Next Article in Journal
Studies on the Reactivity of (9-Methyl-5,6-dihydronaphtho[1',2':4,5]- thieno[2,3-d]pyrimidin-11-yl)hydrazine Towards Some Reagents for Biological Evaluation
Previous Article in Journal
Phytoestrogen Biological Actions on Mammalian Reproductive System and Cancer Growth
 
 
Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

New Substituted Isocoumarins and Dihydroisocoumarins and their Cytotoxic Activities

Department of Pharmacy – Center for Drug Research, Ludwig-Maximilians University, Butenandtstr. 5–13, D-81377 Munich, Germany
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2011, 79(1), 21-30; https://doi.org/10.3797/scipharm.1011-10
Submission received: 30 November 2010 / Accepted: 17 December 2010 / Published: 18 December 2010

Abstract

New isocoumarins were prepared in an efficient way from 2-iodobenzoic acid derivatives and hept-1-yne in a Sonogashira reaction, followed by spontaneous cyclization. Catalytic hydrogenation gave the corresponding dihydroisocoumarins. A 4-chloroisocoumarin was prepared on an alternative pathway. Some of the new compounds showed moderate cytotoxic activities against a human leukemia cell line (HL 60).
Keywords: Isocoumarins; Dihydroisocoumarins; Sonogashira reaction; Cyclization; Cytotoxicity Isocoumarins; Dihydroisocoumarins; Sonogashira reaction; Cyclization; Cytotoxicity

Share and Cite

MDPI and ACS Style

Hampl, V.; Wetzel, I.; Bracher, F.; KRAUSS, J. New Substituted Isocoumarins and Dihydroisocoumarins and their Cytotoxic Activities. Sci. Pharm. 2011, 79, 21-30. https://doi.org/10.3797/scipharm.1011-10

AMA Style

Hampl V, Wetzel I, Bracher F, KRAUSS J. New Substituted Isocoumarins and Dihydroisocoumarins and their Cytotoxic Activities. Scientia Pharmaceutica. 2011; 79(1):21-30. https://doi.org/10.3797/scipharm.1011-10

Chicago/Turabian Style

Hampl, Veronika, Isolde Wetzel, Franz Bracher, and Jürgen KRAUSS. 2011. "New Substituted Isocoumarins and Dihydroisocoumarins and their Cytotoxic Activities" Scientia Pharmaceutica 79, no. 1: 21-30. https://doi.org/10.3797/scipharm.1011-10

Article Metrics

Back to TopTop