Human Heart-Type Fatty Acid-Binding Protein as an Early Diagnostic Marker of Doxorubicin Cardiac Toxicity
Hematology Unit, Internal Medicine Department, Alexandria University, Alexandria 21544, Egypt
Cardiology Department, Faculty of Medicine, Alexandria University, Alexandria 21544, Egypt
Military Medical Academy, Alexandria 21544, Egypt
Author to whom correspondence should be addressed.
Hematol. Rev. 2009, 1(1), e6; https://doi.org/10.4081/hr.2009.e6 (registering DOI)
Original submission received: 13 January 2009
Revised: 9 April 2009
Accepted: 17 April 2009
Published: 28 April 2009
Progressive cardiotoxicity following treatment with doxorubicin-based chemotherapy in patients with non-Hodgkin’s lymphoma (NHL) may lead to late onset cardiomyopathy. So, early prediction of toxicity can lead to prevention of heart failure in these patients. The aim of this work was to investigate the role of H-FABP as an early diagnostic marker of anthracycline-induced cardiac toxicity together with brain natriuretic peptide (BNP) as an indication of ventricular dysfunction in such patients. Our study was conducted on 40 NHL patients who received 6 cycles of a doxorubicin containing chemotherapy protocol (CHOP), not exceeding the total allowed dose of doxorubicin (500 mg/m2). Ten healthy controls were included in our study. Human heart-type fatty acid-binding protein (H-FABP) was assessed 24 h after the first cycle of CHOP. Plasma levels of BNP were estimated both before starting chemotherapy and after the last cycle of CHOP. Resting echocardiography was also performed before and at the end of chemotherapy cycles. The ejection fraction (EF) of 8 of our patients decreased below 50% at the end of the sixth cycle. Elevated levels of both H-FABP and BNP were found in all patients wth EF below 50% and both markers showed a positive correlation with each other. We concluded that H-FABP may serve as a reliable early marker for prediction of cardiomyopathy induced by doxorubicin. Thus, in patients with elevated H-FABP, alternative treatment modalities with no cardiac toxicity may be considered in order to prevent subsequent heart failure in these patients.
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ElGhandour, A.H.; El Sorady, M.; Azab, S.; ElRahman, M.
Human Heart-Type Fatty Acid-Binding Protein as an Early Diagnostic Marker of Doxorubicin Cardiac Toxicity. Hematol. Rev. 2009, 1, e6.
ElGhandour AH, El Sorady M, Azab S, ElRahman M.
Human Heart-Type Fatty Acid-Binding Protein as an Early Diagnostic Marker of Doxorubicin Cardiac Toxicity. Hematology Reviews. 2009; 1(1):e6.
ElGhandour, Ashraf H., Manal El Sorady, Sahar Azab, and Mohammed ElRahman.
2009. "Human Heart-Type Fatty Acid-Binding Protein as an Early Diagnostic Marker of Doxorubicin Cardiac Toxicity" Hematology Reviews 1, no. 1: e6.
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