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The Nutraceutical N-Palmitoylethanolamide (PEA) Reveals Widespread Molecular Effects Unmasking New Therapeutic Targets in Murine Varicocele
 
 
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Nutrients
Volume 15
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10.3390/nu15071662
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Correction to Nutrients 2021, 13(3), 734.
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Correction

Correction: Antonuccio et al. The Nutraceutical N-Palmitoylethanolamide (PEA) Reveals Widespread Molecular Effects Unmasking New Therapeutic Targets in Murine Varicocele. Nutrients 2021, 13, 734

by
Pietro Antonuccio
1,†,
Herbert Ryan Marini
2,†,
Antonio Micali
3,
Carmelo Romeo
1,
Roberta Granese
1,
Annalisa Retto
1,
Antonia Martino
1,
Salvatore Benvenga
2,
Salvatore Cuzzocrea
4,
Daniela Impellizzeri
4,
Rosanna Di Paola
4,*,
Roberta Fusco
4,
Raimondo Maximilian Cervellione
5 and
Letteria Minutoli
2
1
Department of Human Pathology of Adult and Childhood, University of Messina, 98125 Messina, Italy
2
Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy
3
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98125 Messina, Italy
4
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy
5
Department of Paediatric Urology, Royal Manchester Children’s Hospital, Oxford Road, Manchester M13 9WL, UK
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Nutrients 2023, 15(7), 1662; https://doi.org/10.3390/nu15071662
Submission received: 30 December 2022 / Revised: 16 March 2023 / Accepted: 20 March 2023 / Published: 29 March 2023
(This article belongs to the Special Issue Non- and Low-Polar Phytonutrients—Preventive Potential)
Browse Figures
Versions Notes

Error in Figure

In the original publication [1], there was a mistake in Figures 2 and 3 as published. The authors presented a factual error in the figures, copying and pasting the same information twice in two different places. In the original version, Figures 2I and 3D displayed an identical histological image. In the correction, both have been replaced. The corrected Figure 2 and Figure 3 appear below. The authors apologize for any inconvenience caused and state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.

Reference

  1. Antonuccio, P.; Marini, H.R.; Micali, A.; Romeo, C.; Granese, R.; Retto, A.; Martino, A.; Benvenga, S.; Cuzzocrea, S.; Impellizzeri, D.; et al. The Nutraceutical N-Palmitoylethanolamide (PEA) Reveals Widespread Molecular Effects Unmasking New Therapeutic Targets in Murine Varicocele. Nutrients 2021, 13, 734. [Google Scholar] [CrossRef] [PubMed]
Nutrients 15 01662 g002 550
Figure 2. Effects of the absence of PPAR-α and TLR4 on PPAR-α expression. Immunohistochemical evaluation of PPAR-α expression. (A): Sham operated WT; (B): Sham operated PPAR-α KO; (C): Sham operated TLR4 KO; (D): Vehicle varicocele WT; (E): Vehicle varicocele PPAR-α KO; (F): Vehicle varicocele TLR4 KO; (G): PEA-um varicocele WT; (H): PEA-um varicocele PPAR-α KO; (I): PEA-um varicocele TLR4 KO; (J): Densitometric analysis; (K): Western blot analysis of PPAR-α expression; (L): densitometric analysis. Scale bar 100×. *** p < 0.001 vs. sham WT, ### p < 0.001 vs. vehicle WT; °°° p < 0.001 vs. sham TLR4, §§§ p < 0.001 vs. vehicle TLR4.
Figure 2. Effects of the absence of PPAR-α and TLR4 on PPAR-α expression. Immunohistochemical evaluation of PPAR-α expression. (A): Sham operated WT; (B): Sham operated PPAR-α KO; (C): Sham operated TLR4 KO; (D): Vehicle varicocele WT; (E): Vehicle varicocele PPAR-α KO; (F): Vehicle varicocele TLR4 KO; (G): PEA-um varicocele WT; (H): PEA-um varicocele PPAR-α KO; (I): PEA-um varicocele TLR4 KO; (J): Densitometric analysis; (K): Western blot analysis of PPAR-α expression; (L): densitometric analysis. Scale bar 100×. *** p < 0.001 vs. sham WT, ### p < 0.001 vs. vehicle WT; °°° p < 0.001 vs. sham TLR4, §§§ p < 0.001 vs. vehicle TLR4.
Nutrients 15 01662 g002
Nutrients 15 01662 g003 550
Figure 3. Effects of the absence of PPAR-α and TLR4 on TLR4 expression. Immunohistochemical evaluation of TLR4 expression. (A): Sham operated WT; (B): Sham operated PPAR-α KO; (C): Sham operated TLR4 KO; (D): Vehicle varicocele WT; (E): Vehicle varicocele PPAR-α KO; (F): Vehicle varicocele TLR4 KO; (G): PEA-um varicocele WT; (H): PEA-um varicocele PPAR-α KO; (I): PEA-um varicocele TLR4 KO; (J): Densitometric analysis; (K): Western blot analysis of TLR4 expression; (L): densitometric analysis. Scale bar 100×. *** p < 0.001 vs. sham WT, ### p < 0.001 vs. vehicle WT ˆˆˆ p < 0.001 vs. sham PPAR-α.
Figure 3. Effects of the absence of PPAR-α and TLR4 on TLR4 expression. Immunohistochemical evaluation of TLR4 expression. (A): Sham operated WT; (B): Sham operated PPAR-α KO; (C): Sham operated TLR4 KO; (D): Vehicle varicocele WT; (E): Vehicle varicocele PPAR-α KO; (F): Vehicle varicocele TLR4 KO; (G): PEA-um varicocele WT; (H): PEA-um varicocele PPAR-α KO; (I): PEA-um varicocele TLR4 KO; (J): Densitometric analysis; (K): Western blot analysis of TLR4 expression; (L): densitometric analysis. Scale bar 100×. *** p < 0.001 vs. sham WT, ### p < 0.001 vs. vehicle WT ˆˆˆ p < 0.001 vs. sham PPAR-α.
Nutrients 15 01662 g003
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MDPI and ACS Style

Antonuccio, P.; Marini, H.R.; Micali, A.; Romeo, C.; Granese, R.; Retto, A.; Martino, A.; Benvenga, S.; Cuzzocrea, S.; Impellizzeri, D.; et al. Correction: Antonuccio et al. The Nutraceutical N-Palmitoylethanolamide (PEA) Reveals Widespread Molecular Effects Unmasking New Therapeutic Targets in Murine Varicocele. Nutrients 2021, 13, 734. Nutrients 2023, 15, 1662. https://doi.org/10.3390/nu15071662

AMA Style

Antonuccio P, Marini HR, Micali A, Romeo C, Granese R, Retto A, Martino A, Benvenga S, Cuzzocrea S, Impellizzeri D, et al. Correction: Antonuccio et al. The Nutraceutical N-Palmitoylethanolamide (PEA) Reveals Widespread Molecular Effects Unmasking New Therapeutic Targets in Murine Varicocele. Nutrients 2021, 13, 734. Nutrients. 2023; 15(7):1662. https://doi.org/10.3390/nu15071662

Chicago/Turabian Style

Antonuccio, Pietro, Herbert Ryan Marini, Antonio Micali, Carmelo Romeo, Roberta Granese, Annalisa Retto, Antonia Martino, Salvatore Benvenga, Salvatore Cuzzocrea, Daniela Impellizzeri, and et al. 2023. "Correction: Antonuccio et al. The Nutraceutical N-Palmitoylethanolamide (PEA) Reveals Widespread Molecular Effects Unmasking New Therapeutic Targets in Murine Varicocele. Nutrients 2021, 13, 734" Nutrients 15, no. 7: 1662. https://doi.org/10.3390/nu15071662

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