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Mar. Drugs, Volume 2, Issue 2 (June 2004) – 3 articles , Pages 55-82

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Review
Drugs and Cosmetics from the Sea
Mar. Drugs 2004, 2(2), 73-82; https://doi.org/10.3390/md202073 - 25 May 2004
Cited by 208 | Viewed by 26520
Abstract
The marine environment is a rich source of both biological and chemical diversity. This diversity has been the source of unique chemical compounds with the potential for industrial development as pharmaceuticals, cosmetics, nutritional supplements, molecular probes, fine chemicals and agrochemicals. In recent years, [...] Read more.
The marine environment is a rich source of both biological and chemical diversity. This diversity has been the source of unique chemical compounds with the potential for industrial development as pharmaceuticals, cosmetics, nutritional supplements, molecular probes, fine chemicals and agrochemicals. In recent years, a significant number of novel metabolites with potent pharmacological properties has been discovered from the marine organisms. Although there are only a few marine-derived products currently on the market, several robust new compounds derived from marine natural products are now in the clinical pipeline, with more clinical development. While the marine world offers an extremely rich resource for novel compounds, it also represents a great challenge that requires inputs from various scientific areas to bring the marine chemical diversity up to its therapeutic potential. Full article
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Article
Fucoxanthin and Its Metabolites in Edible Brown Algae Cultivated in Deep Seawater
Mar. Drugs 2004, 2(2), 63-72; https://doi.org/10.3390/md202063 - 25 May 2004
Cited by 120 | Viewed by 12474
Abstract
Three metabolites of fucoxanthin were isolated from a brown alga, Scytosiphon lomentaria, and the structure of a new compound was determined by NMR. The content of fucoxanthin, a biologically active carotenoid, in four edible brown algae, cultivated in deep seawater, was studied. Full article
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Article
Identification of Renieramycin A as an Antileishmanial Substance in a Marine Sponge Neopetrosia sp.
Mar. Drugs 2004, 2(2), 55-62; https://doi.org/10.3390/md202055 - 25 May 2004
Cited by 48 | Viewed by 9974
Abstract
The newly developed assay system using recombinant Leishmania amazonensis expressing enhanced green fluorescent protein (La/egfp) has been applied to the screening of Japanese marine sponges for antileishmanial activity. Bioassay-guided fractionation of an active sponge Neopetrosia sp. afforded an active compound which [...] Read more.
The newly developed assay system using recombinant Leishmania amazonensis expressing enhanced green fluorescent protein (La/egfp) has been applied to the screening of Japanese marine sponges for antileishmanial activity. Bioassay-guided fractionation of an active sponge Neopetrosia sp. afforded an active compound which was identified as renieramycin A by spectroscopic analysis. It inhibited La/egfp with an IC50 value of 0.2 μg/mL. Full article
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