Hematology Reports

1 pages, 252 KiB

Open AccessCorrection

Erratum: Managing Acute Promyelocytic Leukemia in Patients Belonging to the Jehovah’s Witness Congregation

by Anand P. Jillella, Martha L. Arellano, Leonard T. Heffner, Manila Gaddh, Amelia A. Langston, Hanna J. Khoury, Abhishek Mangaonkar and

Vamsi K. Kota

Hematol. Rep. 2019, 11(4), 8395; https://doi.org/10.4081/hr.2019.8395 - 04 Dec 2019

Viewed by 193

Abstract

Due to an error [...] Full article

3 pages, 331 KiB

Open AccessArticle

Splenomegaly Impacts Prognosis in Essential Thrombocythemia and Polycythemia Vera: A Single Center Study

Vincenzo Accurso

, Marco Santoro, Simona Raso, Angelo Davide Contrino, Paolo Casimiro, Florinda Di Piazza, Alessandro Perez, Antonio Russo and Sergio Siragusa

Hematol. Rep. 2019, 11(4), 8281; https://doi.org/10.4081/hr.2019.8281 - 04 Dec 2019

Cited by 16 | Viewed by 379

Abstract

Splenomegaly is one of the major clinical manifestations of primary myelofibrosis and is common also in other chronic Philadelphia-negative myeloproliferative neoplasms, causing symptoms and signs and affecting quality of life of patients diagnosed with these diseases. We aimed to study the impact that such alteration has on thrombotic risk and on the survival of patients with essential thrombocythemia and patients with Polycythemia Vera (PV). We studied the relationship between splenomegaly (and its grade), thrombosis and survival in 238 patients with et and 165 patients with PV followed at our center between January 1997 and May 2019. Full article

4 pages, 728 KiB

Open AccessCase Report

Miguel Lemos Gomes

, Alice Lopes, Ana Parente Freixo, Gonçalo Sobrinho, Ruy Fernandes and Luís Mendes Pedro

Hematol. Rep. 2019, 11(4), 8189; https://doi.org/10.4081/hr.2019.8189 - 04 Dec 2019

Cited by 1 | Viewed by 296

Abstract

Aortic abdominal aneurysm (AAA) is an uncommon etiology of disseminated intravascular coagulation (DIC). The authors report a case of an 81-year-old male patient who presented with hematuria, intraoral hemorrhage, melaenas and ecchymosis of the lower back and of the abdominal wall, after being medicated with etoricoxib for a back pain. During the study, an abdominal aortic aneurysm, which prolonged to the left common and internal iliac artery, was discovered. The diagnosis of AAA induced DIC was made. After endovascular aneurysm repair (EVAR), the patient’s hemorrhagic manifestations disappeared and the laboratory findings normalized. In conclusion, the state-of-the-art treatment of DIC is the elimination of the underlying disease; in this case, EVAR was proven to be effective in treating the aortic aneurysm and the AAA-related DIC. Full article

5 pages, 510 KiB

Open AccessArticle

Different Types of Amyloid Concomitantly Present in the Same Patients

and

Hematol. Rep. 2019, 11(4), 7996; https://doi.org/10.4081/hr.2019.7996 - 04 Dec 2019

Cited by 3 | Viewed by 344

Abstract

Different types of amyloid concomitantly present in the same patient is believed to be improbable. We reported four cases of patients with plasma cell disorders who were found to have biopsy proven concomitant different types of amyloid fibrils deposition. We characterized amyloid fibrils using immunogold electron microscopy. There is lack of experience in the treatment of these frail and elderly patients, who are on the threshold between necessity of chemotherapy for AL amyloidosis and necessity to avoid harmful treatment related toxicity. All patients with a systemic amyloid syndrome require therapy to prevent deposition of amyloid in other organs and prevent progressive organ failure. Stem cell transplant (SCT) is preferred, but only 20% of patients are eligible Requirements for safe SCT include systolic blood pressure > 90 mm Hg, troponin T < 0.06 ng/mL, age < 70 years, and serum creatinine ≤ 1.7 mg/dL Nontransplant candidates can be offered melphalandexamethasone or cyclophosphamide-bortezomibdexamethasone. Full article

5 pages, 374 KiB

Open AccessArticle

Clinicopathological Study and Outcomes of Primary Extranodal Lymphoma

Nichapa Nanthakwang

Ekarat Rattarittamrong

Thanawat Rattanathammethee

Chatree Chai-Adisaksopha

Adisak Tantiworawit

Lalita Norasetthada

and

Charin Ya-In

Hematol. Rep. 2019, 11(4), 8227; https://doi.org/10.4081/hr.2019.8227 - 29 Nov 2019

Cited by 5 | Viewed by 266

Abstract

Lymphoma can present with either lymphadenopathy or extranodal involvement. There are limited clinicopathological data pertaining to the occurrence of primary extranodal lymphoma (pENL) in Thailand. This was a retrospective study conducted at Chiang-Mai University Hospital from 2012 to 2016. Patients 18 years of age and over and with a diagnosis of pENL were enrolled onto study. Data related to clinical presentations, histology, stage, treatment and response were collected. There were 104 pENL patients with a median age of 63 years included. The most common presentation was gastrointestinal symptoms (41%), followed by ear, nose, and throat symptoms (35%). Diffuse large B-cell lymphoma (DLBCL) was the most common morphological subtype (60%), followed by marginal zone lymphoma (15%). The majority of patients presented with stage II disease (55%). The five-year overall survival rate was 71%. The factors associated with mortality were hemoglobin <7 g/dL, B-symptoms and LDH above upper normal limits. This study illustrated that lymphoma can present at various extranodal sites. Gastrointestinal symptoms were the most common presentations and DLBCL was the most common subtype of pENL. Full article

2 pages, 359 KiB

Open AccessCase Report

Localized Lymphadenopathy with Myelodysplastic Syndrome Associated with Tuberculosis

and

Hematol. Rep. 2019, 11(4), 8147; https://doi.org/10.4081/hr.2019.8147 - 29 Nov 2019

Cited by 1 | Viewed by 265

Abstract

We report the case of a man who developed myelodysplastic syndrome (MDS) and refractory cytopenia of unilineage dysplasia, 5 months after aortic valve replacement surgery. He also developed fever of unknown origin. After bone marrow- and other laboratory examinations, he was diagnosed with [...] Read more.

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Hematol. Rep., Volume 11, Issue 4 (November 2019) – 6 articles

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