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Article

Refractory Ulcerative Colitis Complicated by Cytomegalovirus Infection Successfully Treated With Valganciclovir

by
Tiziana Larussa
1,
Evelina Suraci
1,
Immacolata Nazionale
1,
Francesco Conforti
2,
Maria Imeneo
1 and
Francesco Luzza
1,*
1
Department of Health Science, University of Catanzaro Magna Graecia, Catanzaro, Italy
2
Department of Pathological Anatomy, University of Catanzaro Magna Graecia, Catanzaro, Italy
*
Author to whom correspondence should be addressed.
Gastroenterol. Insights 2012, 4(2), e19; https://doi.org/10.4081/gi.2012.e19
Submission received: 3 August 2011 / Revised: 12 June 2012 / Accepted: 12 July 2012 / Published: 13 November 2012

Abstract

Cytomegalovirus (CMV) infection is widespread in the general population. In patients with severe and/or steroid-refractory ulcerative colitis (UC), local reactivation of CMV can be detected in actively inflamed colonic tissue in approximately 30% of cases. However, the role of CMV in patients with UC is not clearly understood. There is evidence to show a possible role in exacerbating a colitis flare, whereas other studies describe CMV as an innocent bystander. We report the case of a patient with severe UC complicated by CMV infection who did not respond to conventional therapy. A complete diagnostic panel for CMV diagnosis, including tissue polymerase chain reaction and immunohistochemistry, was carried out. Three-week therapy with oral valganciclovir resulted in dramatic clinical and endoscopic improvement. Timing of diagnosis and treatment of CMV infection complicating UC is crucial in order to recognize the organ-disease and plan appropriate treatment.
Keywords: ulcerative colitis; cytomegalovirus; valganciclovir; ganciclovir ulcerative colitis; cytomegalovirus; valganciclovir; ganciclovir

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MDPI and ACS Style

Larussa, T.; Suraci, E.; Nazionale, I.; Conforti, F.; Imeneo, M.; Luzza, F. Refractory Ulcerative Colitis Complicated by Cytomegalovirus Infection Successfully Treated With Valganciclovir. Gastroenterol. Insights 2012, 4, e19. https://doi.org/10.4081/gi.2012.e19

AMA Style

Larussa T, Suraci E, Nazionale I, Conforti F, Imeneo M, Luzza F. Refractory Ulcerative Colitis Complicated by Cytomegalovirus Infection Successfully Treated With Valganciclovir. Gastroenterology Insights. 2012; 4(2):e19. https://doi.org/10.4081/gi.2012.e19

Chicago/Turabian Style

Larussa, Tiziana, Evelina Suraci, Immacolata Nazionale, Francesco Conforti, Maria Imeneo, and Francesco Luzza. 2012. "Refractory Ulcerative Colitis Complicated by Cytomegalovirus Infection Successfully Treated With Valganciclovir" Gastroenterology Insights 4, no. 2: e19. https://doi.org/10.4081/gi.2012.e19

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