Next Issue
Volume 2, June
Previous Issue
Volume 1, December
 
 

J. Pers. Med., Volume 2, Issue 1 (March 2012) – 2 articles , Pages 1-34

  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list.
  • You may sign up for e-mail alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.
Order results
Result details
Section
Select all
Export citation of selected articles as:
323 KiB  
Opinion
Trends in Personalized Therapies in Oncology: The (Venture) Capitalist’s Perspective
by Roman Fleck and Daniel Bach
J. Pers. Med. 2012, 2(1), 15-34; https://doi.org/10.3390/jpm2010015 - 07 Mar 2012
Cited by 8 | Viewed by 7490
Abstract
Oncology is one of the most important fields of personalized medicine as a majority of efforts in this field have recently centered on targeted cancer drug development. New tools are continuously being developed that promise to make cancer treatment more efficacious while causing [...] Read more.
Oncology is one of the most important fields of personalized medicine as a majority of efforts in this field have recently centered on targeted cancer drug development. New tools are continuously being developed that promise to make cancer treatment more efficacious while causing fewer side effects. Like most industries, the biopharmaceutical industry is also following certain global trends and these are analyzed in this article. As academia and industry are mutually dependent on each other, researchers in the field should be aware of those trends and the immediate consequences for their research. It is important for the future of this field that there is a healthy relationship among all interested parties as the challenges of personalized medicine are becoming ever more complex. Full article
(This article belongs to the Special Issue Recent Advances in Personalized Medicine)
Show Figures

Figure 1

181 KiB  
Review
Personalized Medicine and Cancer
by Mukesh Verma
J. Pers. Med. 2012, 2(1), 1-14; https://doi.org/10.3390/jpm2010001 - 30 Jan 2012
Cited by 131 | Viewed by 17300
Abstract
Cancer is one of the leading causes of death in the United States, and more than 1.5 million new cases and more than 0.5 million deaths were reported during 2010 in the United States alone. Following completion of the sequencing of the human [...] Read more.
Cancer is one of the leading causes of death in the United States, and more than 1.5 million new cases and more than 0.5 million deaths were reported during 2010 in the United States alone. Following completion of the sequencing of the human genome, substantial progress has been made in characterizing the human epigenome, proteome, and metabolome; a better understanding of pharmacogenomics has been developed, and the potential for customizing health care for the individual has grown tremendously. Recently, personalized medicine has mainly involved the systematic use of genetic or other information about an individual patient to select or optimize that patient’s preventative and therapeutic care. Molecular profiling in healthy and cancer patient samples may allow for a greater degree of personalized medicine than is currently available. Information about a patient’s proteinaceous, genetic, and metabolic profile could be used to tailor medical care to that individual’s needs. A key attribute of this medical model is the development of companion diagnostics, whereby molecular assays that measure levels of proteins, genes, or specific mutations are used to provide a specific therapy for an individual’s condition by stratifying disease status, selecting the proper medication, and tailoring dosages to that patient’s specific needs. Additionally, such methods can be used to assess a patient’s risk factors for a number of conditions and to tailor individual preventative treatments. Recent advances, challenges, and future perspectives of personalized medicine in cancer are discussed. Full article
(This article belongs to the Special Issue Recent Advances in Personalized Medicine)
Previous Issue
Next Issue
Back to TopTop