Vitamin E and Non-Communicable Diseases: A Review
Abstract
:1. Introduction
2. Metabolism
3. Serum Metabolites
4. Vitamin E Effects in Human Health and Diseases
4.1. Antioxidant Activity
4.2. Anti-Inflammatory Activity
4.3. Interaction of Vitamin E and Gut Microbiota
4.4. Vitamin E and Cardiovascular Diseases
4.5. Vitamin E and Diabetes Mellitus
4.6. Vitamin E and Asthma
4.7. Vitamin E and Cancer
5. Toxicity and Health Risk of Vitamin E
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Pathological Conditions | Reported Effect | References |
---|---|---|
Oxidative stress | Antioxidant by scavenging free radicals, especially peroxyl radicals, and singlet oxygen. | [2] |
To maintain the integrity of long-chain polyunsaturated fatty acids in the membranes of cells and thus maintain their bioactivity. Maintaining the membranes integrity by inhibiting long-chain polyunsaturated fatty acids oxidation | [10] | |
Preserving mitochondrial efficiency | [4,6,15] | |
Inflammation | Inhibition of inflammation mediators and related enzymes | [3,4,18,19] |
Dysbiosis | Modulatory effect on gut microbiota | [30,31] |
CVD | Reduction in atherosclerotic plaque formation, CVD outcomes, myocardial infraction, and ischemic stroke risks | [12,36] |
Lowering of CD36 expression | [3,12,37] | |
Elevation of blood pressure by αT or mixed tocopherols | [4] | |
Reduction in platelets coagulation and aggregation with αT or γT supplementation | [4] | |
Reduction in atherosclerosis progression with vitamin E and coenzyme Q supplementation | [4] | |
Reduction in oxidized HODE in the hearts of α-TOH-treated mice | [36] | |
αT administration causes anti-oxidative response following I/R damage | [36] | |
Protective effect of αT on mitochondrial integrity | [12,36] | |
Inhibition of COXs and 5-LOX by 13′-COOHs and αT | [3,4,7] | |
Reduction in lipids oxidation in the myocardium by αT | [36,37] | |
Reduction in CVD risk factors with vitamin E, C and L-arginine | [12] | |
Reduction in ischemic heart disease risk using vitamin E, C, and/or vitamin A | [12] | |
Reduction in apoptotic activity with vitamin E | [12] | |
Diabetes | No relationship with αT serum levels | [43] |
Lower αT plasma levels in subjects with T2DM | [44] | |
No protective effect of vitamin E supplementation | [43,44,45] | |
Protective effect against diabetes-induced complications | [46] | |
Protective effect against diabetes-induced atherosclerosis | [49,50] | |
Conflicting result about the protective effect against diabetes-induced atherosclerosis | [51] | |
Protective effect against diabetes-induced nephropathy | [53,54] | |
Protective effect against diabetes-induced retinopathy | [55,56,57,58] | |
Lower vitamin E serum levels in people with diabetes-induced retinopathy | [56] | |
Asthma | Protective effect of vitamin E maternal intake | [19,61,62] |
Protective effect of vitamin E | [19,63,64] | |
Breast cancer | Possible protective effect of vitamin E | [67] |
Inverse association with breast cancer risk only for vitamin E dietary intake in postmenopausal women | [68] | |
Inverse relationship between αT serum levels and ER+ breast cancer risk, but positive relationship with serum ẟT and conjugated γT. | [69] | |
Lung cancer | No relationship with αT serum levels | [71] |
No protective effect of vitamin E supplementation | [72] | |
Inverse relationship between αT serum basal levels and lung cancer risk | [73] | |
No protective effect of vitamin E supplementation | [73] | |
Colorectal cancer | Lower vitamin E plasma levels in subjects with colorectal cancer (for Caucasian population) | [74] |
No protective effect of vitamin E | [75,76] | |
Inverse relationship between vitamin E intake and colorectal cancer risk, but no relationship with αT serum levels | [77] | |
Prostate Cancer | Inverse relationship between αT serum levels and prostate risk, no relationship with γT | [79] |
No protective effect of αT supplementation | [80] |
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Ciarcià, G.; Bianchi, S.; Tomasello, B.; Acquaviva, R.; Malfa, G.A.; Naletova, I.; La Mantia, A.; Di Giacomo, C. Vitamin E and Non-Communicable Diseases: A Review. Biomedicines 2022, 10, 2473. https://doi.org/10.3390/biomedicines10102473
Ciarcià G, Bianchi S, Tomasello B, Acquaviva R, Malfa GA, Naletova I, La Mantia A, Di Giacomo C. Vitamin E and Non-Communicable Diseases: A Review. Biomedicines. 2022; 10(10):2473. https://doi.org/10.3390/biomedicines10102473
Chicago/Turabian StyleCiarcià, Giulia, Simone Bianchi, Barbara Tomasello, Rosaria Acquaviva, Giuseppe Antonio Malfa, Irina Naletova, Alfonsina La Mantia, and Claudia Di Giacomo. 2022. "Vitamin E and Non-Communicable Diseases: A Review" Biomedicines 10, no. 10: 2473. https://doi.org/10.3390/biomedicines10102473