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Dental Materials Design and Innovative Treatment Approach

Francesco Gianfreda
1 and
Patrizio Bollero
Department of Industrial Engineering, University of Rome “Tor Vergata”, 00133 Rome, Italy
Department of System Medicine, University of Rome “Tor Vergata”, 00133 Rome, Italy
Author to whom correspondence should be addressed.
Dent. J. 2023, 11(3), 85;
Submission received: 15 February 2023 / Revised: 27 February 2023 / Accepted: 7 March 2023 / Published: 17 March 2023
(This article belongs to the Special Issue Dental Materials Design and Innovative Treatment Approach)
In recent years, technological innovation has had exponential growth, resulting in positive implications in dentistry.
In the field of implantology, the development of bioactive surfaces and biomaterials has made it possible to enhance the early biological response [1,2,3,4].
In addition, Gianfreda et al. showed that from a microscopical point of view different bioactive surfaces react differently to decontamination processes. This also leads to a different healing ability around implants with peri-implantitis treated with different decontamination systems [5].
Similarly, the use of biomaterials as scaffolds for bone regeneration has undergone an incredible development in recent years. One of the most innovative aspects is certainly the use of demineralized dentin as autologous graft material [6,7,8]. According to some authors, BMPs may be present in these grafts and could have an osteoconductive effect [9].
In the field of prosthetics, the development of CAD-CAM technologies and the advent of intraoral and facial scanners have allowed a faster and increasingly tailor-made approach, thanks to the use of milled titanium bars and milled ceramic materials [10,11,12,13,14].
In the field of orthodontics, the advent of transparent aligners has drastically changed the approach to the patient in the developmental age. In fact, aligners allow you to obtain predictable and fast results without compromising the patient’s aesthetics [15].
This Special Issue is concerned with all aspects of all dental specialties dealing with this topic. There is an important question that we can ask ourselves: what are the most interesting materials in all of the sub-fields of dentistry? How can the latest generation’s materials and technologies influence the patient care plans?

Author Contributions

Conceptualization, F.G. and P.B.; investigation, F.G.; resources, P.B.; data curation, F.G.; writing—original draft preparation, F.G.; writing—review and editing, P.B.; visualization, F.G.; supervision, P.B.; project administration, P.B.; funding acquisition, P.B. All authors have read and agreed to the published version of the manuscript.

Institutional Review Board Statement

Not applicable.

Informed Consent Statement

Not applicable.

Data Availability Statement

Not applicable.


Thanks to all the authors and peer reviewers for their valuable contributions to this Special Issue. We would also like to express our acknowledgments to all the staff and people involved in this Special Issue.

Conflicts of Interest

The authors declare no conflict of interest.


  1. Gianfreda, F.; Antonacci, D.; Raffone, C.; Muzzi, M.; Pistilli, V.; Bollero, P. Microscopic Characterization of Bioactivate Implant Surfaces: Increasing Wettability Using Salts and Dry Technology. Materials 2021, 14, 2608. [Google Scholar] [CrossRef] [PubMed]
  2. Gianfreda, F.; Raffone, C.; Antonacci, D.; Mussano, F.; Genova, T.; Chinigò, G.; Canullo, L.; Bollero, P. Early Biological Response of an Ultra-Hydrophilic Implant Surface Activated by Salts and Dry Technology: An In-Vitro Study. Appl. Sci. 2021, 11, 6120. [Google Scholar] [CrossRef]
  3. Mastrangelo, F.; Quaresima, R.; Canullo, L.; Scarano, A.; Muzio, L.L.; Piattelli, A. Effects of Novel Laser Dental Implant Microtopography on Human Osteoblast Proliferation and Bone Deposition. Int. J. Oral Maxillofac. Implant. 2020, 35, 320–329. [Google Scholar] [CrossRef] [PubMed]
  4. Mastrangelo, F.; Parma-Benfenati, S.; Quaresima, R. Biologic Bone Behavior During the Osseointegration Process: Histologic, Histomorphometric, and SEM-EDX Evaluations. Int. J. Periodontics Restor. Dent. 2023, 43, 65–72. [Google Scholar] [CrossRef] [PubMed]
  5. Gianfreda, F.; Bollero, P.; Muzzi, M.; Di Giulio, A.; Nicolai, E.; Canullo, L. The Effects of Ultrasonic Scaling and Air-Abrasive Powders on the Decontamination of 9 Implant-Abutment Surfaces: Scanning Electron Analysis and In Vitro Study. Dent. J. 2022, 10, 36. [Google Scholar] [CrossRef] [PubMed]
  6. Mancini, L.; Romandini, M.; Fratini, A.; Americo, L.M.; Panda, S.; Marchetti, E. Biomaterials for Periodontal and Peri-Implant Regeneration. Materials 2021, 14, 3319. [Google Scholar] [CrossRef] [PubMed]
  7. Mummolo, S.; Mancini, L.; Quinzi, V.; D’Aquino, R.; Marzo, G.; Marchetti, E. Rigenera® Autologous Micrografts in Oral Regeneration: Clinical, Histological, and Radiographical Evaluations. Appl. Sci. 2020, 10, 5084. [Google Scholar] [CrossRef]
  8. Moses, O.; Bengazi, F.; Ferri, M.; Gianfreda, F.; Velez, J.U.; Botticelli, D.; Canullo, L. Bioactivated Implant Surfaces Placed in Healed Sites or Extraction Sockets: A Preliminary Experimental Study in Dogs. Int. J. Oral Maxillofac. Implants 2022, 37, 963–970. [Google Scholar] [CrossRef] [PubMed]
  9. Minetti, E.; Celko, M.; Contessi, M.; Carini, F.; Gambardella, U.; Giacometti, E.; Santillana, J.; Beca Campoy, T.; Schmitz, J.H.; Libertucci, M.; et al. Implants Survival Rate in Regenerated Sites with Innovative Graft Biomaterials: 1 Year Follow-Up. Materials 2021, 14, 5292. [Google Scholar] [CrossRef] [PubMed]
  10. Raffone, C.; Gianfreda, F.; Bollero, P.; Pompeo, M.G.; Miele, G.; Canullo, L. Chairside virtual patient protocol. Part 1: Free vs Guided face scan protocol. J. Dent. 2022, 116, 103881. [Google Scholar] [CrossRef] [PubMed]
  11. Raffone, C.; Gianfreda, F.; Pompeo, M.G.; Antonacci, D.; Bollero, P.; Canullo, L. Chairside virtual patient protocol. Part 2: Management of multiple face scans and alignment predictability. J. Dent. 2022, 122, 104123. [Google Scholar] [CrossRef] [PubMed]
  12. Antonacci, D.; Caponio, V.C.A.; Troiano, G.; Pompeo, M.G.; Gianfreda, F.; Canullo, L. Facial scanning technologies in the era of digital workflow: A systematic review and network meta-analysis. J. Prosthodont. Res. 2022; ahead of print. [Google Scholar] [CrossRef]
  13. Vinci, R.; Manacorda, M.; Abundo, R.; Lucchina, A.G.; Scarano, A.; Crocetta, C.; Muzio, L.L.; Gherlone, E.F.; Mastrangelo, F. Accuracy of Edentulous Computer-Aided Implant Surgery as Compared to Virtual Planning: A Retrospective Multicenter Study. J. Clin. Med. 2020, 9, 774. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  14. Mastrangelo, F.; Battaglia, R.; Natale, D.; Quaresima, R. Three-Dimensional (3D) Stereolithographic Tooth Replicas Accuracy Evaluation: In Vitro Pilot Study for Dental Auto-Transplant Surgical Procedures. Materials 2022, 15, 2378. [Google Scholar] [CrossRef] [PubMed]
  15. Lione, R.; Cretella Lombardo, E.; Paoloni, V.; Meuli, S.; Pavoni, C.; Cozza, P. Upper arch dimensional changes with clear aligners in the early mixed dentition: A prospective study. J. Orofac. Orthop. 2023, 84, 33–40. (In English) [Google Scholar] [CrossRef] [PubMed]
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Gianfreda, F.; Bollero, P. Dental Materials Design and Innovative Treatment Approach. Dent. J. 2023, 11, 85.

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Gianfreda F, Bollero P. Dental Materials Design and Innovative Treatment Approach. Dentistry Journal. 2023; 11(3):85.

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Gianfreda, Francesco, and Patrizio Bollero. 2023. "Dental Materials Design and Innovative Treatment Approach" Dentistry Journal 11, no. 3: 85.

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