Next Article in Journal
Mucosal Bridge due to Reflux Esophagitis
Previous Article in Journal
Correlation between the Preoperative State of Nutrition and the Frequency of Postoperative Problems after Video-Assisted Gastrostomy in Children
Gastroenterology Insights is published by MDPI from Volume 11 Issue 1 (2020). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on as a courtesy and upon agreement with PAGEPress.
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:

The Emerging Role of the Microbial-Gastrointestinal-Neural Axis

Peter G. McLean
Andrew R. Calver
David H. Alpers
Stephen M. Collins
Fergus Shanahan
5 and
Kevin Lee
Digestive Health, Nutrition & Health Department, Nestlé Research Centre, Lausanne, Switzerland
ImmunoInflammation Centre of Excellence in Drug Discovery, GlaxoSmithKline Ltd, Medicine Research Centre, Stevenage, Hertfordshire, UK
Division of Gastroenterology, Washington University School of Medicine, St Louis, Missouri, USA
Intestinal Diseases Research Programme, Health Science Centre, McMaster University, Hamilton, Ontario, Canada
Alimentary Pharmabiotic Centre, and Department of Medicine, University College Cork, National University of Ireland, Cork, Ireland
Author to whom correspondence should be addressed.
Gastroenterol. Insights 2009, 1(1), e3;
Submission received: 27 July 2009 / Accepted: 10 September 2009 / Published: 13 October 2009


The gastrointestinal tract and its associated mucosal immune system have been extensively studied in the context of their involvement in disease processes, both within the tract itself and in its associated organs. However, historically a number of aspects of both gastrointestinal physiology and pathophysiology have been to some extent overlooked. In particular, the relationship of the gastrointestinal tract with its indigenous microbiota, and also the influence of the tract on behavior and neural systems and vice versa. Here, we describe recent advances in our knowledge and understanding of these areas, and attempt to put these advances in perspective with regard to potential therapeutic strategies.
Keywords: gut microbiota; gut-brain axis; gastrointestinal disease gut microbiota; gut-brain axis; gastrointestinal disease

Share and Cite

MDPI and ACS Style

McLean, P.G.; Calver, A.R.; Alpers, D.H.; Collins, S.M.; Shanahan, F.; Lee, K. The Emerging Role of the Microbial-Gastrointestinal-Neural Axis. Gastroenterol. Insights 2009, 1, e3.

AMA Style

McLean PG, Calver AR, Alpers DH, Collins SM, Shanahan F, Lee K. The Emerging Role of the Microbial-Gastrointestinal-Neural Axis. Gastroenterology Insights. 2009; 1(1):e3.

Chicago/Turabian Style

McLean, Peter G., Andrew R. Calver, David H. Alpers, Stephen M. Collins, Fergus Shanahan, and Kevin Lee. 2009. "The Emerging Role of the Microbial-Gastrointestinal-Neural Axis" Gastroenterology Insights 1, no. 1: e3.

Article Metrics

Back to TopTop