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Review

Application of Smartphone Technologies in Disease Monitoring: A Systematic Review

1
School of Information Technology, Deakin University, 1 Gheringhap St, Geelong, VIC 3220, Australia
2
Institute for Physical Activity and Nutrition (IPAN), Deakin University, Burwood, VIC 3125, Australia
3
Iverson Health Innovation Research Institute, Swinburne University of Technology, Hawthorn, VIC 3122, Australia
4
Department of Information Systems and Business Analytics, Deakin Business School, 221 Burwood Highway, Burwood, VIC 3125, Australia
*
Author to whom correspondence should be addressed.
Healthcare 2021, 9(7), 889; https://doi.org/10.3390/healthcare9070889
Submission received: 20 May 2021 / Revised: 3 July 2021 / Accepted: 9 July 2021 / Published: 14 July 2021
(This article belongs to the Special Issue Emerging Technologies in Health Informatics and Management)

Abstract

:
Technologies play an essential role in monitoring, managing, and self-management of chronic diseases. Since chronic patients rely on life-long healthcare systems and the current COVID-19 pandemic has placed limits on hospital care, there is a need to explore disease monitoring and management technologies and examine their acceptance by chronic patients. We systematically examined the use of smartphone applications (apps) in chronic disease monitoring and management in databases, namely, Medline, Web of Science, Embase, and Proquest, published from 2010 to 2020. Results showed that app-based weight management programs had a significant effect on healthy eating and physical activity (p = 0.002), eating behaviours (p < 0.001) and dietary intake pattern (p < 0.001), decreased mean body weight (p = 0.008), mean Body Mass Index (BMI) (p = 0.002) and mean waist circumference (p < 0.001). App intervention assisted in decreasing the stress levels (paired t-test = 3.18; p < 0.05). Among cancer patients, we observed a high acceptance of technology (76%) and a moderately positive correlation between non-invasive electronic monitoring data and questionnaire (r = 0.6, p < 0.0001). We found a significant relationship between app use and standard clinical evaluation and high acceptance of the use of apps to monitor the disease. Our findings provide insights into critical issues, including technology acceptance along with regulatory guidelines to be considered when designing, developing, and deploying smartphone solutions targeted for chronic patients.

1. Introduction

Globally, human life expectancy has increased considerably over the years and continues to rise [1,2]. This improvement in life expectancy can be attributed primarily to the remarkable advancement in healthcare services, medical procedures, diagnostic technologies, improved living conditions, health literacy, awareness about nutrition, and other public health measures [2]. It is predicted that by 2050, the number of children under 14 years will be outnumbered by the elderly population aged over 65 years, mainly due to increased life expectancy and decreased fertility rate [1]. However, with this rise in life expectancy coupled with general advances in healthcare, we are simultaneously witnessing a rise in chronic conditions such as diabetes and cardiovascular diseases [3]. Furthermore, it is estimated that around 15% of the world’s population is living with some form of disability [4,5]. Overall, in 2016, the major causes of death (54%) worldwide were due to non-communicable diseases (e.g., ischaemic heart disease, stroke, chronic obstructive pulmonary disease, Alzheimer disease and other dementias, cancers (trachea, bronchus, and lung), and diabetes mellitus) [6].
Advancements in knowledge, science, and technology have been critical in curbing the global mortality rate and prolonging life expectancy [7]. Moreover, the progress in data science, such as big data analytics and cloud technologies, has enabled the development of personal life expectancy prediction models, which could be used to calculate health indexes from massive datasets collected over the years [8]. In recent times, the widespread application of Information and Communication Technologies (ICTs) in the health sector has resulted in significant improvements in the healthcare delivery system, such as promoting patient-centred healthcare, improving quality of care, and educating health professionals and patients [9]. ICTs, including digital technologies for electronic capture, storage, processing, and information exchange, have been used in chronic disease prevention and management [9,10], and are used in chronic disease monitoring and surveillance such as to track cancer cell progression (e.g., SO2 metabolism) [11], predict the risk of diabetic complications (e.g., foot ulcer) [12], and remote monitoring and training of stroke and Parkinson’s patients [13]. ICTs are also used as self-management tools to assist patients with diabetes [14], cancer [15], and dementia [16]. Moreover, with the constant growth and evolution of ICTs, a vast amount of information related to patient care is generated; hence there is a need for decision support systems to provide knowledge, models, and data processing tools in assisting medical practitioners to take appropriate decisions when treating patients [17]. Nevertheless, the slow progression and subtle nature of some chronic disease symptoms question the capacity of ICT monitoring devices to detect the acute episodes of these conditions in real-time [18].
Smartphone technology, including apps [19] and app integrated wearable sensors [20], offers further chronic disease management potential. Moreover, the technological capacity, popularity, availability, and increased smartphone ownership globally, including in developing nations, promotes the smartphone as an attractive tool to assist patient self-management, continuous symptoms and vital sign monitoring, and communication between patients and physicians [21,22]. Furthermore, chronic disease management apps are beneficial in improving patients’ clinical outcomes and assisting in providing necessary medical care [22]. Additionally, apps integrated with built-in smartphone sensors and wearable external sensors can capture numerous health parameters to deliver personalised healthcare solutions [23,24]. Because apps have the potential to capture data using the various smartphone sensors, they are used for various forms of health monitoring, including heart, eye, skin, mental health and activity monitoring, respectively, implying a vital need for regulatory policies for the development of smartphone-based healthcare systems [25].
Patients with chronic conditions are often dependent on life-long healthcare systems that involve different stakeholders, including healthcare professionals, specialised care centres, primary care providers, and community-based services [26,27]. However, the inconsistent implementation of quarantine policies due to COVID-19 has limited access to hospital care for patients with chronic diseases, created uncertainty over their disease status, and accentuating their emotional situation [28]. Furthermore, COVID-19 highlights the imperative need for countries to ensure an equitable and accessible healthcare system to meet people’s emerging health needs, such as people-centred, affordable, non-discrimination and equitable care, tailored to the individual’s needs [29].
The literature contains reviews on the effectiveness of technology such as smartphone applications (app), and wearable sensors, for chronic disease management. A recent systematic review found that technology could facilitate adherence to treatment of chronic diseases using simple messages and alerts [30]. However, another systematic review observed a paucity of data on the effectiveness and use of mobile and web-based apps that support self-management and transition in adolescents with chronic diseases [31]. Other reviews specifically looked at the effectiveness of wearable sensors in adults with a chronic cardiometabolic disease [32] and chronic kindly disease [33]. We are unaware of any recent literature review which has evaluated the use of app integrated smartphone technology in monitoring and managing chronic disease in adult populations, irrespective of their medical condition. Hence, this review aims to evaluate the accuracy and technology acceptance of app integrated smartphone technologies with standard clinical procedures among adults living with chronic conditions.

2. Materials and Methods

We followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to organise the review [34]. Since this review is based on peer-reviewed studies for which primary investigators obtained informed consent, ethics approval was unnecessary [35].

2.1. Protocol

This review is undertaken due to the unprecedented situation which has arisen due to COVID-19 and hence it was not pre-registered in PROSPERO.

2.2. Data Sources and Search Strategy

The studies were identified through a comprehensive literature search in the online database, including Medline complete, Web of Science, Embase, and Proquest. Initial literature search focused on technologies for disease monitoring and management using a combination of key search terms which include ‘technology OR computer OR tablet OR mobile phone OR smartphone OR internet OR app’, AND ‘disease OR illness OR sickness OR condition OR disorder OR health’, AND ‘monitoring OR tracking OR evaluation OR tool’. We included studies published in English. Although several apps are developed and deployed for chronic disease management [36,37,38], there is a paucity of evidence for the effectiveness and use of mobile and Web-based apps in chronic disease management [31,39]. Consequently, with the overwhelming numbers and types of digital solution, the World Health Organisation (WHO) has recommended their evaluation of in research settings to rigorously analyse the benefits, harms, acceptability, feasibility, resource use and equity considerations of digital health interventions before deployment [39]. Hence, we have considered studies evaluated in research settings and published exclusively in research journals. The final searches were based on the Embase search strategy (Table S1), and searches were adapted as appropriate to the specifications of the databases [40].

2.3. Study Selection Criteria

A set of selection criteria were used to narrow down the selection of articles that would fulfil the main objectives of the systematic review (Table 1). The search is limited to a timeframe between January 2010 and September 2020 matching the period of disruptive innovations in wireless technologies such as Bluetooth, ZigBee, and 4G, and app development for health applications (mHealth) [38,41,42].

2.4. Study Selection Process

We followed a step-by-step selection process to identify the relevant articles (Figure 1). The obtained citations were imported into the reference management software EndNote and duplicates removed. We applied the selection criteria to screen the articles and to select studies relevant to the objective of this review.

2.5. Data Extraction

One reviewer independently evaluated the titles and abstracts of all records identified in the initial database search [43]. The reviewer then assessed the full-text for eligibility in line with the inclusion criteria [43]. Data were extracted regarding the app and integrated wearable devices, the questionnaire used, and monitoring duration. The outcomes of each study were considered. The acceptance of technology by the various stakeholders was also extracted. Additionally, study characteristics, including study type and participant types, were also extracted.

2.6. Risk-of-Bias Assessment

The studies considered in this review had used an app to monitor and manage the chronic condition. We performed risk assessment at the outcome level based on heterogeneity and availability of data [34]. Two dimensions define risk, considering the probability of an event occurring that could lead to harm and the severity of the harm likely to follow that event [45]. Moreover, due to the lack of a clinically relevant risk assessment framework for medical apps [45], we have used the Two-dimensional “App-space” for risk assessment of mobile medical apps as an appropriate risk assessment tool. The Two-dimensional “App-space” categorises types of risk variable as inherent to the app, including specific risk variables such as intended functions, inaccurate or out of date content, the complexity of the task supported by the app, and lack of feedback or failsafe mechanism, and as external factors depending on the context of app use including specific risk variables such as app user, inappropriate app usage, inadequate user training, likelihood of errors being detected, and app usage factor [45]. Nevertheless, increases in risk with increase in app functionality and a risk score corresponding to the magnitude of this risk are assigned for each factor [45]. For example, apps used for BMI calculations are at negligible risk compared to apps used as clinical decision support tools, which are at high risk [45].

2.7. Analysis of Selected Studies

Primary outcomes for the research articles and their statistically significant value where applicable are represented. This has enabled a critical review of each study’s results and identification of consistencies in their functional capability and differences in applicability. The studies have considered that the critically significant cut-off point of the results, as designated by p-values, were at the level of α < 0.05.

3. Results

3.1. Search Results

We retrieved a total of 1919 articles for the applied search key from the database. Upon removing duplicates, there were 1246 articles for full-text review. Further, we screened the electronically obtained titles and abstracts for relevance of selection criteria. The selected 175 articles were further accessed, assessed, and matched with the study’s objectives. At each level of article screening, we excluded review articles such as systematic reviews [46], surveys [47], literature reviews [48], protocols [49] and similar articles. We further screened for non-human subjects such as battery health monitoring [50], structural health monitoring [51], pipe structural health monitoring [52], and similar articles, including the use of health information technology to calculate mortality risks [53]. Additionally, since we focused on chronic disease monitoring and management, we discarded studies focusing on evaluation and development of research tools, such as on assessing the quality of health apps [54], gauging the effectiveness of apps using a paper-and-pencil survey [55], evaluating patient attitudes toward mobile phone-based health monitoring [56], development of prototypes not evaluated on humans [57], and other such studies. Likewise, we eliminated studies focused on the economic evaluation of health technologies [58,59], undertaken amongst children, i.e., aged below 18 [60,61,62], and undertaken among less than fifteen participants [63]. Finally, we included five papers in this review and Table 2 represents the characteristics of the included studies. Table S2 represents the summary of findings.

3.2. Search Results

The app is used as the primary source to capture data [64,65,66,67,68], in addition to wearable sensors [64,67] and questionnaires [64,65,66]. The sample size of the studies varied between 16 [68] and over 900 [65]. The studies used variable lengths of time to monitor the interventions in home settings such as eight weeks [65], twelve weeks [64,66], and 24 weeks [68], whereas a single session observation/monitoring to evaluate the accuracy of wearable smart clothing system for cardiac health monitoring was conducted in the clinical setting [67]. The studies included both experimental [65,66,67] and observational [64,68] types, and were conducted in multiple international locations including two studies in Asia [66,67], three studies in Europe [64,68,69], and a study in the United States of America [65].

3.3. Risk Assessment

The risk associated with the medical apps at app level and external (contextual) level is evaluated (Table 3) [45]. At app level, the risk of apps used to monitor terminal cancer patients [64], and heart failure (HF) patients [67] remotely, and to regulate the stress of borderline personality disorder (BPD), were at high risk. This high risk is due to any programming error which could cause inherently dangerous medical functionalities resulting in an associated risk to the patient [45]. Moreover, since the studies had not detailed the features of apps [64,65,66,67,68], we could not access the risk associated with the app content and feature such as availability of feedback mechanism [45].
The risk associated with external factors was minimal for the app user and there was little inappropriate app usage in all the considered studies, since the app was used in research settings by the intended users. However, the risk associated with other factors varied. For example, although all the studies had recruited proficient smartphone participants and demonstrated the system’s functionalities [64,65,66,67,68], the users lacked the knowledge to discern the accuracy of the content delivered through the app, increasing the associated risk [65,68]. Likewise, the risk of detecting errors is high in the app used amongst terminally ill cancer patients with a life expectancy of less than a year, due to the criticality and necessity of accurate data capture [64]. Furthermore, the study undertaken to evaluate an app’s effectiveness for eating disorder management is available in the app store to be downloaded by the public, having a very high app usage factor and increasing risk, since a faulty app could affect comparatively many users [65].
The risk is high in apps used for disease monitoring including for monitoring of cancer patients in palliative care [64], cardiac health monitoring of HF patients [67], and monitoring and reducing aversive tension in BPD patients [68]. In contrast, a lower risk is involved in using apps for disease management, including the treatment of eating disorder [65] and weight management [66].

3.4. Disease Monitoring and Management

Disease is an interruption, cessation, or disorder of body functions, systems, or organs [70]. The cause of disease varies; pathogens, which are invading agents, cause infectious disease, whereas unhealthy lifestyle choices, environmental factors, and genetic disorders can cause non-infectious disease [70]. Although chronic disease may be less severe, frequent/continuous medical attention is needed to overcome health impairments limiting daily living activities [70]. Screening for chronic disease could prevent onset [71]. However, after onset, there is an imperative need to manage and monitor the disease [72,73]. Disease monitoring involves the continuous collection of data to assess the status of health and disease conditions [73], whereas the disease management approach equips the individual patient with the information and skills necessary to act as their own self-managers, thereby maintaining optimal health [72]. Accordingly, we have classified the studies into disease monitoring [64,67,68] and disease management [65,66] depending on the objectives and functionalities of the study. Figure 2 represents the classification and functionalities of the apps, and participant characteristics.

3.4.1. Disease Monitoring

The feasibility of remote monitoring using an app integrated wearable sensor (bracelet worn on the upper arm) was assessed among terminal cancer patients who had an estimated survival period of between 8 weeks and 12 months to anticipate and prevent the rapid deterioration of health conditions, eventually minimising unplanned readmissions or emergency hospital visits [64]. In addition to the sensor captured data including resting heart rate, resting heart rate variability, and speed of steps, the participants filled-in daily the app-based Visual Analog Scale (VAS) questionnaire for pain and distress, and on analysing the responses a moderately positive correlation between mobile health features extracted from sensor signals and daily VAS ratings (r = 0.6, p < 0.0001) was found [64]. On the contrary, participants were interviewed over the phone weekly to record response for the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) and no significant correlation between mobile health features and the individual QLQ-C30 scores was found [64]. Furthermore, patients who had an emergency hospital visit (n = 11, 36.7%) during the study period exhibited an increased resting heart rate, decreased heart rate variability, and a trend towards increased step speed when compared with patients not having an emergency hospital visit [64].
To provide early risk warnings, i.e., to predict the left ventricular ejection fraction (LVEF) among HF patients, a multi-channel mechano-cardiogram (MCG) wearable smart clothing system for cardiac health monitoring integrated with hardware, firmware, app, and wireless design features was designed and evaluated in clinical settings [67]. Although the study duration was for a short time, an accuracy rate of up to 96% for predicting cardiac functions’ abnormality, such as HFs, was observed [67].
There is an essential need to regulate inner tension of BPD sufferers since they could exhibit adverse self-harming behaviours ranging from self-cutting to burning and banging the head against the wall, at any time of the day [68]. Corresponding to the current aversive tension level recorded in the app by the participants, the app suggested random exercises between 3 and 8 min, played in audio/video format for the patient to complete [68]. There was a decline in the level of stress (Initial: (5.95 ± 3.13) points: (Final: 2.83 ± 2.36) points (paired t-test = 3.18; p < 0.05)), signifying that apps can be efficient in reducing aversive tension [68].

3.4.2. Disease Management

The potential of apps in managing eating disorders, which can severely impact psychological, physical, and social functioning amongst participants (n = 959) categorised into a standard group (n = 458) and intervention group (n = 501), was evaluated [65]. The standard group participants used the standard app, which functions via a cognitive behavioural therapy concept [65]. In contrast, the intervention group received a tailored version of the app that included algorithmically determined clinical content, explicitly aligned to the user [65]. The self-reported Eating Disorder Examination Questionnaire [EDE-Q] score determined the magnitude of the eating disorder in each participant, and at week four from study commencement participants in the intervention group (51.5%; 227/441) as well as in the standard group 46.2% (156/338) achieved a clinically meaningful change in EDE-Q score, i.e., a decrease in the EDE-Q global score by a 0.5 SD [65]. Furthermore, at week eight, 61.6% of intervention group participants (180/292) and 55.4% of standard group participants (158/285) achieved a clinically meaningful EDE-Q score [65]. However, the rate of remission on the EDE-Q at eight weeks was significantly greater in the intervention group (d = 0.22; p ≤ 0.001) when compared with the standard group [65].
Participants who were overweight and obese but willing to act on weight loss participated in a 12-week weight management program delivered through a collection of apps [66]. Apps with diverse functionalities such as counting daily steps walked and messaging applications for providing food and beverage, along with easy exercises as multimedia content and photos of the food consumed, were collectively used to assist the participants in weight loss [66]. The study observed a significant decline in the mean weight and waist circumference of the participants (p = 0.008, p < 0.001) from baseline (72.2 ± 10.4 kg, 92.1± 10.1 cm) during post-intervention (week 6: 71.6 ± 10.8 kg, 89.9 ± 9.9 cm) and follow-up (week 12: 71.4 ± 11.0 kg, 87.8 ± 10.7 cm) periods, respectively [66]. Furthermore, providing weekly tailored interventions could favourably influence behavioural factors such as healthy eating and physical activity (p = 0.002), eating behaviours (p < 0.001), dietary intake pattern (p < 0.001), mean body weight (p = 0.008), mean BMI (p = 0.002), and mean waist circumference (p < 0.001) [66]. Additionally, other lifestyle changes such as decreased consumption of sugar-sweetened beverages (p < 0.001) and increased frequency of taking stairs (p = 0.002) could have influenced the positive outcome in weight management [66]. Furthermore, a marked increase in the rate of obesity was observed among participants aged 30 years and older, with the highest rate being in those between 45 and 59 years of age (51.8%) [66].

3.5. Technology Acceptance

There is a need to perform usability testing in a realistic scenario and environment to evaluate ease of use and usefulness of the solution and to determine system acceptability [74]. Accordingly, studies have used various methods such as customised questionnaires [64], duration of app usage [68], and the Technology Acceptance Model (TAM) [67] to evaluate technology acceptance (Table 4). The majority (76%) of the terminal cancer patients using wearable sensors assessed for usability of app and comfort of the wearable sensor in a real-life scenario in a 12 weeks study period had a positive experience with the monitoring system [64]. In contrast, a study considered the extended time duration of the app usage, such as the number of sessions per week (11.95 ± 9.75), frequency of recordings per day (1.21 ± 1.12), and overall time exposed to the device (318.1 ± 166.7 min) per subject, with a mean session of around 2.73 (±4.43) minutes as the indicator for user satisfaction [68]. Furthermore, a TAM-based path analysis confirmed perceived ubiquity and perceived benefits to be key determinants of user acceptance of wearable sensors [67]. The participants in this study show a positive user attitude toward of using wearable sensors.

3.6. Regulatory Agencies

The revolution in smartphone technologies, direct-to-consumer genetic testing, crowd-sourced information, and big data have enabled researchers, including independent researchers, citizen scientists, patient-directed researchers, do-it-yourself (DIY) researchers, and self-experimenters, in facilitating the development of mHealth systems [75]. On the other hand, the easy access to mHealth systems increases the potential of unregulated health research [75], which could be beneficial but could also pose risks to the users involving accuracy, privacy, and safety [76]. Moreover, there is an ambiguity regarding when a medical app could be considered as a formal medical device [45]. Hence there is an imperative need for governments to regulate the development and deployment of mHealth systems through competent regulatory agencies [75,76].
The considered studies had used apps to remotely monitor patients through wearable sensors [64,67], and to assist in the participant’s health and wellbeing [65,66,68]. According to Two-dimensional “App-space” for risk assessment of mobile medical apps, it is mandated that apps that assist in clinical decision support should undergo formal assessment and regulation by a professional and government body such as the Food and Drug Administration (FDA) and Medicines and Healthcare Products Regulatory Agency (MHRA) [45]. Nevertheless, disease monitoring apps including for monitoring of cancer patients in palliative care [64], cardiac health monitoring of HF patients [67], and monitoring and reducing aversive tension in BPD patients [68], have not sought approval for use by professional and government bodies. However, they could pose a significant risk to patients due to a combination of inherent complexity, functionality, and potential to cause health hazards if misused [45]. Furthermore, apps assisting in functionalities, including diagnostic support, patient decision making, and medical calculators, are subjected to formal assessment by local health organisations [45]. Accordingly, studies evaluating disease management, including in treating eating disorders [65] and weight management [66], have sought local health organisation approval.

4. Discussion

The studies displayed a skewed representation of male [64,67] and female [65] participants. A study to evaluate the app’s effectiveness in weight loss [66] and to regulate the stress of BPD patients [68] did not consider male participants but found the intervention to be effective. However, there is a void in understanding the interventions’ impact amongst male participants [66,68]. Moreover, the exploration of gender-based intervention outcomes could help conceptualise the role of gender in addressing its relationship with intervention outcomes [77].
The increase in the complexity of app functionality proportionately increases the possibility of harm due to usage [45]. Although the apps used were for critical healthcare needs, including disease monitoring [64,67,68] and disease management [65,66], no formal assessment and regulation by professional and government bodies were undertaken. Currently, there are efforts to formulate guidelines in prescribing apps and outline key issues to enable app dissemination in healthcare [78]. However, since apps are developed and shared more quickly than they can be assessed for efficacy, safety, and security, an unwarranted situation to for patients and clinicians in which the challenge of distinguishing helpful from harmful apps is created [79]. Additionally, currently, there are a lack of clear and accepted standards for the development (planning, requirement analysis and research, design, and application testing) of healthcare apps which could pose different risks to developers, providers, patients and the public [80]. Consequently, there is a necessity to formulate guidelines for the development of apps to mitigate risks, including clinical, privacy, and economic risks [80].
The advancement in smartphone technology and the ability to integrate with various adjunct technologies has enabled apps to be developed and deployed in health and clinical practices [81]. Studies used apps which were freely available [65,66,68], and had been developed with a potential to be integrated with wearable sensors to monitor targeted activities [64,67]. Apps used in home settings have assisted in the improvement of health and wellbeing of the participants [65,66,68], and were found to be feasible in remotely monitoring patient’s vital organs using integrated wearable sensors [64]. Furthermore, although an app to assist in eating disorders is freely available globally via the Google Play (Android) and iTunes (iPhone) app stores, the study considered participants from a selected geographical location and observed that underserved individuals with eating disorder symptoms might benefit clinically from a self-help app [65]. These observations suggest that apps could play a vital role in achieving clinically meaningful improvement in patients, irrespective of the economic status of the country, due to cost-effectiveness and the ability to reach more individuals [65].
Cancer was the second leading cause of death globally in 2018 [82]. A study found that it is feasible to remotely monitor terminally ill cancer patients with an app-integrated wearable sensor system [64]. Nevertheless, the detection of cancer at an early stage could drastically reduce the risk [83]. However, screening faces hindrance due to barriers such as insufficient knowledge about cancer, the purpose of screening [84], emotional aspects [85], and a variety of personal, practitioner, test-related and logistical factors [86]. Furthermore, the restrictions enforced in hospital visits globally due to COVID-19 have forced cancer screening programmes to halt, risking the chances of early diagnosis [87]. In contrast, the use of smartphone-based telemedicine has enabled palliative care physicians to follow-up on cancer patients during the COVID-19 pandemic period and enabling symptom management, restocking of opioid medications, and providing information regarding oncological treatments requiring consultation with other departments [88].
Smartphone-based telemedicine has good prospects in the future of healthcare delivery systems amongst cancer patients, especially among those unable to visit hospitals regularly due to a weakened immune system [88]. There is a scope for smartphone integrated technologies in biomedical image analysis including detection for skin/breast cancer [83,89,90], cancer pain management [91], treatment of breast cancer [92], and dissemination of information to help cancer patients in non-clinical settings [93]. Although recently several apps have been developed for cancer management, a study revealed that only 3% of apps (n = 4/123) had been evaluated by healthcare providers [94]. However, the advancement in smartphone technology creates an opportunity to capture continuous real-time data benefitting cancer management [95]. Hence, there is a need for multidisciplinary collaboration to develop mobile sensing frameworks that could deliver timely and personalised support to patients through remote monitoring of their health in order to improve clinical oncology outcomes [95].
COVID-19, a respiratory illness caused by a highly contagious virus with the potential for fatal outcomes to specific risk groups, is currently a global public health concern [96]. Given the high infectivity rate of the virus, the growing demand for telehealth and the monitoring of infected patients are on the rise [97]. A study observed that the risk factors for weight gain during self-quarantine are inadequate sleep, snacking after dinner, lack of dietary restraint, eating in response to stress, and reduced physical activity [98]. This study observed that apps could effectively alleviate mental stress and assist in eating disorder and weight management [65,66,68]. Hence, there is scope for apps and integrated technologies to function as useful tools to maintain individual’s health and wellbeing during this pandemic period. Furthermore, it is premature to precisely predict the physical, psychological, neuropsychological and social impacts of COVID-19 [99]. The study observed that app-integrated wearable sensors have the potential to remotely monitor vital readings, irrespective of the severity of the disease and of age [64,67]. Furthermore, a technologically dependent monitoring system could have the potential for remote and continued monitoring and management of patients with/recovered from COVID-19 to assist healthcare practitioners [100]. Hence, this unprecedented situation calls for technology [101] and a multidisciplinary research approach to monitor recovered patients [102].
Technology acceptance is evaluated using different methodologies [64,67,68], though a few studies have excluded this [65,66]. The primary concern expressed by around 50% of terminally-ill cancer patients regarding withdrawal from the study were due to the handling of devices being too cumbersome [64]. Moreover, studies have recruited participants who were proficient smartphone users [64,65,66,68]. Therefore, while developing a healthcare system with various ICT components, it must be secure, reliable, socially acceptable, and above all be usable by various stakeholders, i.e., the system must support different user groups to interact effectively and easily, and also assist older people in accessing the system effortlessly [74]. Furthermore, there is an imperative need to evaluate the system using established models such as TAM to examine the significance of the outcomes in a global setting.

4.1. Implications for Practice

The reviewed articles suggest that apps could be used to monitor and manage chronic diseases with accuracy on par with that of the current gold standards [64,65,66,67,68]. Furthermore, in conjunction with apps, wearable sensors are also used to capture real-time recordings of vital signs of patients and have assisted in predicting health and wellbeing [64,67]. In the current situation, apart from phone calls, the usage of apps and wearable sensors could assist in making well-informed decisions to maintain health [97,103].
There are clinical, privacy, and economic risks involved with the use of healthcare apps [80]. Furthermore, there is a lack of clear and accepted standards for the development of healthcare apps which could pose different risks to developers, providers, patients and the public [80]. Moreover, there is ambiguity regarding when a medical app can be considered as a formal medical device [45]. Hence, there is an imperative need for governments to regulate the development and deployment of mHealth systems through professional and/or government agencies [75,76].

4.2. Implications for Research

The findings of this research have implications for future technology design and development. Despite multiple health apps being available to support the health and wellbeing of individuals, there is a paucity in knowledge of app credibility. For example, are the readings verified against clinical standards, are the devices medically conformed, is the transferred information secure and private, and was the app evaluated in a research study and among different populations [37,38]? Our findings would be of assistance to health practitioners for the design and deployment smartphone technologies in clinical practice. For example, apps integrated with wearable sensors to monitor targeted activities amongst terminal cancer patients and HF patients can monitor vital signs continuously in real-time irrespective of the disease severity and participants age [64,67]. Developing smartphone integrated wearable sensors could help health practitioners monitor their chronic patients continuously, in real-time, but remotely. Likewise, this finding would also help individuals in self-managing behavioural factors such as physical activity and eating habits using apps with research evaluation, which could help them stay physically and mentally fit. For example, apps could effectively alleviate mental stress and assist in eating disorder and weight management [65,66,68]. Hence, individuals could benefit from apps evaluated in research settings to self-manage their health. Moreover, there are research prospects in undertaking systematic literature reviews considering factors such as development, approval from regulatory agencies, evaluation in research settings and other factors, to recommend apps as healthcare assistive tools during the pandemic, and in developing countries lacking infrastructure.

Future Research Directions

Healthcare practitioners prescribe apps as a useful self-management tool for patients [104]. This review highlighted that apps could be used to monitor and manage chronic diseases with accuracy on a par with that of the current gold standards [64,65,66,67,68]. With advancements in technology, big data analytics can improve outcomes for patients in providing evidence-based healthcare solutions [105,106]. It is anticipated that health parameters recorded from the smartphone may increase the prospect of analysing vital recordings to offer well-informed personalised healthcare solutions [107]. Moreover, the application of machine learning, which is a branch of artificial intelligence using a large amount of digital data, could extract new knowledge that could help healthcare practitioners make well-informed decisions [108]. However, while developing ICT based healthcare systems, in addition to the requirements of the stakeholders, the privacy of users and security of the data must be considered [108]. Furthermore, it is foreseen that mobile technologies, data analytics, Internet of Things (IoT), and 5G connectivity could enhance the healthcare system by providing evidence-based, personalised healthcare solutions that are capable of handling increased velocity, variety, and volume of healthcare data with privacy and security in real-time [107]. Hence, there are research prospects for the design, development and deployment of integrated healthcare systems with mobile technologies, data analytics, and IoT.
Diabetes patients constituted one-third of COVID-19 infected cases, and mortality was high and was independently associated with glycaemic control and body mass index (BMI) in addition to other complications, including CVD and renal complications [109]. Moreover, diabetes independently increases the adverse impacts of COVID-19 with modifiable factors (e.g., HbA1c), having a significant but modest impact compared with comparatively static factors (e.g., race and insurance), indicating an urgent and continued need to mitigate severe COVID-19 risk in this community [110]. With COVID-19 as an on-going crisis, the risk is high among diabetes patients of facing health deterioration due to poor lifestyle and risk of mortality if infected with COVID-19. Developing integrated smartphone systems to monitor and manage diabetes patients is a current global need and would assist diabetes patients, their family and caregivers, and their health practitioners.
Symptom severity associated with COVID-19 ranges from a mild common cold-like illness to severe viral pneumonia leading to acute respiratory distress syndrome that is potentially fatal; complications related to severe COVID-19 also include, but are not limited to, multi-organ failure, septic shock, and blood clots [99]. Although mHealth provides several benefits to healthcare practitioners due to its sophisticated tools, only reliable and valid solutions should be included in medical practice [111]. Despite the many health apps available, there is a paucity of knowledge regarding app credibility [37,38]. Hence, a literature search to discover potential health consequences due to the virus infection, changes and restrictions in lifestyle, health and wellbeing, social gathering and disease screening, monitoring, and managing technologies currently available would be of assistance to the healthcare community and all adults globally, including COVID-19 patients.

4.3. Limitations of This Survey

The review reports only on a small part of the disease prevention process, although technology has found widespread application in disease prevention and monitoring. We have exclusively considered articles published in research journals, following the WHO guidelines in selecting studies undertaken in research settings. However, this has resulted in excluding grey literature and could have incurred publication bias. Although studies have observed that it is feasible to monitor and manage disease using app and integrated technologies [64,65,66,67,68], the results should be considered cautiously due to limitations such as small sample size [64,66,67,68], absence of consideration of gender [66,68], and being conducted in a single geographical location [64,65,66,67,68]. Furthermore, one reviewer performed article screening and data extraction, which could present a possibility of bias [43]. The heterogeneity of the data and the lack of standard models such as TAM to evaluate the user perception of the information system have also restricted us in conducting this meta-analysis. However, these studies’ findings could be extended to a large sample size, including male and female participants, to validate the findings’ accuracy.

5. Conclusions

We found a significant relationship between app use and standard clinical evaluation in disease monitoring and management. Furthermore, app integrated disease monitoring technologies have received high acceptance amongst patients. Although the apps used were for critical healthcare needs, including disease monitoring and management, no formal assessment and regulation by professional and government bodies was undertaken. Hence, our findings provide insights into critical issues, including technology acceptance and regulatory guidelines that must be considered when designing, developing, and deploying smartphone solutions targeted at chronic patients.

Supplementary Materials

The following are available online at https://www.mdpi.com/article/10.3390/healthcare9070889/s1. Table S1: Embase search strategy; Table S2: Study objectives and outcomes.

Author Contributions

J.C.M. designed, acquired and analysed the literature and was a major contributor in writing the manuscript. S.A. conceptualised and substantively revised the manuscript. S.M.S., N.W. and L.N. substantively revised the manuscript. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Institutional Review Board Statement

Not applicable.

Informed Consent Statement

Not applicable.

Data Availability Statement

Source data for all figure(s) and number(s) are provided with the paper and Supplementary Materials.

Conflicts of Interest

The authors declare no conflict of interest.

References

  1. World Health Organization. Global Health and Aging, 2011. Available online: https://www.who.int/ageing/publications/global_health/en/ (accessed on 1 July 2020).
  2. Roser, M.; Ortiz-Ospina, E.; Ritchie, H. Ourworldindata.org: Life Expectancy, 2013. Available online: https://ourworldindata.org/life-expectancy (accessed on 1 July 2020).
  3. Wickramasinghe, N.; John, B.; George, J.; Vogel, D. Achieving value-based care in chronic disease management: Intervention study. JMIR Diabetes 2019, 4, e10368. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  4. World Health Organization. Disability and Health, 2011. Available online: https://www.who.int/news-room/fact-sheets/detail/disability-and-health (accessed on 1 July 2020).
  5. Kostanjsek, N. Use of the International Classification of Functioning, Disability and Health (ICF) as a conceptual framework and common language for disability statistics and health information systems. BMC Public Health 2011, 11, 6. [Google Scholar] [CrossRef] [Green Version]
  6. World Health Organization. The Top 10 Causes of Death, 2018. Available online: https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death (accessed on 1 July 2020).
  7. Cutler, D.; Deaton, A.; Lleras-Muney, A. The determinants of mortality. J. Econ. Perspect. 2006, 20, 97–120. [Google Scholar] [CrossRef] [Green Version]
  8. Kang, J.; Adibi, S. Systematic predictive analysis of personalized life expectancy using smart devices. Technologies 2018, 6, 74. [Google Scholar] [CrossRef] [Green Version]
  9. Rouleau, G.; Gagnon, M.P.; Cote, J. Impacts of information and communication technologies on nursing care: An overview of systematic reviews. Syst. Rev. 2015, 4, 75. [Google Scholar] [CrossRef] [Green Version]
  10. Gutierrez, M.A.; Moreno, R.A.; Rebelo, M.S. Information and communication technologies and global health challenges. In Global Health Informatics; Heimar, M., Massad, E., Gutierrez, M.A., Rodrigues, R.J., Sigulem, D., Eds.; Academic Press: Cambridge, MA, USA, 2017; pp. 50–93. [Google Scholar]
  11. Zhang, W.; Huo, F.; Cheng, F.; Yin, C. Employing an ICT-FRET integration platform for the real-time tracking of SO2 metabolism in cancer cells and tumor models. J. Am. Chem. Soc. 2020, 142, 6324–6331. [Google Scholar] [CrossRef]
  12. Naemi, R.; Chockalingam, N.; Lutale, J.K.; Abbas, Z.G. Predicting the risk of future diabetic foot ulcer occurrence: A prospective cohort study of patients with diabetes in Tanzania. BMJ Open Diabetes Res. Care 2020, 8, e001122. [Google Scholar] [CrossRef]
  13. Rydmark, M.; Broeren, J.; Jalminger, J.; Johansson, L.-Å.; Johanson, M.; Ridderstolpe, A. Remote communication, examination, and training in stroke, Parkinson’s, and COPD care: Work in progress testing 3D camera and movement recognition technologies together with new patient-centered ICT services. Altern. Med. Res. 2017, 9, 411–417. [Google Scholar]
  14. Shibuta, T.; Waki, K.; Tomizawa, N.; Igarashi, A.; Yamamoto-Mitani, N.; Yamaguchi, S.; Fujita, H.; Kimura, S.; Fujiu, K.; Waki, H.; et al. Willingness of patients with diabetes to use an ICT-based self-management tool: A cross-sectional study. BMJ Open Diabetes Res. Care 2017, 5, e000322. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  15. Kondylakis, H.; Bucur, A.; Crico, C.; Dong, F.; Graf, N.; Hoffman, S.; Koumakisa, L.; Manentic, A.; Mariasa, K.; Mazzocco, K.; et al. Patient empowerment for cancer patients through a novel ICT infrastructure. J. Biomed. Inform. 2020, 101, 103342. [Google Scholar] [CrossRef] [PubMed]
  16. Yamamoto, H.; Yokokohji, Y.; Ishihara, T. Practicality assessment of the improved ICT-based dementia care mapping support system. Am. J. Alzheimers Dis. Other Demen. 2020, 35, 1533317520935716. [Google Scholar] [CrossRef]
  17. Moreira, M.W.L.; Rodrigues, J.J.P.C.; Korotaev, V.; Al-Muhtadi, J.; Kumar, N. A comprehensive review on smart decision support systems for health care. IEEE Syst. J. 2019, 13, 3536–3545. [Google Scholar] [CrossRef]
  18. Ohta, R.; Yoshinori, R.; Sato, M.; Maeno, T. Challenges of using ICT regarding acute conditions in rural home care: A thematic analysis. J. Interprofessional Educ. Pract. 2020, 20, 100349. [Google Scholar] [CrossRef]
  19. Lee, J.A.; Choi, M.; Lee, S.A.; Jiang, N. Effective behavioral intervention strategies using mobile health applications for chronic disease management: A systematic review. BMC Med. Inform. Decis. Mak. 2018, 18, 12. [Google Scholar] [CrossRef] [Green Version]
  20. Kamei, T.; Kanamori, T.; Yamamoto, Y.; Edirippulige, S. The use of wearable devices in chronic disease management to enhance adherence and improve telehealth outcomes: A systematic review and meta-analysis. J. Telemed. Telecare 2020. [Google Scholar] [CrossRef] [PubMed]
  21. Hamine, S.; Gerth-Guyette, E.; Faulx, D.; Green, B.B.; Ginsburg, A.S. Impact of mHealth chronic disease management on treatment adherence and patient outcomes: A systematic review. J. Med. Internet Res. 2015, 17, e52. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  22. Kwan, Y.H.; Ong, W.J.; Xiong, M.; Leung, Y.Y.; Phang, J.K.; Wang, C.T.M.; Fong, W. Evaluation of mobile apps targeted at patients with spondyloarthritis for disease monitoring: Systematic app search. JMIR mHealth uHealth 2019, 7, e14753. [Google Scholar] [CrossRef] [PubMed]
  23. Baxter, C.; Carroll, J.A.; Keogh, B.; Vandelanotte, C. Assessment of mobile health apps using built-in smartphone sensors for diagnosis and treatment: Systematic survey of apps listed in international curated health app libraries. JMIR mHealth uHealth 2020, 8, e16741. [Google Scholar] [CrossRef]
  24. Wattanapisit, A.; Teo, C.H.; Wattanapisit, S.; Teoh, E.; Woo, W.J.; Ng, C.J. Can mobile health apps replace GPs? A scoping review of comparisons between mobile apps and GP tasks. BMC Med. Inform. Decis. Mak. 2020, 20, 5. [Google Scholar] [CrossRef] [Green Version]
  25. Majumder, S.; Deen, M.J. Smartphone sensors for health monitoring and diagnosis. Sensors 2019, 19, 2164. [Google Scholar] [CrossRef] [Green Version]
  26. De Regge, M.; de Pourcq, K.; Meijboom, B.; Trybou, J.; Mortier, E.; Eeckloo, K. The role of hospitals in bridging the care continuum: A systematic review of coordination of care and follow-up for adults with chronic conditions. BMC Health Serv. Res. 2017, 17, 550. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  27. Adibi, S. Introduction. In Mobile Health; Adibi, S., Ed.; Springer: Berlin, Germany, 2015; pp. 1–7. [Google Scholar]
  28. Kang, C.; Yang, S.; Yuan, J.; Xu, L.; Zhao, X.; Yang, J. Patients with chronic illness urgently need integrated physical and psychological care during the COVID-19 outbreak. Asian J. Psychiatr. 2020, 51, 102081. [Google Scholar] [CrossRef] [PubMed]
  29. Nomura, S.; Siesjo, V.; Tomson, G.; Mohr, W.; Fukuchi, E.; Shibuya, K.; Tangcharoensathien, V.; Hiroaki, M. Contributions of information and communications technology to future health systems and Universal Health Coverage: Application of Japan’s experiences. Health Res. Policy Syst. 2020, 18, 73. [Google Scholar] [CrossRef] [PubMed]
  30. Debon, R.; Coleone, J.D.; Bellei, E.A.; de Marchi, A.C.B. Mobile health applications for chronic diseases: A systematic review of features for lifestyle improvement. Diabetes Metab. Syndr. 2019, 13, 2507–2512. [Google Scholar] [CrossRef]
  31. Virella Perez, Y.I.; Medlow, S.; Ho, J.; Steinbeck, K. Mobile and web-based apps that support self-management and transition in young people with chronic illness: Systematic review. J. Med. Internet Res. 2019, 21, e13579. [Google Scholar] [CrossRef] [Green Version]
  32. Kirk, M.A.; Amiri, M.; Pirbaglou, M.; Ritvo, P. Wearable technology and physical activity behavior change in adults with chronic cardiometabolic disease: A systematic review and meta-analysis. Am. J. Health Promot. 2019, 33, 778–791. [Google Scholar] [CrossRef] [PubMed]
  33. Wieringa, F.P.; Broers, N.J.H.; Kooman, J.P.; van der Sande, F.M.; van Hoof, C. Wearable sensors: Can they benefit patients with chronic kidney disease? Expert Rev. Med. Devices 2017, 14, 505–519. [Google Scholar] [CrossRef] [PubMed]
  34. Liberati, A.; Altman, D.G.; Tetzlaff, J.; Mulrow, C.; Gotzsche, P.C.; Ioannidis, J.P.; Clarke, M.; Devereaux, P.J.; Kleijnen, J.; Moher, D. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration. PLoS Med. 2009, 6, e1000100. [Google Scholar] [CrossRef]
  35. Izudi, J.; Semakula, D.; Sennono, R.; Tamwesigire, I.K.; Bajunirwe, F. Protocol for systematic review and meta-analysis of treatment success rate among adult patients with tuberculosis in sub-Saharan Africa. BMJ Open 2018, 8, e024559. [Google Scholar] [CrossRef] [Green Version]
  36. Mayer, M.A.; Rodriguez Blanco, O.; Torrejon, A. Use of health apps by nurses for professional purposes: Web-based survey study. JMIR mHealth uHealth 2019, 7, e15195. [Google Scholar] [CrossRef] [Green Version]
  37. Keogh, J.W.L.; Cox, A.; Anderson, S.; Liew, B.; Olsen, A.; Schram, B.; Furness, J. Reliability and validity of clinically accessible smartphone applications to measure joint range of motion: A systematic review. PLoS ONE 2019, 14, e0215806. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  38. Testa, A.; Cinque, M.; Coronato, A.; de Pietro, G. A formal approach for a dependability assessment of a mHealth monitoring system. In Mobile Health; Adibi, S., Ed.; Springer: Berlin, Germany, 2015; pp. 171–194. [Google Scholar]
  39. Jandoo, T. WHO guidance for digital health: What it means for researchers. Digit. Health 2020, 6, 2055207619898984. [Google Scholar] [CrossRef] [PubMed]
  40. Kim, Y.; Groombridge, C.; Romero, L.; Clare, S.; Fitzgerald, M.C. Decision support capabilities of telemedicine in emergency prehospital care: Systematic review. J. Med. Internet Res. 2020, 22, e18959. [Google Scholar] [CrossRef] [PubMed]
  41. Sousa, P.S.; Sabugueiro, D.; Felizardo, V.; Couto, R.; Pires, I.; Garcia, N.M. mHealth sensors and applications for personal aid. In Mobile Health; Adibi, S., Ed.; Springer: Berlin, Germany, 2015; pp. 265–281. [Google Scholar]
  42. Kaur, A.; Kaur, K. Systematic literature review of mobile application development and testing effort estimation. J. King Saud Univ. Comput. Inf. Sci. 2018. [Google Scholar] [CrossRef]
  43. Waffenschmidt, S.; Knelangen, M.; Sieben, W.; Buhn, S.; Pieper, D. Single screening versus conventional double screening for study selection in systematic reviews: A methodological systematic review. BMC Med. Res. Methodol. 2019, 19, 132. [Google Scholar] [CrossRef]
  44. Jiang, J.; Cameron, A.-F. IT-enabled self-monitoring for chronic disease self-management: An interdisciplinary review. MIS Q. 2020, 44, 451–508. [Google Scholar] [CrossRef]
  45. Lewis, T.L.; Wyatt, J.C. mHealth and mobile medical apps: A framework to assess risk and promote safer use. J. Med. Internet Res. 2014, 16, e210. [Google Scholar] [CrossRef]
  46. Liu, L.; Stroulia, E.; Nikolaidis, I.; Miguel-Cruz, A.; Rios Rincon, A. Smart homes and home health monitoring technologies for older adults: A systematic review. Int. J. Med Inform. 2016, 91, 44–59. [Google Scholar] [CrossRef]
  47. Arcadius Tokognon, C.; Gao, B.; Tian, G.Y.; Yan, Y. Structural health monitoring framework based on Internet of Things: A survey. IEEE Internet Things J. 2017, 4, 619–635. [Google Scholar] [CrossRef]
  48. Sony, S.; Laventure, S.; Sadhu, A. A literature review of next-generation smart sensing technology in structural health monitoring. Struct. Control. Health Monit. 2019, 26, e2321. [Google Scholar] [CrossRef]
  49. Helweg-Jorgensen, S.; Beck Lichtenstein, M.; Fruzzetti, A.E.; Moller Dahl, C.; Pedersen, S.S. Daily self-monitoring of symptoms and skills learning in patients with borderline personality disorder through a mobile phone app: Protocol for a pragmatic randomized controlled trial. JMIR Res. Protoc. 2020, 9, e17737. [Google Scholar] [CrossRef] [PubMed]
  50. Rezvanizaniani, S.M.; Liu, Z.; Chen, Y.; Lee, J. Review and recent advances in battery health monitoring and prognostics technologies for electric vehicle (EV) safety and mobility. J. Power Sources 2014, 256, 110–124. [Google Scholar] [CrossRef]
  51. Khuc, T.; Catbas, F.N. Completely contactless structural health monitoring of real-life structures using cameras and computer vision. Struct. Control Health Monit. 2017, 24, e1852. [Google Scholar] [CrossRef]
  52. Liu, Z.; Kleiner, Y. State-of-the-art review of technologies for pipe structural health monitoring. IEEE Sens. J. 2012, 12, 1987–1992. [Google Scholar] [CrossRef]
  53. Faerber, A.E.; Horvath, R.; Stillman, C.; O’Connell, M.L.; Hamilton, A.L.; Newhall, K.A.; Likosky, D.S.; Goodney, P.P. Development and pilot feasibility study of a health information technology tool to calculate mortality risk for patients with asymptomatic carotid stenosis: The Carotid Risk Assessment Tool (CARAT). BMC Med. Inform. Decis. Mak. 2015, 15, 20. [Google Scholar] [CrossRef] [Green Version]
  54. Stoyanov, S.R.; Hides, L.; Kavanagh, D.J.; Zelenko, O.; Tjondronegoro, D.; Mani, M. Mobile app rating scale: A new tool for assessing the quality of health mobile apps. JMIR mHealth uHealth 2015, 3, e27. [Google Scholar] [CrossRef] [Green Version]
  55. Torous, J.; Friedman, R.; Keshavan, M. Smartphone ownership and interest in mobile applications to monitor symptoms of mental health conditions. JMIR mHealth uHealth 2014, 2, e2. [Google Scholar] [CrossRef]
  56. McGillicuddy, J.W.; Weiland, A.K.; Frenzel, R.M.; Mueller, M.; Brunner-Jackson, B.M.; Taber, D.J.; Baliga, P.K.; Treiber, F.A. Patient attitudes toward mobile phone-based health monitoring: Questionnaire study among kidney transplant recipients. J. Med. Internet Res. 2013, 15, e6. [Google Scholar] [CrossRef]
  57. Sun, A.C.; Yao, C.; Venkatesh, A.G.; Hall, D.A. An efficient power harvesting mobile phone-based electrochemical biosensor for point-of-care health monitoring. Sens. Actuators B Chem. 2016, 235, 126–135. [Google Scholar] [CrossRef] [Green Version]
  58. Lopez-Bastida, J.; Oliva, J.; Antonanzas, F.; Garcia-Altes, A.; Gisbert, R.; Mar, J.; Puig-Junoy, J. Spanish recommendations on economic evaluation of health technologies. Eur. J. Health Econ. 2010, 11, 513–520. [Google Scholar] [CrossRef]
  59. Claxton, K.; Paulden, M.; Gravelle, H.; Brouwer, W.; Culyer, A.J. Discounting and decision making in the economic evaluation of health-care technologies. Health Econ. 2011, 20, 2–15. [Google Scholar] [CrossRef] [PubMed]
  60. Davidson, T.M.; Bunnell, B.E.; Saunders, B.E.; Hanson, R.F.; Danielson, C.K.; Cook, D.; Chu, B.C.; Dorsey, S.; Adams, Z.W.; Andrews, A.R., III; et al. Pilot evaluation of a tablet-based application to improve quality of care in child mental health treatment. Behav. Ther. 2019, 50, 367–379. [Google Scholar] [CrossRef]
  61. Di Palma, S.; Tonacci, A.; Narzisi, A.; Domenici, C.; Pioggia, G.; Muratori, F.; Billeci, L.; The Michelangelo Study Group. Monitoring of autonomic response to sociocognitive tasks during treatment in children with autism spectrum disorders by wearable technologies: A feasibility study. Comput. Biol. Med. 2017, 85, 143–152. [Google Scholar] [CrossRef] [PubMed]
  62. Fadhlillah, R.; Susmartini, S.; Herdiman, L. Realtime health monitoring system design for children with cerebral palsy using internet of things. In Proceedings of the 2021 International Conference on Computer Engineering and Innovative Application of VR (ICCEIA VR 2021), Guangzhou, China, 11–13 June 2021; Volume 1961, p. 012119. [Google Scholar]
  63. Botros, A.; Schutz, N.; Camenzind, M.; Urwyler, P.; Bolliger, D.; Vanbellingen, T.; Kistler, R.; Bohlhalter, S.; Muri, R.M.; Mosimann, U.P.; et al. Long-term home-monitoring sensor technology in patients with parkinson’s disease—Acceptance and adherence. Sensors 2019, 19, 5169. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  64. Pavic, M.; Klaas, V.; Theile, G.; Kraft, J.; Troster, G.; Blum, D.; Guckenberger, M. Mobile health technologies for continuous monitoring of cancer patients in palliative care aiming to predict health status deterioration: A feasibility study. J. Palliat. Med. 2020, 23, 678–685. [Google Scholar] [CrossRef] [PubMed]
  65. Tregarthen, J.; Kim, J.P.; Sadeh-Sharvit, S.; Neri, E.; Welch, H.; Lock, J. Comparing a tailored self-help mobile app with a standard self-monitoring app for the treatment of eating disorder symptoms: Randomized controlled trial. JMIR Ment. Health 2019, 6, e14972. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  66. Siriwoen, R.; Chongsuwat, R.; Tansakul, S.; Siri, S. Effectiveness of a weight management program applying mobile health technology as a supporting tool for overweight and obese working women. Asia-Pac. J. Public Health 2018, 30, 572–581. [Google Scholar] [CrossRef]
  67. Lin, W.Y.; Ke, H.L.; Chou, W.C.; Chang, P.C.; Tsai, T.H.; Lee, M.Y. Realization and technology acceptance test of a wearable cardiac health monitoring and early warning system with multi-channel MCGs and ECG. Sensors 2018, 18, 3538. [Google Scholar] [CrossRef] [Green Version]
  68. Prada, P.; Zamberg, I.; Bouillault, G.; Jimenez, N.; Zimmermann, J.; Hasler, R.; Aubry, J.M.; Nicastro, R.; Perroud, N. EMOTEO: A smartphone application for monitoring and reducing aversive tension in borderline personality disorder patients, a pilot study. Perspect. Psychiatr. Care 2017, 53, 289–298. [Google Scholar] [CrossRef]
  69. Quinn, T.J.; Livingstone, I.; Weir, A.; Shaw, R.; Breckenridge, A.; McAlpine, C.; Tarbert, C.M. Accuracy and feasibility of an android-based digital assessment tool for post stroke visual disorders—The StrokeVision app. Front. Neurol. 2018, 9, 146. [Google Scholar] [CrossRef] [Green Version]
  70. Merrill, R.M. Practical disease concept in epidemiology. In Introduction to Epidemiology, 7th ed.; Jones and Bartlett Learning: Burlington, MA, USA, 2017; p. 41. [Google Scholar]
  71. Grunfeld, E.; Manca, D.; Moineddin, R.; Thorpe, K.E.; Hoch, J.S.; Campbell-Scherer, D.; Meaney, C.; Rogers, J.; Beca, J.; Krueger, P.; et al. Improving chronic disease prevention and screening in primary care: Results of the BETTER pragmatic cluster randomized controlled trial. BMC Fam. Pract. 2013, 14, 175. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  72. Cramm, J.M.; Nieboer, A.P. Is “disease management” the answer to our problems? No! Population health management and (disease) prevention require “management of overall well-being”. BMC Health Serv. Res. 2016, 16, 500. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  73. Christensen, J. Epidemiological concepts regarding disease monitoring and surveillance. Acta Vet. Scand. 2001, 42, 11–16. [Google Scholar] [CrossRef] [Green Version]
  74. Gerdes, M.; Trinugroho, Y.B.D.; Næss, M.; Fensli, R. Security, reliability and usability of mhealth environments. In Mobile Health; Adibi, S., Ed.; Springer: Berlin, Germany, 2015; pp. 1043–1066. [Google Scholar]
  75. Rothstein, M.A.; Wilbanks, J.T.; Beskow, L.M.; Brelsford, K.M.; Brothers, K.B.; Doerr, M.; Evans, B.J.; Hammack-Aviran, C.M.; McGowan, M.L.; Tovino, S.A. Unregulated health research using mobile devices: Ethical Considerations and policy recommendations. J. Law Med. Ethics 2020, 48, 196–226. [Google Scholar] [CrossRef] [PubMed]
  76. Jogova, M.; Shaw, J.; Jamieson, T. The regulatory challenge of mobile health: Lessons for Canada. Healthc. Policy 2019, 14, 19–28. [Google Scholar] [CrossRef] [PubMed]
  77. Shannon, G.; Jansen, M.; Williams, K.; Cáceres, C.; Motta, A.; Odhiambo, A.; Eleveld, A.; Mannell, J. Gender equality in science, medicine, and global health: Where are we at and why does it matter? Lancet 2019, 393, 560–569. [Google Scholar] [CrossRef] [Green Version]
  78. Gordon, W.J.; Landman, A.; Zhang, H.; Bates, D.W. Beyond validation: Getting health apps into clinical practice. NPJ Digit. Med. 2020, 3, 14. [Google Scholar] [CrossRef] [Green Version]
  79. Rodriguez-Villa, E.; Torous, J. Regulating digital health technologies with transparency: The case for dynamic and multi-stakeholder evaluation. BMC Med. 2019, 17, 226. [Google Scholar] [CrossRef] [Green Version]
  80. Van Velthoven, M.H.; Smith, J.; Wells, G.; Brindley, D. Digital health app development standards: A systematic review protocol. BMJ Open 2018, 8, e022969. [Google Scholar] [CrossRef] [Green Version]
  81. Wallace, J.; Kanegaonkar, R. The role of smartphone applications in clinical practice: A review. J. Laryngol. Otol. 2020, 134, 1–8. [Google Scholar] [CrossRef] [PubMed]
  82. World Health Organization. Cancer, 2018. Available online: https://www.who.int/health-topics/cancer (accessed on 6 November 2020).
  83. Heidari, A. Terahertz technology in the future of health and medical applications. In Mobile Health; Adibi, S., Ed.; Springer: Berlin, Germany, 2015; pp. 663–670. [Google Scholar]
  84. Tatari, C.R.; Andersen, B.; Brogaard, T.; Badre-Esfahani, S.K.; Jaafar, N.; Kirkegaard, P. Perceptions about cancer and barriers towards cancer screening among ethnic minority women in a deprived area in Denmark—A qualitative study. BMC Public Health 2020, 20, 921. [Google Scholar] [CrossRef]
  85. O’Hara, J.; McPhee, C.; Dodson, S.; Cooper, A.; Wildey, C.; Hawkins, M.; Fulton, A.; Pridmore, V.; Cuevas, V.; Scanlon, M.; et al. Barriers to breast cancer screening among diverse cultural groups in Melbourne, Australia. Int. J. Environ. Res. Public Health 2018, 15, 1677. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  86. Nagendiram, A.; Bougher, H.; Banks, J.; Hall, L.; Heal, C. Australian women’s self-perceived barriers to participation in cervical cancer screening: A systematic review. Health Promot. J. Austr. 2020, 31, 343–353. [Google Scholar] [CrossRef] [PubMed]
  87. Jones, D.; Neal, R.D.; Duffy, S.R.G.; Scott, S.E.; Whitaker, K.L.; Brain, K. Impact of the COVID-19 pandemic on the symptomatic diagnosis of cancer: The view from primary care. Lancet Oncol. 2020, 21, 748–750. [Google Scholar] [CrossRef]
  88. Biswas, S.; Adhikari, S.D.; Gupta, N.; Garg, R.; Bharti, S.J.; Kumar, V.; Mishra, S.; Bhatnagar, S. Smartphone-based telemedicine service at palliative care unit during nationwide lockdown: Our initial experience at a tertiary care cancer hospital. Indian J. Palliat. Care 2020, 26, S31. [Google Scholar] [PubMed]
  89. Adibi, S. Mobile health (mHealth) biomedical imaging paradigm. In Proceedings of the 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC’13), Osaka, Japan, 3–7 July 2013. [Google Scholar]
  90. Freeman, K.; Dinnes, J.; Chuchu, N.; Takwoingi, Y.; Bayliss, S.E.; Matin, R.N.; Jain, A.; Walter, F.M.; Williams, H.C.; Deeks, J.J. Algorithm based smartphone apps to assess risk of skin cancer in adults: Systematic review of diagnostic accuracy studies. BMJ 2020, 368, 127. [Google Scholar] [CrossRef] [Green Version]
  91. Zheng, C.; Chen, X.; Weng, L.; Guo, L.; Xu, H.; Lin, M.; Xue, Y.; Lin, X.; Yang, A.; Yu, L.; et al. Benefits of mobile apps for cancer pain management: Systematic review. JMIR mHealth uHealth 2020, 8, e17055. [Google Scholar] [CrossRef] [PubMed]
  92. Cruz, F.; Vilela, R.A.; Ferreira, E.B.; Melo, N.S.; Reis, P. Evidence on the use of mobile apps during the treatment of breast cancer: Systematic review. JMIR mHealth uHealth 2019, 7, e13245. [Google Scholar] [CrossRef] [Green Version]
  93. Richards, R.; Kinnersley, P.; Brain, K.; McCutchan, G.; Staffurth, J.; Wood, F. Use of mobile devices to help cancer patients meet their information needs in non-inpatient settings: Systematic review. JMIR mHealth uHealth 2018, 6, e10026. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  94. Charbonneau, D.H.; Hightower, S.; Katz, A.; Zhang, K.; Abrams, J.; Senft, N.; Beebe-Dimmer, J.L.; Heath, E.; Eaton, T.; Thompson, H.S. Smartphone apps for cancer: A content analysis of the digital health marketplace. Digit. Health 2020, 6, 2055207620905413. [Google Scholar] [CrossRef] [Green Version]
  95. Low, C.A. Harnessing consumer smartphone and wearable sensors for clinical cancer research. NPJ Digit. Med. 2020, 3, 140. [Google Scholar] [CrossRef] [PubMed]
  96. Rothan, H.A.; Byrareddy, S.N. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J. Autoimmun. 2020, 109, 102433. [Google Scholar] [CrossRef] [PubMed]
  97. Chudasama, Y.V.; Gillies, C.L.; Zaccardi, F.; Coles, B.; Davies, M.J.; Seidu, S.; Khunti, K. Impact of COVID-19 on routine care for chronic diseases: A global survey of views from healthcare professionals. Diabetes Metab. Syndr. 2020, 14, 965–967. [Google Scholar] [CrossRef]
  98. Zeigler, Z.; Forbes, B.; Lopez, B.; Pedersen, G.; Welty, J.; Deyo, A.; Kerekes, M. Self-quarantine and weight gain related risk factors during the COVID-19 pandemic. Obes. Res. Clin. Pract. 2020, 14, 210–216. [Google Scholar]
  99. BMJ Best Practice. Coronavirus Disease 2019 (COVID-19), 2020. Available online: https://bestpractice.bmj.com/topics/en-us/3000168 (accessed on 13 August 2020).
  100. Seshadri, D.R.; Davies, E.V.; Harlow, E.R.; Hsu, J.J.; Knighton, S.C.; Walker, T.A.; Voos, J.E.; Drummond, C.K. Wearable sensors for COVID-19: A call to action to harness our digital infrastructure for remote patient monitoring and virtual assessments. Front. Digit. Health 2020, 2, 8. [Google Scholar] [CrossRef]
  101. Clipper, B. The influence of the COVID-19 pandemic on technology: Adoption in health care. Nurse Lead. 2020, 18, 500–503. [Google Scholar] [CrossRef]
  102. Holmes, E.A.; O’Connor, R.C.; Perry, V.H.; Tracey, I.; Wessely, S.; Arseneault, L.; Ballard, C.; Cristensen, A.; Cohen Silver, R.; Everall, I.; et al. Multidisciplinary research priorities for the COVID-19 pandemic: A call for action for mental health science. Lancet Psychiatry 2020, 7, 547–560. [Google Scholar] [CrossRef]
  103. Puntillo, F.; Giglio, M.; Brienza, N.; Viswanath, O.; Urits, I.; Kaye, A.D.; Pergolizzi, J.; Paladini, A.; Varrassi, G. Impact of COVID-19 pandemic on chronic pain management: Looking for the best way to deliver care. Best Pract. Res. Clin. Anaesthesiol. 2020, 34, 529–537. [Google Scholar] [CrossRef]
  104. Byambasuren, O.; Beller, E.; Glasziou, P. Current knowledge and adoption of mobile health apps among Australian general practitioners: Survey study. JMIR mHealth uHealth 2019, 7, e13199. [Google Scholar] [CrossRef] [Green Version]
  105. Dash, S.; Shakyawar, S.K.; Sharma, M.; Kaushik, S. Big data in healthcare: Management, analysis and future prospects. J. Big Data 2019, 6, 1–25. [Google Scholar] [CrossRef] [Green Version]
  106. Pastorino, R.; de Vito, C.; Migliara, G.; Glocker, K.; Binenbaum, I.; Ricciardi, W.; Boccia, S. Benefits and challenges of Big Data in healthcare: An overview of the European initiatives. Eur. J. Public Health 2019, 29, 23–27. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  107. Madanian, S.; Parry, D.T.; Airehrour, D.; Cherrington, M. mHealth and big-data integration: Promises for healthcare system in India. BMJ Health Care Inform. 2019, 26, e100071. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  108. Sako, Z.; Adibi, S.; Wickramasinghe, N. Addressing data accuracy and information integrity in mHealth solutions using machine learning algorithms. In Delivering Superior Health and Wellness Management with IoT and Analytics; Wickramasinghe, N., Bodendorf, F., Eds.; Springer: Berlin, Germany, 2019; pp. 345–359. [Google Scholar]
  109. Holman, N.; Knighton, P.; Kar, P.; O’Keefe, J.; Curley, M.; Weaver, A.; Barron, E.; Bakhai, C.; Khunti, K.; Wareham, N.; et al. Risk factors for COVID-19-related mortality in people with type 1 and type 2 diabetes in England: A population-based cohort study. Lancet Diabetes Endocrinol. 2020, 8, 823–833. [Google Scholar] [CrossRef]
  110. Gregory, J.M.; Slaughter, J.C.; Duffus, S.H.; Smith, T.J.; LeStourgeon, L.M.; Jaser, S.S.; McCoy, A.B.; Luther, J.M.; Giovannetti, E.R.; Boeder, S.; et al. COVID-19 severity is tripled in the diabetes community: A prospective analysis of the pandemic’s impact in type 1 and type 2 diabetes. Diabetes Care 2021, 44, 526–532. [Google Scholar] [CrossRef]
  111. Ventola, C.L. Mobile devices and apps for health care professionals: Uses and benefits. Pharm. Ther. 2014, 39, 9. [Google Scholar]
Figure 1. Flow diagram for selection of articles; (adapted from reference [34]).
Figure 1. Flow diagram for selection of articles; (adapted from reference [34]).
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Figure 2. App functionalities and classification.
Figure 2. App functionalities and classification.
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Table 1. Selection criteria for review articles (adapted from reference [44]).
Table 1. Selection criteria for review articles (adapted from reference [44]).
Inclusion Criteria:
  • Data collected through electronic tools: e.g., smartphone applications and wearable sensors.
  • Human subjects living with chronic disease. Participants aged ≥18 years.
  • Number of participants ≥15.
  • Year of publication: January 2010–July 2020.
  • Examine the use of technology and disease monitoring and management.
Exclusion Criteria:
  • Publications on incomplete or part of research (e.g., editorials, abstracts, workshop/conference summaries, research proposals, descriptive survey, clinical protocols, research methods, literature reviews, conceptual papers).
  • Participants aged <18 years.
  • Non-human focused (e.g., building, physical structures, bridges, health economic, evaluation of study ethics).
  • Use of non-electronic tools to collect data (e.g., paper-based questionnaire, opinions, viewpoints).
  • Evaluation and development of research tools (e.g., hardware and algorithm improvement studies, and clinical measurement technology to access and analyse secondary data).
Table 2. Characteristics of included studies.
Table 2. Characteristics of included studies.
ArticlesStudy TypeCountryCountAgeMale (%)Female (%)AppWearableQuestionnaireClinical EvaluationDuration (Weeks)
(Pavic, 2020) [64]Obs.Swiss30647129Active monitoringBraceletYes-12
(Tregarthen, 2019) [65]Exp.US959µ:34694Recovery record-Yes-8
(Siriwoen, 2018) [66]Exp.Thailand3825–52-100LINE, Health app, Accupedo Pedometer.-YesYes12
(Lin, 2018) [67]Exp.Taiwan4820–90+7723CHAMPSmart vestYesYesFew hours in clinic.
(Prada, 2017) [68]Obs.Swiss1618–50-100EMOTEO---24
Obs: Observation, Exp: Experimental, App: Smartphone application, Swiss: Switzerland, US: United Nations.
Table 3. Risk assessment of selected studies.
Table 3. Risk assessment of selected studies.
Articles(Pavic, 2020) [64](Tregarthen, 2019) [65](Siriwoen, 2018) [66](Lin, 2018) [67](Prada, 2017) [68]
Inherent to the app.Intended functionHigh-riskLow riskLow riskHigh-riskHigh-risk
Inaccurate or out of date contentNot specified
Complexity of task supported by the appHigh-riskLow riskLow riskHigh-riskHigh-risk
Lack of feedback or failsafe mechanismNot specified
External factors, depending on context of app use.App userYesYesYesYesYes
Inappropriate app usageNoNoNoNoNo
Inadequate user trainingLow riskHigh-riskLow riskLow riskHigh-risk
Likelihood of errors being detectedHigh-riskLow riskLow riskLow riskLow risk
App usage factor (AUF)LowHighLowLowLow
Table 4. Technology acceptance evaluation.
Table 4. Technology acceptance evaluation.
ArticlePatient Medical ConditionTechnology Acceptance Evaluation MethodologyResponseComments
(Pavic, 2020) [64]Terminal cancer.Customised questionnaire
  • 76% appreciated the monitoring.
  • 93% felt the wearable comfy.
  • Bracelet-worn on 53% study days.
  • Smartphone used on 85% study days.
Remote monitoring of palliative cancer patients using app integrated wearables is feasible.
(Tregarthen, 2019) [65]Eating disorder.Not Specified
(Siriwoen, 2018) [66]BMI ≥25.
(Lin, 2018) [67]Heart failure.Technology Acceptance Model
  • Positive response in 8/10 criteria.
Remote cardiac monitoring using wearables is feasible.
(Prada, 2017) [68]Borderline personality disorder.Duration of app usage
  • (11.95 ± 9.75) sessions per week.
  • (1.21 ± 1.12) recordings per day.
  • (318.1 ± 166.7 min) per subject overall time exposed to the app.
Decrease in aversion tension. Higher app usage statistics is proportion to the effectiveness of the app.
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Moses, J.C.; Adibi, S.; Shariful Islam, S.M.; Wickramasinghe, N.; Nguyen, L. Application of Smartphone Technologies in Disease Monitoring: A Systematic Review. Healthcare 2021, 9, 889. https://doi.org/10.3390/healthcare9070889

AMA Style

Moses JC, Adibi S, Shariful Islam SM, Wickramasinghe N, Nguyen L. Application of Smartphone Technologies in Disease Monitoring: A Systematic Review. Healthcare. 2021; 9(7):889. https://doi.org/10.3390/healthcare9070889

Chicago/Turabian Style

Moses, Jeban Chandir, Sasan Adibi, Sheikh Mohammed Shariful Islam, Nilmini Wickramasinghe, and Lemai Nguyen. 2021. "Application of Smartphone Technologies in Disease Monitoring: A Systematic Review" Healthcare 9, no. 7: 889. https://doi.org/10.3390/healthcare9070889

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