson, S.D.; Acharya, A.; Johnston, M.; Klug, E.A.; Olwenyi, O.A.; Rajaiah, R.; Byrareddy, S.N. Mental Health Issues During and After COVID-19 Vaccine Era. Brain Res. Bull. 2021, 176, 161–173. [Google Scholar] [CrossRef] [PubMed]
  25. Talen, M.R.; Mann, M.M. Obesity and Mental Health. Prim. Care Clin. Off. Pract. 2009, 36, 287–305. [Google Scholar] [CrossRef] [PubMed]
  26. Van Strien, T. Causes of Emotional Eating and Matched Treatment of Obesity. Curr. Diabetes Rep. 2018, 18, 35. [Google Scholar] [CrossRef]
  27. Ekim, A.; Ocakci, A.F. Emotional eating: Really hungry or just angry? J. Child Health Care 2021, 25, 562–572. [Google Scholar] [CrossRef]
  28. Lazarevich, I.; Irigoyen Camacho, M.E.; Velázquez-Alva, M.D.C.; Zepeda Zepeda, M. Relationship among obesity, depression, and emotional eating in young adults. Appetite 2016, 107, 639–644. [Google Scholar] [CrossRef]
  29. Konttinen, H.; van Strien, T.; Männistö, S.; Jousilahti, P.; Haukkala, A. Depression, emotional eating and long-term weight changes: A population-based prospective study. Int. J. Behav. Nutr. Phys. Act. 2019, 16, 28. [Google Scholar] [CrossRef]
  30. van Strien, T.; Cebolla, A.; Etchemendy, E.; Gutiérrez-Maldonado, J.; Ferrer-García, M.; Botella, C.; Baños, R. Emotional eating and food intake after sadness and joy. Appetite 2013, 66, 20–25. [Google Scholar] [CrossRef]
  31. Marx, W.; Lane, M.; Hockey, M.; Aslam, H.; Berk, M.; Walder, K.; Borsini, A.; Firth, J.; Pariante, C.M.; Berding, K.; et al. Diet and depression: Exploring the biological mechanisms of action. Mol. Psychiatry 2021, 26, 134–150. [Google Scholar] [CrossRef] [PubMed]
  32. Esfahani, S.B.; Pal, S. Obesity, mental health, and sexual dysfunction: A critical review. Health Psychol. Open 2018, 5, 2055102918786867. [Google Scholar] [CrossRef] [PubMed]
  33. Devlin, M.J.; Yanovski, S.Z.; Wilson, G.T. Obesity: What Mental Health Professionals Need to Know. Am. J. Psychiatry 2000, 157, 854–866. [Google Scholar] [CrossRef] [PubMed]
  34. Katta, N.; Loethen, T.; Lavie, C.J.; Alpert, M.A. Obesity and Coronary Heart Disease: Epidemiology, Pathology, and Coronary Artery Imaging. Curr. Probl. Cardiol. 2021, 46, 100655. [Google Scholar] [CrossRef]
  35. Jensen, J.C.; Dardari, Z.A.; Blaha, M.J.; White, S.; Shaw, L.J.; Rumberger, J.; Rozanski, A.; Berman, D.S.; Budoff, M.J.; Nasir, K.; et al. Association of Body Mass Index with Coronary Artery Calcium and Subsequent Cardiovascular Mortality: The Coronary Artery Calcium Consortium. Circ. Cardiovasc. Imaging 2020, 13, e009495. [Google Scholar] [CrossRef] [PubMed]
  36. Kachur, S.; Lavie, C.J.; de Schutter, A.; Milani, R.V.; Ventura, H.O. Obesity and cardiovascular diseases. Minerva Med. 2017, 108, 212–228. [Google Scholar] [CrossRef]
  37. Maggio, C.A.; Pi-Sunyer, F.X. Obesity and type 2 diabetes. Endocrinol. Metab. Clin. N. Am. 2003, 32, 805–822. [Google Scholar] [CrossRef]
  38. Kahn, S.E.; Hull, R.L.; Utzschneider, K.M. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 2006, 444, 840–846. [Google Scholar] [CrossRef]
  39. Polyzos, S.A.; Kountouras, J.; Mantzoros, C.S. Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics. Metabolism 2019, 92, 82–97. [Google Scholar] [CrossRef]
  40. Milić, S.; Lulić, D.; Štimac, D. Non-alcoholic fatty liver disease and obesity: Biochemical, metabolic and clinical presentations. World J. Gastroenterol. 2014, 20, 9330–9337. [Google Scholar] [CrossRef]
  41. Iyengar, N.M.; Gucalp, A.; Dannenberg, A.J.; Hudis, C.A. Obesity and Cancer Mechanisms: Tumor Microenvironment and Inflammation. J. Clin. Oncol. 2016, 34, 4270–4276. [Google Scholar] [CrossRef] [PubMed]
  42. Kolb, R.; Sutterwala, F.S.; Zhang, W. Obesity and cancer: Inflammation bridges the two. Curr. Opin. Pharmacol. 2016, 29, 77–89. [Google Scholar] [CrossRef] [PubMed]
  43. Avgerinos, K.I.; Spyrou, N.; Mantzoros, C.S.; Dalamaga, M. Obesity and cancer risk: Emerging biological mechanisms and perspectives. Metabolism 2019, 92, 121–135. [Google Scholar] [CrossRef] [PubMed]
  44. Lima-Martínez, M.M.; Carrera Boada, C.; Madera-Silva, M.D.; Marín, W.; Contreras, M. COVID-19 and diabetes: A bidirectional relationship. Clin. Investig. Arterioscler. 2021, 33, 151–157. [Google Scholar] [CrossRef]
  45. Jothimani, D.; Venugopal, R.; Abedin, M.F.; Kaliamoorthy, I.; Rela, M. COVID-19 and the liver. J. Hepatol. 2020, 73, 1231–1240. [Google Scholar] [CrossRef]
  46. Lee, K.A.; Ma, W.; Sikavi, D.R.; Drew, D.A.; Nguyen, L.H.; Bowyer, R.C.E.; Cardoso, M.J.; Fall, T.; Freidin, M.B.; Gomez, M.; et al. Cancer and Risk of COVID-19 through a General Community Survey. Oncologist 2021, 26, e182–e185. [Google Scholar] [CrossRef]
  47. Damiot, A.; Pinto, A.J.; Turner, J.E.; Gualano, B. Immunological Implications of Physical Inactivity among Older Adults during the COVID-19 Pandemic. Gerontology 2020, 66, 431–438. [Google Scholar] [CrossRef]
  48. Burini, R.C.; Anderson, E.; Durstine, J.L.; Carson, J.A. Inflammation, physical activity, and chronic disease: An evolutionary perspective. Sports Med. Health Sci. 2020, 2, 1–6. [Google Scholar] [CrossRef]
  49. Johnson, N.A.; Sultana, R.N.; Brown, W.J.; Bauman, A.E.; Gill, T. Physical activity in the management of obesity in adults: A position statement from Exercise and Sport Science Australia. J. Sci. Med. Sport 2021, 24, 1245–1254. [Google Scholar] [CrossRef]
  50. Jakicic, J.M.; Rogers, R.J.; Collins, A.M.; Jackson, R. Strategies for Physical Activity Interventions in the Treatment of Obesity. Endocrinol. Metab. Clin. N. Am. 2020, 49, 289–301. [Google Scholar] [CrossRef]
  51. Wiechert, M.; Holzapfel, C. Nutrition Concepts for the Treatment of Obesity in Adults. Nutrients 2021, 14, 169. [Google Scholar] [CrossRef] [PubMed]
  52. Swift, D.L.; McGee, J.E.; Earnest, C.P.; Carlisle, E.; Nygard, M.; Johannsen, N.M. The Effects of Exercise and Physical Activity on Weight Loss and Maintenance. Prog. Cardiovasc. Dis. 2018, 61, 206–213. [Google Scholar] [CrossRef] [PubMed]
  53. Oppert, J.M.; Bellicha, A.; Ciangura, C. Physical activity in management of persons with obesity. Eur. J. Intern. Med. 2021, 93, 8–12. [Google Scholar] [CrossRef] [PubMed]
  54. Elagizi, A.; Kachur, S.; Carbone, S.; Lavie, C.J.; Blair, S.N. A Review of Obesity, Physical Activity, and Cardiovascular Disease. Curr. Obes. Rep. 2020, 9, 571–581. [Google Scholar] [CrossRef]
  55. Jakicic, J.M.; Davis, K.K. Obesity and physical activity. Psychiatr. Clin. N. Am. 2011, 34, 829–840. [Google Scholar] [CrossRef]
  56. Chao, A.M.; Quigley, K.M.; Wadden, T.A. Dietary interventions for obesity: Clinical and mechanistic findings. J. Clin. Investig. 2021, 131, e140065. [Google Scholar] [CrossRef]
  57. Aaseth, J.; Ellefsen, S.; Alehagen, U.; Sundfør, T.M.; Alexander, J. Diets and drugs for weight loss and health in obesity—An update. Biomed. Pharmacother. 2021, 140, 111789. [Google Scholar] [CrossRef]
  58. Moreno, B.; Bellido, D.; Sajoux, I.; Goday, A.; Saavedra, D.; Crujeiras, A.B.; Casanueva, F.F. Comparison of a very low-calorie-ketogenic diet with a standard low-calorie diet in the treatment of obesity. Endocrine 2014, 47, 793–805. [Google Scholar] [CrossRef]
  59. Soy, M.; Keser, G.; Atagündüz, P.; Tabak, F.; Atagündüz, I.; Kayhan, S. Cytokine storm in COVID-19: Pathogenesis and overview of anti-inflammatory agents used in treatment. Clin. Rheumatol. 2020, 39, 2085–2094. [Google Scholar] [CrossRef]
  60. Alunno, A.; Carubbi, F.; Rodríguez-Carrio, J. Storm, typhoon, cyclone or hurricane in patients with COVID-19? Beware of the same storm that has a different origin. RMD Open 2020, 6, e001295. [Google Scholar] [CrossRef]
  61. Karki, R.; Kanneganti, T.D. Innate immunity, cytokine storm, and inflammatory cell death in COVID-19. J. Transl. Med. 2022, 20, 542. [Google Scholar] [CrossRef] [PubMed]
  62. Zanza, C.; Romenskaya, T.; Manetti, A.C.; Franceschi, F.; La Russa, R.; Bertozzi, G.; Maiese, A.; Savioli, G.; Volonnino, G.; Longhitano, Y. Cytokine Storm in COVID-19: Immunopathogenesis and Therapy. Medicina 2022, 58, 144. [Google Scholar] [CrossRef] [PubMed]
  63. Tang, S.W.; Helmeste, D.M.; Leonard, B.E. COVID-19 as a polymorphic inflammatory spectrum of diseases: A review with focus on the brain. Acta Neuropsychiatr. 2023, 1–22. [Google Scholar] [CrossRef] [PubMed]
  64. Montazersaheb, S.; Hosseiniyan Khatibi, S.M.; Hejazi, M.S.; Tarhriz, V.; Farjami, A.; Ghasemian Sorbeni, F.; Farahzadi, R.; Ghasemnejad, T. COVID-19 infection: An overview on cytokine storm and related interventions. Virol. J. 2022, 19, 92. [Google Scholar] [CrossRef]
  65. Monk, P.D.; Marsden, R.J.; Tear, V.J.; Brookes, J.; Batten, T.N.; Mankowski, M.; Gabbay, F.J.; Davies, D.E.; Holgate, S.T.; Ho, L.P.; et al. Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: A randomised, double-blind, placebo-controlled, phase 2 trial. Lancet Respir. Med. 2021, 9, 196–206. [Google Scholar] [CrossRef]
  66. Peiffer-Smadja, N.; Yazdanpanah, Y. Nebulised interferon beta-1a for patients with COVID-19. Lancet Respir. Med. 2021, 9, 122–123. [Google Scholar] [CrossRef]
  67. Bosi, E.; Bosi, C.; Rovere Querini, P.; Mancini, N.; Calori, G.; Ruggeri, A.; Canzonieri, C.; Callegaro, L.; Clementi, M.; De Cobelli, F.; et al. Interferon β-1a (IFNβ-1a) in COVID-19 patients (INTERCOP): Study protocol for a randomized controlled trial. Trials 2020, 21, 939. [Google Scholar] [CrossRef]
  68. Monteiro, R.; Azevedo, I. Chronic inflammation in obesity and the metabolic syndrome. Mediat. Inflamm. 2010, 2010, 289645. [Google Scholar] [CrossRef]
  69. Sendama, W. The effect of ageing on the resolution of inflammation. Ageing Res. Rev. 2020, 57, 101000. [Google Scholar] [CrossRef]
  70. Pinto, A.J.; Roschel, H.; de Sá Pinto, A.L.; Lima, F.R.; Pereira, R.M.R.; Silva, C.A.; Bonfá, E.; Gualano, B. Physical inactivity and sedentary behavior: Overlooked risk factors in autoimmune rheumatic diseases? Autoimmun. Rev. 2017, 16, 667–674. [Google Scholar] [CrossRef]
  71. Aiyegbusi, O.L.; Hughes, S.E.; Turner, G.; Rivera, S.C.; McMullan, C.; Chandan, J.S.; Haroon, S.; Price, G.; Davies, E.H.; Nirantharakumar, K.; et al. Symptoms, complications and management of long COVID: A review. J. R. Soc. Med. 2021, 114, 428–442. [Google Scholar] [CrossRef] [PubMed]
  72. Biddle, S.J.H.; García Bengoechea, E.; Pedisic, Z.; Bennie, J.; Vergeer, I.; Wiesner, G. Screen Time, Other Sedentary Behaviours, and Obesity Risk in Adults: A Review of Reviews. Curr. Obes. Rep. 2017, 6, 134–147. [Google Scholar] [CrossRef] [PubMed]
  73. Zhuang, Z.; Gao, M.; Yang, R.; Li, N.; Liu, Z.; Cao, W.; Huang, T. Association of physical activity, sedentary behaviours and sleep duration with cardiovascular diseases and lipid profiles: A Mendelian randomization analysis. Lipids Health Dis. 2020, 19, 86. [Google Scholar] [CrossRef]
  74. Defeudis, G.; Mazzilli, R.; Tenuta, M.; Rossini, G.; Zamponi, V.; Olana, S.; Faggiano, A.; Pozzilli, P.; Isidori, A.M.; Gianfrilli, D. Erectile dysfunction and diabetes: A melting pot of circumstances and treatments. Diabetes Metab. Res. Rev. 2022, 38, e3494. [Google Scholar] [CrossRef] [PubMed]
  75. Riedl, I.; Yoshioka, M.; Nishida, Y.; Tobina, T.; Paradis, R.; Shono, N.; Tanaka, H.; St-Amand, J. Regulation of skeletal muscle transcriptome in elderly men after 6 weeks of endurance training at lactate threshold intensity. Exp. Gerontol. 2010, 45, 896–903. [Google Scholar] [CrossRef]
  76. Melouane, A.; Yoshioka, M.; Kanzaki, M.; St-Amand, J. Sparc, an EPS-induced gene, modulates the extracellular matrix and mitochondrial function via ILK/AMPK pathways in C2C12 cells. Life Sci. 2019, 229, 277–287. [Google Scholar] [CrossRef]
  77. Ghanemi, A.; Melouane, A.; Yoshioka, M.; St-Amand, J. Exercise Training of Secreted Protein Acidic and Rich in Cysteine (Sparc) KO Mice Suggests That Exercise-Induced Muscle Phenotype Changes Are SPARC-Dependent. Appl. Sci. 2020, 10, 9108. [Google Scholar] [CrossRef]
  78. Ghanemi, A.; Melouane, A.; Yoshioka, M.; St-Amand, J. Secreted Protein Acidic and Rich in Cysteine (Sparc) KO Leads to an Accelerated Ageing Phenotype Which Is Improved by Exercise Whereas SPARC Overexpression Mimics Exercise Effects in Mice. Metabolites 2022, 12, 125. [Google Scholar] [CrossRef]
  79. Ghanemi, A.; Yoshioka, M.; St-Amand, J. Genetic Expression between Ageing and Exercise: Secreted Protein Acidic and Rich in Cysteine as a Potential “Exercise Substitute” Antiageing Therapy. Genes 2022, 13, 950. [Google Scholar] [CrossRef]
  80. Ghanemi, A.; Yoshioka, M.; St-Amand, J. Secreted protein acidic and rich in cysteine and inflammation: Another homeostatic property? Cytokine 2020, 133, 155179. [Google Scholar] [CrossRef]
  81. Ghanemi, A.; Yoshioka, M.; St-Amand, J. Secreted Protein Acidic and Rich in Cysteine as an Exercise-Induced Gene: Towards Novel Molecular Therapies for Immobilization-Related Muscle Atrophy in Elderly Patients. Genes 2022, 13, 1014. [Google Scholar] [CrossRef] [PubMed]
  82. Nagaraju, G.P.; Sharma, D. Anti-cancer role of SPARC, an inhibitor of adipogenesis. Cancer Treat. Rev. 2011, 37, 559–566. [Google Scholar] [CrossRef] [PubMed]
  83. Rempel, S.A.; Hawley, R.C.; Gutiérrez, J.A.; Mouzon, E.; Bobbitt, K.R.; Lemke, N.; Schultz, C.R.; Schultz, L.R.; Golembieski, W.; Koblinski, J.; et al. Splenic and immune alterations of the Sparc-null mouse accompany a lack of immune response. Genes Immun. 2007, 8, 262–274. [Google Scholar] [CrossRef]
  84. Ghanemi, A.; Yoshioka, M.; St-Amand, J. Secreted protein acidic and rich in cysteine and cancer: A homeostatic hormone? Cytokine 2020, 127, 154996. [Google Scholar] [CrossRef] [PubMed]
  85. Liu, C.; Zhao, Y.; Okwan-Duodu, D.; Basho, R.; Cui, X. COVID-19 in cancer patients: Risk, clinical features, and management. Cancer Biol. Med. 2020, 17, 519–527. [Google Scholar] [CrossRef]
  86. Tian, J.; Miao, X. Challenges and recommendations for cancer care in the COVID-19 pandemic. Cancer Biol. Med. 2020, 17, 515–518. [Google Scholar] [CrossRef]
  87. Gosain, R.; Abdou, Y.; Singh, A.; Rana, N.; Puzanov, I.; Ernstoff, M.S. COVID-19 and Cancer: A Comprehensive Review. Curr. Oncol. Rep. 2020, 22, 53. [Google Scholar] [CrossRef]
  88. Ghanemi, A.; Yoshioka, M.; St-Amand, J. Secreted Protein Acidic and Rich in Cysteine (SPARC)-Mediated Exercise Effects: Illustrative Molecular Pathways against Various Diseases. Diseases 2023, 11, 33. [Google Scholar] [CrossRef]
  89. Fernandes, Q.; Inchakalody, V.P.; Merhi, M.; Mestiri, S.; Taib, N.; Moustafa Abo El-Ella, D.; Bedhiafi, T.; Raza, A.; Al-Zaidan, L.; Mohsen, M.O.; et al. Emerging COVID-19 variants and their impact on SARS-CoV-2 diagnosis, therapeutics and vaccines. Ann. Med. 2022, 54, 524–540. [Google Scholar] [CrossRef]
  90. Zabidi, N.Z.; Liew, H.L.; Farouk, I.A.; Puniyamurti, A.; Yip, A.J.W.; Wijesinghe, V.N.; Low, Z.Y.; Tang, J.W.; Chow, V.T.K.; Lal, S.K. Evolution of SARS-CoV-2 Variants: Implications on Immune Escape, Vaccination, Therapeutic and Diagnostic Strategies. Viruses 2023, 15, 944. [Google Scholar] [CrossRef]
  91. Aleem, A.; Akbar Samad, A.B.; Vaqar, S. Emerging Variants of SARS-CoV-2 And Novel Therapeutics Against Coronavirus (COVID-19). In StatPearls; StatPearls Publishing LLC: Treasure Island, FL, USA, 2023. [Google Scholar]
  92. Hadj Hassine, I. COVID-19 vaccines and variants of concern: A review. Rev. Med. Virol. 2022, 32, e2313. [Google Scholar] [CrossRef] [PubMed]
Figure 1. Properties of secreted protein acidic and rich in cysteine (SPARC) as a potential therapeutic option to manage coronavirus-disease-2019 (COVID-19)-related health consequences on various levels.
Figure 1. Properties of secreted protein acidic and rich in cysteine (SPARC) as a potential therapeutic option to manage coronavirus-disease-2019 (COVID-19)-related health consequences on various levels.
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Ghanemi, A.; Yoshioka, M.; St-Amand, J. Secreted Protein Acidic and Rich in Cysteine (SPARC) to Manage Coronavirus Disease-2019 (COVID-19) Pandemic and the Post-COVID-19 Health Crisis. Medicines 2023, 10, 32. https://doi.org/10.3390/medicines10050032

AMA Style

Ghanemi A, Yoshioka M, St-Amand J. Secreted Protein Acidic and Rich in Cysteine (SPARC) to Manage Coronavirus Disease-2019 (COVID-19) Pandemic and the Post-COVID-19 Health Crisis. Medicines. 2023; 10(5):32. https://doi.org/10.3390/medicines10050032

Chicago/Turabian Style

Ghanemi, Abdelaziz, Mayumi Yoshioka, and Jonny St-Amand. 2023. "Secreted Protein Acidic and Rich in Cysteine (SPARC) to Manage Coronavirus Disease-2019 (COVID-19) Pandemic and the Post-COVID-19 Health Crisis" Medicines 10, no. 5: 32. https://doi.org/10.3390/medicines10050032

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