Glucocorticoid/Adiponectin Axis Mediates Full Activation of Cold-Induced Beige Fat Thermogenesis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Mice
2.3. Hydrocortisone or Mifepristone Administrations
2.4. Calorimetry Study
2.5. Cell Culture and Treatment
2.6. Western Blot
2.7. Statistics
3. Results
3.1. Circulating Levels of Corticosterone Are Elevated by Acute Cold Stress
3.2. Hydrocortisone Administration Enhanced Oxygen Consumption and Thermogenic Gene Expression
3.3. Blocking Glucocorticoid Receptor Signaling Leads to Decreased Energy Expenditure and Thermogenesis in an Adiponectin-Dependent Manner
3.4. Hydrocortisone Suppressed Adiponectin Transcription via GR-Dependent Mechanism in Adipocytes
3.5. Glucocorticoid Suppresses Adiponectin Expression by Regulating PPARγ Activity
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Acknowledgments
Conflicts of Interest
References
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Luo, L.; Wang, L.; Luo, Y.; Romero, E.; Yang, X.; Liu, M. Glucocorticoid/Adiponectin Axis Mediates Full Activation of Cold-Induced Beige Fat Thermogenesis. Biomolecules 2021, 11, 1573. https://doi.org/10.3390/biom11111573
Luo L, Wang L, Luo Y, Romero E, Yang X, Liu M. Glucocorticoid/Adiponectin Axis Mediates Full Activation of Cold-Induced Beige Fat Thermogenesis. Biomolecules. 2021; 11(11):1573. https://doi.org/10.3390/biom11111573
Chicago/Turabian StyleLuo, Liping, Lu Wang, Yan Luo, Estevan Romero, Xin Yang, and Meilian Liu. 2021. "Glucocorticoid/Adiponectin Axis Mediates Full Activation of Cold-Induced Beige Fat Thermogenesis" Biomolecules 11, no. 11: 1573. https://doi.org/10.3390/biom11111573